Design of biocomposite materials for bone tissue regeneration

Basha, Rubaiya Yunus; Kumar, T.S. Sampath; Doble, Mukesh

doi:10.1016/j.msec.2015.07.016

Cited by 243 publications

(93 citation statements)

References 111 publications

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“…Metallic devices such as plates/screws, rods and fixators are widely used, but despite their excellent mechanical properties, they are not bioactive or bioresorbable, thus limiting their performance and requiring additional surgical procedures in case of revision [25]. Moreover, due to stress shielding effects, they can cause bone resorption and consequent implant loosening [25]. Ceramics represent a valuable alternative due to their availability and adaptation to various applications.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Composite Hydrogels for Bone Regeneration

et al. 2016

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Over the past few decades, bone related disorders have constantly increased. Among all pathological conditions, osteoporosis is one of the most common and often leads to bone fractures. This is a massive burden and it affects an estimated 3 million people only in the UK. Furthermore, as the population ages, numbers are due to increase. In this context, novel biomaterials for bone fracture regeneration are constantly under development. Typically, these materials aim at favoring optimal bone integration in the scaffold, up to complete bone regeneration; this approach to regenerative medicine is also known as tissue engineering (TE). Hydrogels are among the most promising biomaterials in TE applications: they are very flexible materials that allow a number of different properties to be targeted for different applications, through appropriate chemical modifications. The present review will focus on the strategies that have been developed for formulating hydrogels with ideal properties for bone regeneration applications. In particular, aspects related to the improvement of hydrogels’ mechanical competence, controlled delivery of drugs and growth factors are treated in detail. It is hoped that this review can provide an exhaustive compendium of the main aspects in hydrogel related research and, therefore, stimulate future biomaterial development and applications.

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Section: Bone Tissue Engineeringmentioning

confidence: 99%

Composite Hydrogels for Bone Regeneration

et al. 2016

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“…For example, ceramic-polymer composites have long been investigated in order to marry the rsif.royalsocietypublishing.org J. R. Soc. Interface 14: 20170093 biological properties of calcium phosphate ceramics with the mechanical properties of polymers, and this has created some interesting materials [38]. However, such materials have not been able to fully address the clinical need.…”

Section: Nanocomposite Materialsmentioning

confidence: 99%

Enhancing regenerative approaches with nanoparticles

Rijt

Habibović

2017

J. R. Soc. Interface.

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In this review, we discuss recent developments in the field of nanoparticles and their use in tissue regeneration approaches. Owing to their unique chemical properties and flexibility in design, nanoparticles can be used as drug delivery systems, to create novel features within materials or as bioimaging agents, or indeed these properties can be combined to create smart multifunctional structures. This review aims to provide an overview of this research field where the focus will be on nanoparticle-based strategies to stimulate bone regeneration; however, the same principles can be applied for other tissue and organ regeneration strategies. In the first section, nanoparticlebased methods for the delivery of drugs, growth factors and genetic material to promote tissue regeneration are discussed. The second section deals with the addition of nanoparticles to materials to create nanocomposites. Such materials can improve several material properties, including mechanical stability, biocompatibility and biological activity. The third section will deal with the emergence of a relatively new field of research using nanoparticles in advanced cell imaging and stem cell tracking approaches. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.

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“…These grafted materials must ensure mechanical stability and provide the appropriate environment for efficient healing. 8,9 These approaches present several limitations: (1) autografts may involve tissue morbidity, and moreover, the availability of donor tissue is limited; (2) allografts cause an important risk of infection and immunogenic rejection mechanisms; and (3) solid biomaterials such as metal or ceramic implants do not easily fit the size and shape of the defect. 10 Although recent advances in three-dimensional (3D) printing of solid materials have enabled the fabrication of size and shape-controlled materials, their surgical implantation to fit the morphology of the damaged site is far from easy.…”

Section: Introductionmentioning

confidence: 99%

Cellularizing hydrogel-based scaffolds to repair bone tissue: How to create a physiologically relevant micro-environment?

et al. 2017

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Tissue engineering is a promising alternative to autografts or allografts for the regeneration of large bone defects. Cell-free biomaterials with different degrees of sophistication can be used for several therapeutic indications, to stimulate bone repair by the host tissue. However, when osteoprogenitors are not available in the damaged tissue, exogenous cells with an osteoblast differentiation potential must be provided. These cells should have the capacity to colonize the defect and to participate in the building of new bone tissue. To achieve this goal, cells must survive, remain in the defect site, eventually proliferate, and differentiate into mature osteoblasts. A critical issue for these engrafted cells is to be fed by oxygen and nutrients: the transient absence of a vascular network upon implantation is a major challenge for cells to survive in the site of implantation, and different strategies can be followed to promote cell survival under poor oxygen and nutrient supply and to promote rapid vascularization of the defect area. These strategies involve the use of scaffolds designed to create the appropriate micro-environment for cells to survive, proliferate, and differentiate in vitro and in vivo. Hydrogels are an eclectic class of materials that can be easily cellularized and provide effective, minimally invasive approaches to fill bone defects and favor bone tissue regeneration. Furthermore, by playing on their composition and processing, it is possible to obtain biocompatible systems with adequate chemical, biological, and mechanical properties. However, only a good combination of scaffold and cells, possibly with the aid of incorporated growth factors, can lead to successful results in bone regeneration. This review presents the strategies used to design cellularized hydrogel-based systems for bone regeneration, identifying the key parameters of the many different micro-environments created within hydrogels.

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Design of biocomposite materials for bone tissue regeneration

Cited by 243 publications

References 111 publications

Composite Hydrogels for Bone Regeneration

Composite Hydrogels for Bone Regeneration

Enhancing regenerative approaches with nanoparticles

Cellularizing hydrogel-based scaffolds to repair bone tissue: How to create a physiologically relevant micro-environment?

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