Sealing effect of hydroxyapatite coating: A 12-month study in canines

Rahbek, Ole; Overgaard, Søren; Jensen, Thomas Bo; Bendix, Knud; Søballe, Kjeld

doi:10.1080/000164700317362181

Cited by 41 publications

(43 citation statements)

References 41 publications

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“…This can be due only to a complete proximal sealing of the medullary cavity by circumferential bone ongrowth. Histological examination of retrieved autopsy specimens and animal studies have confirmed that this occurs with proximally osseointegrated stems (Tonino et al 1999, Rahbek et al 2000.…”

Section: Discussionmentioning

confidence: 99%

High survival rate of hydroxyapatite-coated hip prostheses100 consecutive hips followed for 10 years

Oosterbos¹,

Rahmy

Tonino

et al. 2004

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

High survival rate of hydroxyapatite-coated hip prostheses100 consecutive hips followed for 10 years

Oosterbos¹,

Rahmy

Tonino

et al. 2004

Acta Orthopaedica Scandinavica

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“…HA coatings reportedly provide bony ingrowth and improved initial implant stability [41,44]. Rahbek et al suggested enhanced fixation and reduction in radiolucencies are related to a superior sealing effect of the HA coating reducing wear particle migration into the bone-implant interface [37,38]. The sealing effect of HA coating is believed to reduce macrophage-induced osteolysis and prolong the lifespan of uncemented implants [14,38,41].…”

Section: Introductionmentioning

confidence: 99%

Inferior Survival of Hydroxyapatite versus Titanium-coated Cups at 15 Years

Stilling

Rahbek²,

Søballe³

2009

Clinical Orthopaedics &Amp; Related Research

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Hydroxyapatite (HA) particles have long been suspected to disintegrate from implant surfaces, become entrapped in joint spaces of orthopaedic bearing couples, and start a cascade leading to progressive polyethylene (PE) wear, increased osteolysis, and aseptic loosening. We compared cup revision at 15 years' followup in a randomized group of patients with 26 cementless THA components with titanium (Ti) versus first-generation HA coating. We also assessed radiographic PE wear and osteolysis to the 12-year followup or end point revision at a minimum of 5 years (mean, 10.9 years; range, 5-12.6 years). Two Ti-coated cups (17%) and eight HA-coated cups (57%) were revised at 15 years' followup. Femoral head penetration rate was 0.46 mm/year (standard deviation, 0.26) with the HAcoated cups (n = 12) and 0.38 mm/year (standard deviation, 0.14) with the Ti-coated cups (n = 10); we observed a wide variance of linear wear with the HA-coated cups. We also observed a positive association between high wear rate and revision, and between a high volume of osteolysis and revision. Our findings suggest inferior survival of mediumthickness spray-dried HA-coated cups with individual cases of excessive PE wear and premature cup failure. These findings apply to first-generation modular cups and may not apply to other cup designs and new HA-coating technologies.

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“…However, as shown in Table, the amounts and sizes of particles have varied between the different studies (Howie et al 1988, Goodman 1994, Bobyn et al 1995, Dowd et al 1995, Frökjaer et al 1995, Goodman et al 1995, 1999, Kraemer et al 1995, Allen et al 1996, Aspenberg and Herbertsson 1996, Shanbhag et al 1997, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, 2001, Bechtold et al 2001, Bi et al 2001b, Sundfeldt et al 2002. The time of introduction of the particles and the design of the studies also varied greatly.…”

Section: Particle Diseasementioning

confidence: 99%

“…The authors also postulated, however, that sealed interfaces could not withstand high loads of wear particles on a permanent basis and that with time osteolytic areas could form anywhere in the peri-implant region. In two different canine studies, Rahbek et al (2000Rahbek et al ( , 2001 found that PE particles injected into knees with HA-coated implants were unable to migrate into the interface.…”

Section: Individual or Genetic Variationsmentioning

confidence: 99%

“…It is very difficult to make any clear connection between PE particles and bone resorption based on animal studies (Howie et al 1988, Søballe et al 1992, Bobyn et al 1995, Dowd et al 1995, Allen et al 1996, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, Sundfeldt et al 2002.…”

Section: Polyethylenementioning

confidence: 99%

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