Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium

Abstract

Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X‐ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro‐resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919.

A New Way to Promote Molecular Drug Release during Medical Treatment: A Polyelectrolyte Matrix on a Piezoelectric–Dielectric Energy Conversion Substrate

“…With electrical stimuli, the releases were accelerated but were still nicely fitted by Higuchi Equation where X is the fractional drug release, k 1 is a kinetic constant, and t is the release time, with the kinetic parameters increased from 0.0815 to 0.1425 for MB and from 0.0676 to 0.1386 for SF. The releases of the zwitterionic RhB and the peptide could only be well fitted using the first‐order equation shown as formula where X is the fractional drug release, k 2 is a kinetic constant, and t the release time, indicating that the interactions between the releasing molecules and the matrix dominated the release processes (Figure S5c,d,g,h, Supporting Information). The kinetic parameters increased from 0.0244 to 0.0667 for RhB without and with electrical stimuli, and from 0.0165 to 0.0577 for the peptide, again demonstrating apparent release accelerations by the piezoelectrical fields.…”

Avaliação Do Processo De Reticulação Térmica Sobre a Incorporação De Cetoprofeno Em Partículas De Sericina E Alginato

“…Desenvolvimento da blenda: Para a preparação da blenda de sericina e alginato foi realizado método similar ao proposto por Vidart et al (2018). Para isso, a solução de sericina com a concentração já ajustada passou por um processo de re-aquecimento em autoclave a 120 ºC e à pressão de 1 kgf/cm 2 , por 10 min.…”

“…Preparação das partículas: Para a obtenção das partículas, as soluções contendo o fármaco passaram pelo processo de gelificação iônica (Vidart et al, 2018), no qual a solução foi gotejada em solução de cloreto de cálcio (CaCl2) 3% sob agitação magnética, para que a gelificação ocorresse de forma instantânea. Após esta etapa as partículas foram colocadas sob agitação em jar test a 100 rpm durante 30 min, com o objetivo de completar a reticulação.…”

“…A combinação da sericina com o alginato de sódio para a formação de blendas é útil, pois, por ser gastrorresistente, ela evita que as propriedades do fármaco sejam afetadas pelo meio gástrico, além de possibilitar uma liberação controlada do mesmo (Vidart et al 2018). Porém, é possível que o objetivo pretendido não seja atingido somente com a blenda de sericina e alginato, sendo necessária a adição de agentes reticulantes à blenda polimérica.…”

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

“…Diclofenac sodium (DS) is a nonsteroidal anti-inflammatory drug, and is used to treat soft tissue injury due to its effectiveness and safety [ 1 , 8 , 9 ]. Studies have demonstrated that DS could penetrate the skin and distribute to the target tissue underlying the application site [ 8 , 10 , 11 ]. Generally, the commercially available DS is DS ointment, which cannot control the release of the drugs, resulting in dose-dependent problems, such as gastrointestinal, dermatological and the central nervous system toxicity [ 12 , 13 ].…”