Development of drug delivery systems for taxanes using ionic gelation of carboxyacyl derivatives of chitosan

Skorik, Yury А.; Golyshev, Anton A.; Kritchenkov, Andreii S.; Gasilova, Ekaterina R.; Poshina, Daria N.; Sivaram, Amal J.; Rangasamy, Jayakumar

doi:10.1016/j.carbpol.2017.01.025

Cited by 42 publications

(10 citation statements)

References 27 publications

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“…Moreover, the abundant active amine and hydroxyl groups in CS could offer many opportunities for chemical modification. In recent years, several chitosan-based PTX delivery systems have been developed, such as N -mercapto acetyl- N ′-octyl- O , N ′′-glycol chitosan micelles [ 13 ], 3,6- O , O ′-dimyristoyl chitosan micelles [ 14 ], folic acid–cholesterol–chitosan micelles [ 15 ], PTX conjugated trimethyl chitosan nanoparticles [ 16 ], palmitoyl chitosan nanoparticles [ 17 ], N -succinyl-chitosan nanoparticles [ 18 ] and PTX-loaded chitosan nanoparticles prepared by the nano-emulsion method [ 19 ]. However, chitosan with high molecular weight has poor solubility in aqueous medium at neutral pH, which limits its medical and pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Liang

Wang

et al. 2018

IJMS

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The present investigation aimed to develop a tumor-targeting drug delivery system for paclitaxel (PTX). The hydrophobic deoxycholic acid (DA) and active targeting ligand folic acid (FA) were used to modify water-soluble chitosan (CS). As an amphiphilic polymer, the conjugate FA-CS-DA was synthesized and characterized by Proton nuclear magnetic resonance (1H-NMR) and Fourier-transform infrared spectroscopy (FTIR) analysis. The degree of substitutions of DA and FA were calculated as 15.8% and 8.0%, respectively. In aqueous medium, the conjugate could self-assemble into micelles with the critical micelle concentration of 6.6 × 10−3 mg/mL. Under a transmission electron microscope (TEM), the PTX-loaded micelles exhibited a spherical shape. The particle size determined by dynamic light scattering was 126 nm, and the zeta potential was +19.3 mV. The drug loading efficiency and entrapment efficiency were 9.1% and 81.2%, respectively. X-Ray Diffraction (XRD) analysis showed that the PTX was encapsulated in the micelles in a molecular or amorphous state. In vitro and in vivo antitumor evaluations demonstrated the excellent antitumor activity of PTX-loaded micelles. It was suggested that FA-CS-DA was a safe and effective carrier for the intravenous delivery of paclitaxel.

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Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Liang

Wang

et al. 2018

IJMS

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“…Multi particulate systems are widely used as controlled release carriers . Spherical particles produced from Gelucire 43/01 and poly(ethylene glycol) was used as a matrix to carrier ketoprofen, collagen–chitosan nanoparticles with doxorubicin encapsulated was developed for cancer drug delivery, nanoparticles of two chitosan derivates produced by ionic gelation technique were developed as passive transport system for taxanes . As the previous examples cited, hybrid particles composed of two or more classes of material are being developed to combine multiple functionalities in a single delivery system .…”

Section: Introductionmentioning

confidence: 99%

“…The ionic gelation method are widely used due the high stability of synthesized particles, use of water‐based solutions, mild reaction condition without organic solvent and simple cost‐effective process . This technique has been adopted for natural carbohydrate polymers to produce biocompatible and biodegradable products . Many researches in ionic gelation are targeted at developing new drug delivery systems …”

Section: Introductionmentioning

confidence: 99%

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Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium

Vidart

Silva

Rosa

et al. 2017

J of Applied Polymer Sci

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Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X‐ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro‐resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919.

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“…O tempo de reação foi ajustado para 1-2 h até atingir a saturação, propondo uma reação simples e heterogênea. Além disso, os resultados mostraram ação anticoagulante similar para ambos os derivados SQ e GC e melhor compatibilidade hemo-compatível com SQ (SKORIK et al, 2017a).Mais estudos com o derivado de quitosana incluem nanopartículas de SQ como sistemas de liberação de fármacos para drogas anticâncer(SKORIK et al, 2017b), preparação de lipossomas multicamadas de quitooligossacarídeo e SQ (SEONG; YUN; PARK, 2018) e produção de micelas carregadas com siRNA usando esses copolímeros (ZHANG et al, 2016)…”

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Potencialidades da succinil quitosana como emulsificante e substituto de fração lipídica em massa de bolo

Rios¹

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Potencialidades da succinil quitosana como emulsificante e substituto de fração lipídica em massa de bolo Raquel Vallerio Rios Tese apresentada à Faculdade de Ciências Farmacêuticas da Universidade de São Paulo para a obtenção do título de Doutora em Ciências. Orientadora: Profa. Dra. Suzana Caetano da Silva Lannes AGRADECIMENTOS Primeiramente agradeço à Deus e a todos os "amigos" espirituais pela saúde, proteção e paciência me dada durante todo este percurso. Agradeço ao meu maior companheiro, Luís Henrique Ferreira de Moraes, do qual a vida me presenteou nessa jornada. Te agradeço pelo apoio, compreensão e paciência em todos os momentos desta tese, sempre me inspirando e me fazendo acreditar em mim mesma. AVE. À Professora Suzana C. S. Lannes por mais uma vez confiar em mim, me dando mais uma oportunidade de trabalharmos juntas, me apoiando e me ajudando em meu crescimento tanto profissional quanto pessoal. Serei sempre grata. À minha mãe, minha avó, meus irmãos (as), cunhados e à todos de minha família que me apoiaram nesta trajetória, mesmo não entendendo muito o que eu faço (rsrs) Às irmãs que ganhei ao longa da minha vida Ludmila Pina e aos ICs, estando alguns presentes ou não, pelo companheirismo no dia a dia, nos momentos de dúvidas e elucidações, nas conversas informais, nos cafés, nos almoços do bandejão, e principalmente pelo suporte nesta reta final. Aos funcionários do Departamento de Tecnologia Bioquímico-Farmacêutica da FCF, Tânia, Rose, Elza, Nilton, Alexandre e Ivani pelo apoio, pela paciência, e por todos os momentos de descontração durante os cafezinhos. Palavras-chave: Massas de bolo, derivados de quitosana, substituição de gordura, subproduto do krill ABSTRACT RIOS, R. V. Potentialities of succinyl chitosan as emulsifier and lipid fraction substitute on cake batter. 2018. 155p. Tese (Doutorado) -Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brasil.The need to create innovative products with functional characteristics is related to the demand of consumers which prioritize the well-being combined to a healthy and balanced diet. In this sense, the objective of this study was to evaluate the effects of the addition of succinyl chitosan (SQ) as an emulsifying agent and lipid fraction substitute on the qualities of cakes. Therefore, in chapter 1 a concise survey of the literature was carried out to understand the themes covered. In chapter 2, the SQ study was based on its obtaining and characterization for application in cakes. Infrared analysis and X-ray diffraction validated the deacetylation and succinylation reactions, and the thermal studies demonstrated thermal stability (above 300 °C), allowing the use of SQ in bakery products. The application of SQ suspension (2.0 g / 100 g) with reduced levels of fat (0 % (control), 25 %, 50 %, 75 % and 100 %) adjusting the amount of water, to adapt the batter's consistencies, resulted in cakes with similar viscosity parameters. The reduction of fat up to 50 % and presence of SQ contributed to the increase of the 2D area (from ...

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Development of drug delivery systems for taxanes using ionic gelation of carboxyacyl derivatives of chitosan

Cited by 42 publications

References 27 publications

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium

Potencialidades da succinil quitosana como emulsificante e substituto de fração lipídica em massa de bolo

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