Development of PCL/PEO electrospun fibrous membranes blended with silane-modified halloysite nanotube as a curcumin release system

Bulbul, Y. Emre; Okur, Müjgan; Korkmaz, Funda Demirtaş; Dilsiz, Nursel

doi:10.1016/j.clay.2019.105430

Cited by 47 publications

(14 citation statements)

References 102 publications

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“…Further evidence of the dehydrated state is the existence of the (110) basal reflection at 2θ = 19.80° and the (002) basal reflection at 2θ = 24.62°. 49 The drug's prominent peak (10.22°) was also observed in silver sulfadiazine-loaded halloysite (Figure 5(a)). However, it showed a reduction in some characteristic peaks' intensity and disappearance, indicating the drug-halloysite complexation and crystallinity reduction.…”

Section: Resultsmentioning

confidence: 85%

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

et al. 2021

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(Bio)nanocomposites have been studied for biomedical applications, including the treatment of wounds. However, wound infection is one of the main problems of wound care management, and the use of wound dressings with antibacterial agents is essential. This work focused on developing and characterizing silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites potentially suitable as antimicrobial dressing. Silver sulfadiazine was complexed inside the halloysite nanotubes lumen, and the drug-loaded nanotubes were incorporated in thermoplastic starch dispersion, forming the (bio)nanocomposites. The silver sulfadiazine-loaded halloysite and the (bio)nanocomposite were characterized by zeta potential, scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. The dressing properties of (bio)nanocomposites (water vapor permeability and mechanical stability) and their antimicrobial efficacy by Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were also evaluated. Physicochemical studies suggested the silver sulfadiazine-loaded halloysite complexation (zeta potential of −38.9 mV) and its interactions with the starch forming the nanocomposites. The silver sulfadiazine-loaded halloysite/starch-based (bio)nanocomposites possessed a homogeneous and organized structure. Also, they had mechanical properties to be used as a dressing (13.73 ± 3.09 MPa and 3.17 ± 1.28% of elongation at break), and its permeability (6.18 ± 0.43 (10−13) g.Pa−1.s−1.m−1) could be able to maintain the environmental moisture at the wound surface. Besides that, the (bio)nanocomposites acted against the studied bacteria, being a potential contact antimicrobial and biodegradable wound dressing. Finally, the developed (bio)nanocomposites are semi-occlusive and good candidates for dry wounds to be widely in vitro and in vivo tested as controlled silver sulfadiazine delivery dressing.

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Section: Resultsmentioning

confidence: 85%

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

et al. 2021

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“…151 For example, although PCL is extensively applied in biomedical and pharmaceutical fields, its hydrophobic features lower the ability of drug loading and releases ability. 152 Many researchers have reported HNT as a crucial technology for drug deliveries. 52,96,[151][152][153][154] Massaro et al stated that HNT could be used as a natural nanocarrier for loaded active substances and nanocomposites thanks to its large surface area, high dispersion, hollow tubular structure, large cavity volumes, and flexible surface structure.…”

Section: Drug Deliverymentioning

confidence: 99%

“…152 Many researchers have reported HNT as a crucial technology for drug deliveries. 52,96,[151][152][153][154] Massaro et al stated that HNT could be used as a natural nanocarrier for loaded active substances and nanocomposites thanks to its large surface area, high dispersion, hollow tubular structure, large cavity volumes, and flexible surface structure. Other attractive properties include non-toxic, hydrophilic, and low production costs.…”

Section: Drug Deliverymentioning

confidence: 99%

Recent advancement in polymer/halloysite nanotube nanocomposites for biomedical applications

et al. 2022

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Halloysite nanotubes (HNTs) have recently been the subject of extensive research as a reinforcing filler. HNT is a natural nanoclay, non‐toxic and biocompatible, hence, applicable in biomedical fields. This review focuses on the mechanical, thermal, and functional properties of polymer nanocomposites with HNT as a reinforcing agent from an experimental and theoretical perspective. In addition, this review also highlights the recent applications of polymer/HNT nanocomposites in the biomedical fields.

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“…Bulbul et al [ 49 ] proposed a curcumin delivery system based on the fibrous electrospun PCL/PEO/HNTs membranes loaded with curcumin. To optimize the drug loading HNTs were modified with 3-aminopropyltriethoxysilane (APTES) or 3-glycidoxypropyltrimethoxysilane (GPTMS) prior to incorporating them into the membranes.…”

Section: Hnts In Controlled Delivery Of Anticancer Drugsmentioning

confidence: 99%

Application of Halloysite Nanotubes in Cancer Therapy—A Review

Karewicz

Machowska

et al. 2021

Materials

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Halloysite, a nanoclay characterized by a unique, tubular structure, with oppositely charged interior and exterior, suitable, nanometric-range size, high biocompatibility, and low cost, is recently gaining more and more interest as an important and versatile component of various biomaterials and delivery systems of biomedical relevance. One of the most recent, significant, and intensely studied fields in which halloysite nanotubes (HNTs) found diverse applications is cancer therapy. Even though this particular direction is mentioned in several more general reviews, it has never so far been discussed in detail. In our review, we offer an extended survey of the literature on that particular aspect of the biomedical application of HNTs. While historical perspective is also given, our paper is focused on the most recent developments in this field, including controlled delivery and release of anticancer agents and nucleic acids by HNT-based systems, targeting cancer cells using HNT as a carrier, and the capture and analysis of circulating tumor cells (CTCs) with nanostructured or magnetic HNT surfaces. The overview of the most up-to-date knowledge on the HNT interactions with cancer cells is also given.

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Development of PCL/PEO electrospun fibrous membranes blended with silane-modified halloysite nanotube as a curcumin release system

Cited by 47 publications

References 102 publications

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

Recent advancement in polymer/halloysite nanotube nanocomposites for biomedical applications

Application of Halloysite Nanotubes in Cancer Therapy—A Review

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