Development of sustained antimicrobial-release systems using poly(2-hydroxyethyl methacrylate)/trimethylolpropane trimethacrylate hydrogels

Kitagawa, Haruaki; Takeda, Kahoru; Kitagawa, Ranna; Izutani, Naomi; Miki, Saeki; Hirose, Nanako; Hayashi, Mikako; Imazato, Satoshi

doi:10.1016/j.actbio.2014.06.016

Cited by 28 publications

(21 citation statements)

References 50 publications

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“…In addition, previously reported polymer combinations such as HEMA and gelatin [22], hydroxyapatite [23], and polycaprolactone [24] are degradable. Kitagawa et al [9] developed a novel hydrogel consisting of polyme- 12 h and 1, 2, 3, 4, 5, 7, 10, and 14 days (n = 4).…”

Section: Discussionmentioning

confidence: 99%

“…In this binary resin system, TMPT forms the cross-linking structure, and the material is nondegradable and can be pulverized by milling. Because the ability of polyHEMA/TMPT to deliver the cationic antimicrobial cetylpyridinium chloride has already been demonstrated [9], this polymer was used in the present study as a promising non-biodegradable drug carrier for proteins. HEMA is a hydrophilic monomer [15,25], and polyHEMA shows high water absorbability [22,26].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, we developed a novel non-biodegradable hydrogel consisting of 2-hydroxyethyl methacrylate (HEMA) and the cross-linking monomer trimethylolpropane trimethacrylate (TMPT) and reported that these methacrylate-based hydrogels were provided the sustained release of cetylpyridinium chloride [9]. We hypothesized that this hydrogel could also be beneficial for tissue regeneration by releasing growth factors over time.…”

Section: Introductionmentioning

confidence: 97%

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Effectiveness of non-biodegradable poly(2-hydroxyethyl methacrylate)-based hydrogel particles as a fibroblast growth factor-2 releasing carrier

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Effectiveness of non-biodegradable poly(2-hydroxyethyl methacrylate)-based hydrogel particles as a fibroblast growth factor-2 releasing carrier

et al. 2015

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“…As a non-biodegradable carrier suitable for delivery of proteins or antimicrobials 29,30) , we have developed poly(2-hydroxyethylmethacrylate)/trimethylolpropane trimethacrylate (polyHEMA/TMPT) particles. When FGF-2 was loaded into such particles, a sustained release of FGF-2 was maintained for up to 14 days 28) .…”

Section: Discussionmentioning

confidence: 99%

Influence of polymerization properties of 4-META/MMA-based resin on the activity of fibroblast growth factor-2

et al. 2017

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Dental adhesive resins based on 4-methacryloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA) have been utilized for root-end filling and the bonding of fractured roots. To increase the success rate of these treatments, it would be beneficial to promote the healing of surrounding tissue by applying growth factors. In this study, the influences of the polymerization properties of 4-META/MMA-based resins on the activity of fibroblast growth factor-2 (FGF-2) were evaluated in vitro. The temperature increase caused by the heat generation during polymerization of the 4-META/MMA-based resin was insufficient to change the structure and function of FGF-2. Unpolymerized monomers released from the cured 4-META/MMA-based resin had no negative influences on the ability of FGF-2 to promote the proliferation of osteoblast-like cells. These findings suggest that it is possible to use FGF-2 in combination with 4-META/MMA-based resins.

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“…1), we newly developed non-biodegradable particles for the delivery of water-soluble agents 20,21) . These particles are made using methacrylate polymers and are compatible with any type of resin used for restorative treatments.…”

Section: Introductionmentioning

confidence: 99%

Non-biodegradable polymer particles for drug delivery: A new technology for “bio-active” restorative materials

et al. 2017

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To develop dental restorative materials with "bio-active" functions, addition of the capability to release active agents is an effective approach. However, such functionality needs to be attained without compromising the basic properties of the restorative materials. We have developed novel non-biodegradable polymer particles for drug delivery, aimed for application in dental resins. The particles are made using 2-hydroxyethyl methacrylate (HEMA) and a cross-linking monomer trimethylolpropane trimethacrylate (TMPT), with a hydrophilic nature to adsorb proteins or water-soluble antimicrobials. The polyHEMA/TMPT particles work as a reservoir to release fibroblast growth factor-2 (FGF-2) or cetylpyridinium chloride (CPC) in an effective manner. Application of the polyHEMA/ TMPT particles loaded with FGF-2 to adhesives, or those loaded with CPC to resin-based endodontic sealers or denture bases/crowns is a promising approach to increase the success of the treatments by conferring "bio-active" properties to these materials to induce tissue regeneration or to inhibit bacterial infection.

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Development of sustained antimicrobial-release systems using poly(2-hydroxyethyl methacrylate)/trimethylolpropane trimethacrylate hydrogels

Cited by 28 publications

References 50 publications

Effectiveness of non-biodegradable poly(2-hydroxyethyl methacrylate)-based hydrogel particles as a fibroblast growth factor-2 releasing carrier

Effectiveness of non-biodegradable poly(2-hydroxyethyl methacrylate)-based hydrogel particles as a fibroblast growth factor-2 releasing carrier

Influence of polymerization properties of 4-META/MMA-based resin on the activity of fibroblast growth factor-2

Non-biodegradable polymer particles for drug delivery: A new technology for “bio-active” restorative materials

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