“…It should be noted that the operating pH ranges given in [24,25] do not agree with the data on the solubility of the molecular form of terbinafine in water, which is 5.22 μM [27]. The pKa values of terbinafine given in the literature are characterized by a large scatter (from 7.05 to 8.94) [27][28][29], however, even with the maximum of the given values, the solubility of terbinafine at pH = 9 should not exceed 5×10 À 6 M. Further, according to [15] and [29], the potential of terbinafine-SE remains constant in the pH ranges 3-6 and 1-3, respectively, after which a sharp decrease in the potential occurs. The data presented in [29] are consistent with those obtained by us and seem to be the most reliable, although the given explanation of the drop in potential due to a decrease in the solubility of terbinafine at pH > 3, is not consistent with the rather high basicity of terbinafine.…”