Development of Colon-targeted Microsponges for the Treatment of Inflammatory Bowel Disease

Abstract

Janakidevi and Ramanamurthy: Development of Colon-targeted MicrospongesThe present study is aimed to develop and characterize microsponge-based novel colon-specific drug delivery systems containing 5-amino salicylic acid for the treatment of inflammatory bowel disease. Initially, microsponges of 5-amino salicylic acid were prepared by quasi-emulsion solvent diffusion method using Eudragit RS100, Eudragit S100 and Eudragit L100. Different formulations of microsponges using three acid resistant polymers, Eudragit S100, Eudragit L100, Eudragit RS100 in drug:polymer ratios of 1:1, 1:0.5, 1:0.25 with each polymer were prepared and evaluated for physicochemical, morphological characteristics and in vitro parameters. Among these nine formulations, ES1, EL1 and ERS1 were selected, sieved and compressed into tablets, T-ES1, T-EL1, T-ERS1 and evaluated. Among the 3 batches of tablet formulations prepared, T-ES1 showed the best release rate for the drug, which followed zero order release kinetics with diffusion case-II transport mechanism.

Design, Fabrication and Evaluation of Ketorolac Tromethamine Loaded Microsponge Based Colon Targeted Tablet

“…Authors have reported more cytotoxic efficacy of drug loaded microsponges over free drug. Janakidevi et al, 2018 [13] have fabricated mesalamine loaded microsponge for CTDD for treatment of IBD. Janakidevi et al, 2018 [14] have formulated diclofenac sodium loaded microsponge for CTDD for treatment of IBD.…”