Development of Glassy Carbon Electrode Modified with Ruthenium Red-multiwalled Carbon Nanotubes for Simultaneous Determination of Epinephrine and Acetaminophen

Nadiki, Hadi Hassani; Noroozifar, Meissam; Khorasani-Motlagh, Mozhgan

doi:10.2116/analsci.30.911

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…EP acts as a cellular chemical messenger 11 , and many diseases are related to the change of its concentration. It is a hormone synthesized by the adrenal medulla of the adrenal glands 12 13 14 , it stimulates a series of actions of the sympathetic nervous system called “fight or flight” response 15 . EP controls the performance of the nervous system, and its abnormal levels affect the regulation of the blood pressure heart rate, and glycogen metabolism 8 16 .…”

mentioning

confidence: 99%

Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Mphuthi

Adekunle

Ebenso

2016

Sci Rep

106

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Glassy carbon electrode (GCE) was modified with metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, and the electrocatalytic properties were studied. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using FTIR, Raman and SEM techniques. The electrodes were characterized using cyclic voltammetry (CV) technique. The electrocatalytic behaviour of the electrode towards epinephrine (EP) and norepinephrine (NE) oxidation was investigated using CV and DPV. Result showed that GCE-MWCNT/Fe3O4/2,3-Nc, GCE-MWCNT/Fe3O429H,31H-Pc, GCE-MWCNT/ZnO/2,3-Nc and GCE-MWCNT/ZnO/29H,31H-Pc electrodes gave enhanced EP and NE current response. Stability study indicated that the four GCE-MWCNT/MO/Pc modified electrodes were stable against electrode fouling effect with the percentage NE current drop of 5.56–5.88% after 20 scans. GCE-MWCNT/Fe3O4/29H,31H-Pc gave the lowest limit of detection (4.6 μM) towards EP while MWCNT/ZnO/29H,31H-Pc gave the lowest limit of detection (1.7 μM) towards NE. The limit of detection and sensitivity of the electrodes compared well with literature. Electrocatalytic oxidation of EP and NE on GCE-MWCNT/MO/Pc electrodes was diffusion controlled with some adsorption of electro-oxidation reaction intermediates products. The electrodes were found to be electrochemically stable, reusable and can be used for the analysis of EP and NE in real life samples.

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mentioning

confidence: 99%

Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Mphuthi

Adekunle

Ebenso

2016

Sci Rep

106

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“…Nowadays, chemically and physically-modified electrodes are used to meet these demands. They include multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs/ GCE), 9 nano-TiO2/polymer coated GCE, 10 Ruthenium RedMWCNTs modified GCE 11 and gold nanoparticles modified carbon paste electrode. 12 Carbon materials are widely used in electroanalysis due to their considerable electrocatalytic activity.…”

Section: Introductionmentioning

confidence: 99%

Multi-walled Carbon Nanotubes/Graphite Nanosheets Modified Glassy Carbon Electrode for the Simultaneous Determination of Acetaminophen and Dopamine

Zhang

et al. 2015

ANAL. SCI.

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Graphite nanosheets prepared by thermal expansion and successive sonication were utilized for the construction of a multi-walled carbon nanotubes/graphite nanosheets based amperometric sensing platform to simultaneously determine acetaminophen and dopamine in the presence of ascorbic acid in physiological conditions. The synergistic effect of multiwalled carbon nanotubes and graphite nanosheets catalyzed the electrooxidation of acetaminophen and dopamine, leading to a remarkable potential difference up to 200 mV. The as-prepared modified electrode exhibited linear responses to acetaminophen and dopamine in the concentration ranges of 2.0 × 10 -6 -2.4 × 10 -4 M (R = 0.999) and 2.0 × 10 -6 -2.0 × 10 -4 M (R = 0.998), respectively. The detection limits were down to 2.3 × 10 -7 M for acetaminophen and 3.5 × 10 -7 M for dopamine (S/N = 3). Based on the simple preparation and prominent electrochemical properties, the obtained multiwalled carbon nanotubes/graphite nanosheets modified electrode would be a good candidate for the determination of acetaminophen and dopamine without the interference of ascorbic acid.

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Stimulation role of epinephrine in transcription of the melatonin synthesis key enzyme AANAT in the pineal gland of broilers

et al. 2018

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Melatonin is a crucial neurohormone synthesized in the pineal gland that influences the physiology of animals. The molecular mechanism of norepinephrine control of the synthesis of melatonin is well documented; however, few reports have described the effects of epinephrine on the synthesis of melatonin. In this study, the effect of epinephrine on melatonin synthesis was investigated by adding different concentrations of epinephrine or norepinephrine to broiler pineal glands cultured in vitro. In addition, we investigated how epinephrine regulates the synthesis of melatonin and the transcription of the key melatonin synthesis enzyme AANAT. We determined the abundance of melatonin, norepinephrine, and epinephrine in broiler serum and the mRNA expression levels of key enzymes under different light conditions. The minimum concentrations of epinephrine and norepinephrine required to recover the melatonin synthesis rhythm in pineal cells were 10 and 10 mol/L, respectively. Under various light durations, epinephrine reached maximum levels two hours earlier than melatonin. These results demonstrate for the first time that epinephrine can increase the synthesis of melatonin by increasing the transcription of AANAT.

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Development of Glassy Carbon Electrode Modified with Ruthenium Red-multiwalled Carbon Nanotubes for Simultaneous Determination of Epinephrine and Acetaminophen

Cited by 3 publications

References 50 publications

Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Multi-walled Carbon Nanotubes/Graphite Nanosheets Modified Glassy Carbon Electrode for the Simultaneous Determination of Acetaminophen and Dopamine

Stimulation role of epinephrine in transcription of the melatonin synthesis key enzyme AANAT in the pineal gland of broilers

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