The present study was aimed to formulated ketorolac tromethamine (KTM) loaded microsponge based colon targeted tablet for treatment of inflammatory bowel diseases. The Eudragit S-100 polymeric microsponges were utilized for delivery of drug. The drug loaded microsponges were fabricated by quasi-emulsion solvent diffusion technique and were evaluated with respect to particle size, production yield, entrapment efficiency, surface morphology and micromeritics properties. Which were revealed good production yield, drug entrapment efficiency and spherical morphology. The microsponge based tablet (MBT) was prepared by direct compression using lactose and evaluated with respect to drug content and in-vitro drug release kinetics. The MBTs showed desirable amount of drug (90-95 %) and drug release profile up to 10 hrs. The drug release from MBT was followed zero order kinetics with diffusion-controlled mechanism. Thus, present study could be novel approach for colon targeted delivery of KTM.
In this article we are providing a theoretical background for understanding different types of hepatotoxicities induced by drugs. Drug induced hepatotoxicity a potential complication of nearly every medication that is prescribed, because the liver is central to the metabolic disposition of virtually all drugs and foreign substances. Although drugs are metabolised without injury to the liver, many fatal and near fatal drug reactions occur each year. More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market.
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