The influence of polymeric component of bioactive glass‐based nanocomposite paste on its rheological behaviors and <i>in vitro</i> responses: Hyaluronic acid <i>versus</i> sodium alginate

Sohrabi, Mehri; Hesaraki, Saeed; Kazemzadeh, Asghar

doi:10.1002/jbm.b.33035

Cited by 25 publications

(26 citation statements)

References 50 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently the contact area and interaction between glass particles and the gum will be higher, which in turn results in the higher viscosity of the paste. To formulate a paste with suitable fluidity and injectability, the particle size of the glass should be maintained at an optimal level . With regards to the formation of the pastes with appropriate rheological properties, it appears that the glass particles are of the optimal size.…”

Section: Resultsmentioning

confidence: 99%

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Rasti

Hesaraki

Nezafati

2019

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Injectable composite pastes were prepared using melt‐derived 45S5 bioactive glass and tragacanth crosslinked by (3‐glycidyloxypropyl)trimethoxysilane (GPTMS). The effect of powder to liquid ratio (P:L = 1.0:2.0–1.0:2.5) and GPTMS/tragacanth ratio (0.0–1.5) on the injectability, swelling behavior, rheology, bioactivity, and cellular behavior of the pastes was investigated. Based on the results, the apparent stability and consistency of the pastes increased upon crosslinking by GPTMS. Due to the increased interactions between tragacanth and glass, a hysteresis loop with larger area was formed in the presence of GPTMS. With increase of GPTMS:tragacanth ratio from 0 to 1.5, the swelling percent dropped from 24.65 to 16.25% after 24 h and the degradation percent also went down from 27.89 to 9.11% after 21 days in the simulated body fluid. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay showed a drop in the optical density of MG63 osteoblasts up to 30.07% after exposure to the GPTMS‐crosslinked composite pastes for 3 days. However, the number of viable cells gradually increased in the presence of the pastes and the cell morphology remained unchanged over time. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47604.

show abstract

Section: Resultsmentioning

confidence: 99%

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Rasti

Hesaraki

Nezafati

2019

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…The absorption bands at 1,630 and 3,000-3,750 cm −1 are assigned to OH. [36,63] The bands at approximately 560 and 603 cm −1 are also attributed to ν 4 -(PO 4 ) 3− of apatite. [38] In pure gelatin, NH bending and CN stretch are shown at 1,238 cm −1 for amide III.…”

mentioning

confidence: 95%

Rheology, injectability, and bioactivity of bioactive glass containing chitosan/gelatin, nano pastes

Sohrabi

Yekta

Rezaie

et al. 2020

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Bioactive pastes containing bioactive sol–gel derived glass (BG) and various amounts of chitosan (Cn) and gelatin (Gel) were prepared in this study. To be exact, three pastes were prepared by mixing 25 parts by weight of glass powder with (a) 100 parts by weight of a 3 wt% acetic acid‐based chitosan solution, (b) 100 parts by weight of a 3 wt% water‐based gelatin solution, and (c) 100 parts by weight of a solution containing equal amounts of the above‐mentioned solutions. The bioactivity of the composite samples was evaluated by the immersion of the prepared pastes into the simulated body fluid (SBF) solution. The samples were also analyzed by X‐ray diffractometry (XRD), Brunauer–Emmett–Teller (BET), scanning electron microscope (SEM), Fourier transform infrared (FTIR), and atomic absorption spectroscopy (AAS). The results indicated better apatite formation capacity on the glass‐/chitosan‐/gelatin‐injected paste after 14 days. Furthermore, unlike the chitosan containing paste, the gelatin‐containing sample was injectable and displayed viscoelastic behavior as determined by conducting the rheology test in oscillation mode. In addition, while chitosan made the paste more viscous, it improved the washout resistance when compared to the gelatin‐containing sample. The experimental results also indicate the formation of spherical calcites in the pastes prior to immersion into the SBF solution.

show abstract

“…This is a relatively new idea in the field, but has merit due to its ability for thermoregulation, particle size regulation, structural support, and bone compatibility/binding abilities. 68 The problem however is that in at least one study, the gelation points become very sensitive to increasing amounts of these compounds. 69 Thus, more research is needed on the subject.…”

Section: Biodegradable Delivery Systemsmentioning

confidence: 99%

“…Consequently, this resulted in decreased migration of necessary degradation products to the osteoblasts and diminished results. 91 …”

Section: Biodegradable Delivery Systemsmentioning

confidence: 99%

The use of nanomaterials to treat bone infections

Snoddy

Jayasuriya

2016

Materials Science and Engineering: C

View full text Add to dashboard Cite

A new era of osteomyelitis treatment has been taking strides towards efficient, local administration of antibiotics at the site of infection. By having them localized to the site of infection, this toxicity is no longer an issue and actually has shown to be a more productive treatment for osteomyelitis. Researchers have focused the production of non-biodegradable, antibiotic, infused bone cements specifically designed for proficient osteocyte binding, useful antibiotic release over a desirable period of time, and promotion of bone regeneration. These cements are then surgically placed on the infected site following debridement and irrigation. The problem, however, is that the use of ineffective cements and the overuse of antibiotics has led to the development of resistant bacteria. Due to this, further research is being done in the field of antibiotic discovery and delivery. Specifically, the development of biodegradable materials capable of efficiently delivering antibiotics and also eliminating the need for follow-up surgery to remove the delivery material is being done, thus reducing exposure risk. Nanoparticles have been developed in the forms of scaffolds and injections to deliver a higher degree and longer lasting duration of antibiotic release, while promoting bone regeneration.

show abstract

The influence of polymeric component of bioactive glass‐based nanocomposite paste on its rheological behaviors and in vitro responses: Hyaluronic acid versus sodium alginate

Cited by 25 publications

References 50 publications

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Rheology, injectability, and bioactivity of bioactive glass containing chitosan/gelatin, nano pastes

The use of nanomaterials to treat bone infections

Contact Info

Product

Resources

About