Development Of The Lateral Equilibrium Reaction In Stance

Perham, Heidi; Smick, Janet E.; Hallum, Ann; Nordstrom, T. V.

doi:10.1111/j.1469-8749.1987.tb08821.x

Cited by 5 publications

(2 citation statements)

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“…These findings provide supportive evidence for prior work revealing an ability of glial cells in the head of the worm to communicate broadly to the rest of the worm body (Figure 9). The molecules that communicate these effects are suppression of oxidative stress (Perham et al, 1987;Philips & Rothstein, 2017). Local mechanisms allow for glial-neuron interdependence that may be determined by "who partners with who.…”

Section: Elegans Swip-10 Encodes a Novel Metallo β -Lactamase Domain-...mentioning

confidence: 99%

“…Possibly, such signals relay glial metabolic state or neuronal activation to the periphery, whereas the impact of glia on neighboring neurons is conveyed by different classes of molecules. Glia, both astrocytes and oligodendrocytes, are known to exchange many factors of diverse character (e.g., amino acids, lipids, metals) with neurons including molecules involved in energy production and suppression of oxidative stress (Perham et al, 1987; Philips & Rothstein, 2017). Local mechanisms allow for glial‐neuron interdependence that may be determined by “who partners with who.” The degenerative effects of swip‐10 mutation provide a demonstration of this, with neurons ensheathed by glia displaying neurodegeneration, whereas unsheathed neighbor neurons appear insensitive to the mutation (Murphy‐Royal et al, 2017).…”

Section: Glial Swip‐10: Support For Da Neuron Viabilitymentioning

confidence: 99%

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Sink or swim: Does a worm paralysis phenotype hold clues to neurodegenerative disease?

Rodriguez,

Blakely

2023

Journal Cellular Physiology

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Receiving a neurodegenerative disease (NDD) diagnosis, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis, is devastating, particularly given the limited options for treatment. Advances in genetic technologies have allowed for efficient modeling of NDDs in animals and brought hope for new disease‐modifying medications. The complexity of the mammalian brain and the costs and time needed to identify and develop therapeutic leads limits progress. Modeling NDDs in invertebrates, such as the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, offers orders of magnitude increases in speed of genetic analysis and manipulation, and can be pursued at substantially reduced cost, providing an important, platform complement and inform research with mammalian NDD models. In this review, we describe how our efforts to exploit C. elegans for the study of neural signaling and health led to the discovery of a paralytic phenotype (swimming‐induced paralysis) associated with altered dopamine signaling and, surprisingly, to the discovery of a novel gene and pathway whose dysfunction in glial cells triggers neurodegeneration. Research to date on swip‐10 and its putative mammalian ortholog MBLAC1, suggests that a tandem analysis will offer insights into NDD mechanisms and insights into novel, disease‐modifying therapeutics.

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Section: Elegans Swip-10 Encodes a Novel Metallo β -Lactamase Domain-...mentioning

confidence: 99%

Section: Glial Swip‐10: Support For Da Neuron Viabilitymentioning

confidence: 99%

Sink or swim: Does a worm paralysis phenotype hold clues to neurodegenerative disease?

Rodriguez,

Blakely

2023

Journal Cellular Physiology

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Interrater and Test-Retest Reliability of Two Pediatric Balance Tests

et al. 1990

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The purpose of this study was to examine the interrater and test-retest reliability of a one-leg balance test and a tiltboard balance test. Twenty-four normally developing children aged 4 through 9 years participated in the study. Time and quality of balance on one leg and degrees of tilt on a tiltboard prior to postural adjustment were measured. Both tests were completed with eyes open and with eyes closed. Interrater reliability was examined using two raters. Test-retest reliability, with a one-week interval between test and retest, was examined for a subgroup consisting of 12 children. Spearman rank-order correlation coefficients were used as indexes of both interrater and test-retest reliability for time and degrees of tilt. To supplement the correlation coefficients, the magnitudes of difference between raters' scores and between test and retest scores were calculated. Spearman coefficients were moderate to high for one-leg balance when scores for both feet were combined for both eyes-open and eyes-closed conditions. The magnitude of difference between scores was low, indicating good agreement between raters and across time. Interrater and test-retest reliabilities of quality of one-leg standing balance were examined by calculating percentages of agreement and Cohen's Kappa statistics. Results of these analyses revealed the need for further study. The Spearman coefficients for the interrater tiltboard test were high; however, the test-retest coefficients were low. The magnitudes of difference between scores were small for the two raters, but large for test and retest. These results are important to consider when using these tests for initial evaluation or for monitoring patient progress.

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Performance of Normal Children on the Pediatric Clinical Test of Sensory Interaction for Balance

Deitz¹,

Richardson²,

Atwater³

et al. 1991

The Occupational Therapy Journal of Research

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The purpose of this study was to collect and examine descriptive data on the Pediatric Clinical Test of Sensory Interaction for Balance (P-CTSIB) for children ages 6 to 9 years. To guide decisions regarding grouping of data, hypotheses were tested concerning differences among means for duration of stance for gender and for age. Because results were inconclusive, descriptive data for duration of stance and degrees of sway for each of the six P-CTSIB Feet-Together tests and each of the six P-CTSIB Heel-Toe tests are reported by gender and age category. Recommendations are made for clinical use of this test, and directions for future research are identified.

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Development Of The Lateral Equilibrium Reaction In Stance

Cited by 5 publications

References 5 publications

Sink or swim: Does a worm paralysis phenotype hold clues to neurodegenerative disease?

Sink or swim: Does a worm paralysis phenotype hold clues to neurodegenerative disease?

Interrater and Test-Retest Reliability of Two Pediatric Balance Tests

Performance of Normal Children on the Pediatric Clinical Test of Sensory Interaction for Balance

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