Development of solid-state nanopore fabrication technologies

Deng, Tao; Li, Mengwei; Wang, Yifan; Liu, Zewen

doi:10.1007/s11434-014-0705-8

Cited by 70 publications

(44 citation statements)

References 148 publications

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“…This pore size is achievable with MoS2 monolayers but difficult to realize with SiNx membranes. [53,86,87] However, the noise level for solid-state nanopores is seldom smaller than 1 pA, [61,64,65,88] which is also seen in figure 4(b). Even we consider a more ideal case by referring to figure 3(a), ΔImin=1 pA is found for the same nanopore of dp=5 nm and h=5 nm.…”

Section: Way Forwardmentioning

confidence: 70%

On nanopore DNA sequencing by signal and noise analysis of ionic current

et al. 2016

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Scheicher, R. et al. (2016) On nanopore DNA sequencing by signal and noise analysis of ionic current. Our focus is placed on signal-boosting and noise-suppressing strategies in order to attain the single-nucleotide resolution. Apart from decreasing pore diameter and thickness, it is crucial to also reduce the translocation speed and facilitate a stepwise translocation. Our best-case scenario analysis points to severe challenges with employing plain nanopore technology, i.e., without recourse to any signal amplification strategy, in achieving sequencing with the desired single-nucleotide resolution. A conceptual approach based on strand synthesis in the nanopore of the translocating DNA from single-stranded to double-stranded is shown to yield a 10-fold signal amplification. Although it involves no advanced physics and is very simple in mathematics, this simple model captures the essence of nanopore sequencing and is useful in guiding the design and operation of nanopore sequencing. Nanotechnology

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Section: Way Forwardmentioning

confidence: 70%

On nanopore DNA sequencing by signal and noise analysis of ionic current

et al. 2016

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“…In this review we focus mainly on strategies for fabricating solid‐state single nanopores or nanochannels, we thus omit a comprehensive description of procedures that allow the production of multipore materials, such as sol–gel techniques or the production of anodized aluminum oxide. Synthetic methods for solid‐state single pore fabrication have been reviewed extensively and many of them will not be described in detailed here . Among the different techniques available for the fabrication of single nanopores, ion beam and electron beam techniques are by far the most commonly used ones.…”

Section: Fabrication Techniquesmentioning

confidence: 99%

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

et al. 2019

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Solid‐state nanopores are fascinating objects that enable the development of specific and efficient chemical and biological sensors, as well as the investigation of the physicochemical principles ruling the behavior of biological channels. The great variety of biological nanopores that nature provides regulates not only the most critical processes in the human body, including neuronal communication and sensory perception, but also the most important bioenergetic process on earth: photosynthesis. This makes them an exhaustless source of inspiration toward the development of more efficient, selective, and sophisticated nanopore‐based nanofluidic devices. The key point responsible for the vibrant and exciting advance of solid nanopore research in the last decade has been the simultaneous combination of advanced fabrication nanotechnologies to tailor the size, geometry, and application of novel and creative approaches to confer the nanopore surface specific functionalities and responsiveness. Here, the state of the art is described in the following critical areas: i) theory, ii) nanofabrication techniques, iii) (bio)chemical functionalization, iv) construction of nanofluidic actuators, v) nanopore (bio)sensors, and vi) commercial aspects. The plethora of potential applications once envisioned for solid‐state nanochannels is progressively and quickly materializing into new technologies that hold promise to revolutionize the everyday life.

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“…This particular interest in peptide detection is amplified by their potential involvement in the onset of cancer, neurodegenerative disorders, and infections 17–19 , as well as established correlations between their expression levels and diseases 20–22 . While synthetic nanopores are considered scalable and more robust both chemically and mechanically, their production with desired dimensions and sub-nanometer precision is still a challenging task 23–25 . In contrast, nanopores of biological origin present outstanding structural repeatability at the atomic level and are more amenable to chemical modification and sophisticated bio-engineering procedures intended to significantly extend their sensing capabilities 6, 26–28 .…”

Section: Introductionmentioning

confidence: 99%

Stochastic sensing of Angiotensin II with lysenin channels

Shrestha

Bryant

Thomas

et al. 2017

Sci Rep

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The ability of pore-forming proteins to interact with various analytes has found vast applicability in single molecule sensing and characterization. In spite of their abundance in organisms from all kingdoms of life, only a few pore-forming proteins have been successfully reconstituted in artificial membrane systems for sensing purposes. Lysenin, a pore-forming toxin extracted from the earthworm E. fetida, inserts large conductance nanopores in lipid membranes containing sphingomyelin. Here we show that single lysenin channels may function as stochastic nanosensors by allowing the short cationic peptide angiotensin II to be electrophoretically driven through the conducting pathway. Long-term translocation experiments performed using large populations of lysenin channels allowed unequivocal identification of the unmodified analyte by Liquid Chromatography-Mass Spectrometry. However, application of reverse voltages or irreversible blockage of the macroscopic conductance of lysenin channels by chitosan addition prevented analyte translocation. This investigation demonstrates that lysenin channels have the potential to function as nano-sensing devices capable of single peptide molecule identification and characterization, which may be further extended to other macromolecular analytes.

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Development of solid-state nanopore fabrication technologies

Cited by 70 publications

References 148 publications

On nanopore DNA sequencing by signal and noise analysis of ionic current

On nanopore DNA sequencing by signal and noise analysis of ionic current

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

Stochastic sensing of Angiotensin II with lysenin channels

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