Development of injectable biocomposites from hyaluronic acid and bioactive glass nano-particles obtained from different sol–gel routes

Sohrabi, Mehri; Hesaraki, Saeed; Kazemzadeh, Asghar; Alizadeh, Mohammad

doi:10.1016/j.msec.2013.05.005

Cited by 44 publications

(42 citation statements)

References 52 publications

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“…BG powder based on 64SiO 2 ‐31CaO‐5P 2 O 5 system was synthesized using water‐based sol‐gel process as described previously . Briefly, (0.64 mol) of tetraethyl orthosilicate (TEOS, C 8 H 20 SiO 4 ) was poured into 300 mL 0.1 M nitric acid (HNO 3 ) solution and stirred for 1 h at room temperature for acid hydrolysis.…”

Section: Methodsmentioning

confidence: 99%

“…The rheological properties of the nanocomposite pastes in both rotatory and oscillatory modes were conducted as described elsewhere . MC‐R301 Rheometer with plate‐plate measuring geometry (plate diameter of 25 mm) was employed for these purposes.…”

Section: Methodsmentioning

confidence: 99%

“…Using high molecular weight HAc and sodium alginate could improve cohesion properties of CP pastes . In our previous study, composites of HAc solution and nano‐BG particles with different physical characteristics were designed and evaluated in simulated body fluid (SBF) solution under static situation …”

Section: Introductionmentioning

confidence: 99%

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The influence of polymeric component of bioactive glass‐based nanocomposite paste on its rheological behaviors and in vitro responses: Hyaluronic acid versus sodium alginate

2013

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Different biocomposite pastes were prepared from a solid phase that was nanoparticles of sol-gel-derived bioactive glass and different liquid phases including 3% hyaluronic acid solution, sodium alginate solutions (3% and 10 %) or mixtures of hyaluronic acid and sodium alginate (3% or 10 %) solutions in 50:50 volume ratio. Rheological properties of the pastes were measured in both rotatory and oscillatory modes. The washout behavior and in vitro apatite formation of the pastes were determined by soaking them in simulated body fluid under dynamic situation for 14 days. The proliferation and alkaline phosphatase activity of MG-63 osteoblastic cells were also determined using extracts of the pastes. All pastes could be easily injected from the standard syringes with different tip diameters. All pastes exhibited visco-elastic character, but a nonthixotropic paste was obtained using hyaluronic acid in which the loss modulus was higher than the storage modulus. The thixotropy and storage modulus were increasingly improved by adding/using sodium alginate as mixing liquid. Moreover, the pastes in which the liquid phase was sodium alginate or mixture of hyaluronic acid and 10% sodium alginate solution revealed better apatite formation ability and washout resistance than that made of hyaluronic acid alone. No cytotoxicity effects were observed by extracts of the pastes on osteoblasts but better alkaline phosphatase activity was found for the pastes containing hyaluronic acid. Overall, injectable biocomposites can be produced by mixing bioactive glass nanoparticles and sodium alginate/hyaluronic acid polymers. They are potentially useful for hard and even soft tissues treatments.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The influence of polymeric component of bioactive glass‐based nanocomposite paste on its rheological behaviors and in vitro responses: Hyaluronic acid versus sodium alginate

2013

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“…It has excellent biocompatibility and viscoelastic properties. Injectable nanocomposite of it prepared with nBG shows good injectability [88]. However, aggregation of BG and little disintegration of the paste in simulated body fluid are observed which are not desired.…”

Section: Other Polymer Compositesmentioning

confidence: 99%

Design of biocomposite materials for bone tissue regeneration

Basha

Kumar

Doble

2015

Materials Science and Engineering: C

243

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“…The influence of the BG particle size on the dynamic rheological changes over time (viscosity, storage and loss moduli) was recently investigated [6][7][8]. The main efforts aimed at tailoring the compositions and the textural properties of BG-organic carriers in order to improve the biomineralisation kinetics, i.e., the deposition of a surface apatite layer [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Tailoring the viscoelastic properties of injectable biocomposites: A spectroscopic assessment of the interactions between organic carriers and bioactive glass particles

et al. 2016

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Injectable bioglass (BG) pastes were produced using a melt-quenched glass based on CaO-MgO-SiO 2 -Na 2 O-P 2 O 5 -CaF 2 and two organic carriers, namely polyethylene glycol (PEG) and glycerol (Gly). The interactions between the organic carriers and the surface of the BG particles were assessed by spectroscopic methods (Fourier Transform Infrared, Raman, as well as 29Si and 13C solid-state NMR spectroscopy) in order to understand their effects on the viscoelastic properties of the biocomposites. While pure physical interactions were detected between PEG and the surface of the BG particles, chemical bonding was observed between glycerol and BG, enhancing the network cross-linking degree. Accordingly, the BG network of Gly-BG pastes was more condensed (higher fraction of Q [3] units detected by Raman spectroscopy) in comparison to that of PEG-BG and bare BG. Such chemical interactions between the organic carrier and BG were shown to negatively affect the viscoelastic behaviour of the resulting pastes. Thus, the PEG-based biocomposite exhibited improved flowability in comparison to its analogous Gly-BG biocomposite.

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Development of injectable biocomposites from hyaluronic acid and bioactive glass nano-particles obtained from different sol–gel routes

Cited by 44 publications

References 52 publications

The influence of polymeric component of bioactive glass‐based nanocomposite paste on its rheological behaviors and in vitro responses: Hyaluronic acid versus sodium alginate

The influence of polymeric component of bioactive glass‐based nanocomposite paste on its rheological behaviors and in vitro responses: Hyaluronic acid versus sodium alginate

Design of biocomposite materials for bone tissue regeneration

Tailoring the viscoelastic properties of injectable biocomposites: A spectroscopic assessment of the interactions between organic carriers and bioactive glass particles

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