Development of nanoparticles for pharmaceutical preparations using supercritical techniques

Islam, Tariqul; Ragib, Abdullah Al; Ferdosh, Sahena; Uddin, A. B. M. Helal; Jahurul, M.H.A.; Mia, Md. Abdur Rashid; M, Reddy Prasad D.; Kamaruzzaman, B. Y.; Sarker, Md. Zaidul Islam

doi:10.1080/00986445.2021.1983545

Cited by 11 publications

(5 citation statements)

References 169 publications

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“…Other techniques include continuous powder coating and spraying process (CPCSP), gas-assisted melting atomization (GAMA), precipitation by pressure reduction of gas-expanded liquids (PPRGEL), CO2-assisted nebulization with a bubble dryer (CAN-BD), supercritical-assisted injection in a liquid antisolvent (SAILA), supercritical-assisted atomization (SAA), supercritical-assisted spray-drying (SASD), supercritical-assisted atomization using hydrodynamic cavitation mixer (SAA-HCM), supercritical-enhanced atomization (SEA), depressurization of an expanded-liquid organic solution (DELOS), and particle formation from gas-saturated solutions with drying (CSS) or concentrated powder form (CPF). The mentioned techniques are described elsewhere (1,50,51).…”

Section: Methods For Micro and Nano-particles Productionmentioning

confidence: 99%

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Milovanović¹,

Lukić²

2022

Arhiv za farmaciju

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Supercritical carbon dioxide (scCO2) application in the pharmaceutical industry is still undeveloped regardless of significant research interests in this processing medium shown in the last decades. ScCO2 technologies can improve drug solubility, bioavailability, and therapeutic effect. These technologies can lead to the development of new formulations that will contribute to a decrease in drug dose, medication frequency, and increase patients' well-being. Considering the significant decrease in the price of high-pressure equipment and society's growing need for cleaner production and safer products, it is expected that symbiosis between supercritical fluid and pharmaceutical technologies will happen soon. Therefore, this review was focused on the latest contributions of scCO2 technologies to the pharmaceutical field. The main aim was to bring these technologies closer to pharmaceutical specialists. For this purpose, the most commonly used technologies were explained and discussed: the preparation of solid dispersions, polymer impregnation with drugs, and drug micro/nanoparticle production using scCO2.

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Section: Methods For Micro and Nano-particles Productionmentioning

confidence: 99%

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Milovanović¹,

Lukić²

2022

Arhiv za farmaciju

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“…Another approach to enhancing the therapeutic effectiveness of poorly soluble drugs by reducing their particle size involves the supercritical CO 2 -assisted technique (Figure 3) [41][42][43][44][45][46]. A substance reaches a supercritical fluid state when its temperature and pressure surpass the critical point.…”

Section: Supercritical Technologiesmentioning

confidence: 99%

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Shabatina,

Gromova,

Vernaya

et al. 2024

Pharmaceuticals

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The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness of pharmaceutical preparations to be increased due to several factors: (1) the high specific surface area of nanomaterials, and (2) the high concentration of surface-active centers interacting with biological objects. In the case of drug nanoforms, even low concentrations of a bioactive substance can have a significant therapeutic effect on living organisms. These effects allow pharmacists to use lower doses of active components, consequently lowering the toxic side effects of pharmaceutical nanoform preparations. It is known that many drug substances that are currently in development are poorly soluble in water, so they have insufficient bioavailability. Converting them into nanoforms will increase their rate of dissolution, and the increased saturation solubility of drug nanocrystals also makes a significant contribution to their high therapeutic efficiency. Some physical and chemical methods can contribute to the formation of both pure drug nanoparticles and their ligand or of polymer-covered nanoforms, which are characterized by higher stability. This review describes the most commonly used methods for the preparation of nanoforms (nanoparticles) of different medicinal substances, paying close attention to modern supercritical and cryogenic technologies and the advantages and disadvantages of the described methods and techniques; moreover, the improvements in the physico-chemical and biomedical properties of the obtained medicinal nanoforms are also discussed.

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“…Tab. 10 shows the schematic of the RESS, GAS, SAS, ASES, SFEE, SEDS, and PGSS processes [83,[425][426][427]. Each method is used according to the drug conditions and process conditions.…”

Section: Role(s) Of Sc-co 2 Authors Referencesmentioning

confidence: 99%

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Sodeifian

Usefi

2022

ChemBioEng Reviews

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Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4 MPa and 31.1 °C. Given the request for consumption of a green solvent for the environment, SC‐CO2 is widely utilized in chemical, food, and pharmaceutical industries. To design material and drug production processes using supercritical fluid (SCF) technology, knowledge of their solubility is important. Temperature and pressure are the main factors in the study of solubility. Solubility data are then evaluated using equation of state, semi‐empirical, and intelligence models to establish suitable correlations. SC‐CO2 is one of the most important materials used in SCFs to study solubility. Another application of SC‐CO2 is in the field of material extraction to reduce the consumption of organic solvents. Nanoparticles production in drug industry is another advantage of SC‐CO2. Micro and nanoparticles can be produced using SCF techniques. In this review, the applications of SC‐CO2 in drug solubility, extraction of valuable materials, and nanoparticles production for pharmaceutical processes are reported and discussed. Finally, the main challenges are explained.

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Development of nanoparticles for pharmaceutical preparations using supercritical techniques

Cited by 11 publications

References 169 publications

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

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