Development of Hematopoietic Cancers After Implantation of Total Joint Replacement

Gillespie, W. J.; Henry, David; O’Connell, Dianne; Kendrick, Samantha; Juszczak, Ed; McInneny, Kevin; Derby, Laura E.

doi:10.1097/00003086-199608001-00026

Cited by 86 publications

(39 citation statements)

References 6 publications

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“…Concern about potential metal ion carcinogenicity has been expressed by such authors as Gillespie et al [16], Haynes et al [20], Hicks et al [21], Howie et al [22], and Lintner et al [30]. Metal wear debris also causes inflammatory, toxic, or allergic local tissue reactions [I, 10,11,18,29,47,49], which may lead to implant loosening [23,26,28,34,41].…”

Section: Discussionmentioning

confidence: 99%

Four‐year study of cobalt and chromium blood levels in patients managed with two different metal‐on‐metal total hip replacements

Lhotka

Szekeres

Steffan

et al. 2003

Journal Orthopaedic Research

216

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Buckground: Metal-on-metal total hip prostheses will produce a certain amount of wear debris. This results in increased wholeblood metal levels, which may cause adverse effects. It is not known to what extent the problem has been overcome by advances in alloy technology.Methods: In 259 patients who with total hip replacement, blood cobalt and chromium concentrations were measured with atomic absorption spectrophotometry over a period of four years after arthroplasty. Of the patients enrolled in the study, 131 had been managed with a METASUL@ cobalt-chromium alloy metal-on-metal bearing combination, while 128 had been given a SIKO-METO-SM2 1 @ cobalt-chromium alloy metal-on-metal combination. The control group consisted of 3 1 age-and gender-matched subjects.Resu1t.s: Compared with the controls, all the patients had higher cobalt and chromium levels. Cobalt concentrations were up to 50 times higher, while chromium concentrations were up to 100 times higher.Conclusions: Both systems showed evidence, in the whole-blood samples, of wear debris production by the implants. Therefore, patients managed with metal-on-metal bearing combinations should be carefully monitored in order to ensure that any local or systemic complications are detected early on.

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Section: Discussionmentioning

confidence: 99%

Four‐year study of cobalt and chromium blood levels in patients managed with two different metal‐on‐metal total hip replacements

Lhotka

Szekeres

Steffan

et al. 2003

Journal Orthopaedic Research

216

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“…It has been suggested that the carcinogenic effect could be due to metal wear (Case et al 1996). However, more recent studies have not confirmed the reports of an increased risk of leukemia or lymphoma for patients who have undergone joint implants (Gillespie et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Sealing effect of hydroxyapatite coating: A 12-month study in canines

Rahbek¹,

Overgaard²,

Jensen³

et al. 2000

Acta Orthopaedica Scandinavica

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“…1 The release of metal particles and ions from the McKee-Farrar prostheses was hypothesized to be the cause of the increased risk of lymphoma and leukemia. 6,7 The interest about the McKee-Farrar study was renewed since, metal-on-metal articulation from cobalt-chromiummolybdenum alloy was reintroduced into hip arthroplasty as an alternative to polyethylene and ceramic components in 1988. 8,9 The newer design, material, and fabrication technology of this second generation of metal-metal components are the basis of their good clinical results at medium-term follow-up reported in literature.…”

Section: Introductionmentioning

confidence: 99%

Ion release and chromosomal damage from total hip prostheses with metal‐on‐metal articulation

et al. 2003

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A prospective multicentric study was carried out in patients having metal-onmetal METASUL components (Sulzer Medica, Winterthur, Switzerland) in order to check the following null hypotheses: H1: The concentration of Co, Cr, Ni, and Mb in blood and urine is not modified by the implant of a hip prosthesis with METASUL components at 6 months. H2: The incidence of markers of chromosomal damage [sister chromatid exchanges (SCEs) and micronuclei (Mni)] in lymphocytes is not modified by the implant of METASUL components at 6 months. H3: The concentrations of Co, Cr, Ni, and Mb in blood and urine did not correlate with the incidence of the markers of chromosomal damage. The measurements showed a 2-fold increase of Co in blood, a 10-fold increase of Co in urine, a 1.5-fold increase of Cr in the blood, and a 3-fold increase of Cr in the urine at a follow-up of 6 months from the operation; there was also a significant increase in the Ni blood concentration at the 7 day checkup. The study cohort did not show any modification in the frequency of markers of chromosomal damage in the peripheral lymphocytes at any of the observation times. The amount of the SCEs and Mni recorded at all the observation times did not correlate with each other or with any of the ion levels measured in the blood and in the urine.

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Development of Hematopoietic Cancers After Implantation of Total Joint Replacement

Cited by 86 publications

References 6 publications

Four‐year study of cobalt and chromium blood levels in patients managed with two different metal‐on‐metal total hip replacements

Four‐year study of cobalt and chromium blood levels in patients managed with two different metal‐on‐metal total hip replacements

Sealing effect of hydroxyapatite coating: A 12-month study in canines

Ion release and chromosomal damage from total hip prostheses with metal‐on‐metal articulation

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