Development of LC–MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl.

Novotný, Ladislav; Abdel‐Hamid, Mohammed E.; Hamza, Hoda; Maśterová, I; Grančai, D

doi:10.1016/s0731-7085(02)00706-9

Cited by 44 publications

(25 citation statements)

References 8 publications

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“…159 Another rapid liquid chromatography-mass spectrometry (LC-MS) method for the determination of ursolic acid in rat plasma was developed and validated. 160 See supplementary material 5.9.…”

Section: 9development Of Liquid Chromatography-mass Spectrometry Mmentioning

confidence: 99%

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Sultana

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Medicinal plants are becoming an important research area for novel and bioactive molecules for drug discovery. Novel therapeutic strategies and agents are urgently needed to treat different incurable diseases. Many plant derived active compounds are in human clinical trials. Currently ursolic acid is in human clinical trial for treating cancer, tumor, and skin wrinkles. This review includes the clinical use of ursolic acid in various diseases including anticancer, antitumor, and antiwrinkle chemotherapies, and the isolation and purification of this tritepernoid from various plants to update current knowledge on the rapid analysis of ursolic acid by using analytical methods. In addition, the chemical modifications of ursolic acid to make more effective and water soluble derivatives, previous and current information regarding, its natural and semisynthetic analogs, focusing on its anticancer, cytotoxic, antitumor, antioxidant, antiinflammatory, anti-HIV, acetyl cholinesterase, α-glucosidase, antimicrobial, and hepatoprotective activities, briefly discussion is attempted here for its research perspectives. This review article contains fourteen medicinally important ursolic acid derivatives and 351 references.

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Section: 9development Of Liquid Chromatography-mass Spectrometry Mmentioning

confidence: 99%

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Sultana

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Two LC/MS methods for ursolic acid quantitation in plants with liquid-liquid extraction (LLE) [6], and supercritical fluid extraction (SFE) [7] have been reported. However, both methods required complicated pretreatment of samples and high consumption of chemical agents with low sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study

Xia

Wei

et al. 2011

Journal of Chromatography B

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“…Capillary supercritical fluid chromatography [15], LC-MS method [16] and GC-MS after derivatisation have also been used for plant analysis [17,18]. TLC method for qualitative determination of pentacyclic triterpenes was also described [19,20].…”

Section: Introductionmentioning

confidence: 99%

HPTLC‐densitometric method of determination of oleanolic acid in the Lamii albi flos

Wójciak–Kosior

Krzaczek

Matysik

et al. 2005

J of Separation Science

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HPTLC combined with densitometric method was used to determine the content of oleanolic acid in acetone extract from the Lamii albi flos L. The plant extract was separated on Si 60 HPTLC plates and determined with the use of two densitometric methods: measurement of fluorescence and absorbance. The content of oleanolic acid was statistically calculated. In a measurement of absorbance in 1 g of the dry Lamii albi flos L. 1458 microg of oleanolic acid was determined (0.147%). In a fluorescence method in 1 g of the plant material 1516 microg of oleanolic acid was determined (0.149%).

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Development of LC–MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl.

Cited by 44 publications

References 8 publications

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study

HPTLC‐densitometric method of determination of oleanolic acid in the Lamii albi flos

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