Development of carboxymethyl cellulose/gelatin hybrid hydrogels via radiation-induced cross-linking as novel anti-adhesion barriers

Swilem, Ahmed E.; Oyama, Tomoko Gowa; Oyama, Kotaro; Kimura, Atsushi; Taguchi, Mitsumasa

doi:10.1016/j.polymdegradstab.2022.109856

Cited by 13 publications

(7 citation statements)

References 31 publications

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“…Various biomaterials, such as chitosan and derivative [ 179 ], hyaluronic acid(HA) [ 180 , 181 ], poly(ethylene glycol) (PEG) [ 182 , 183 ], gelatin [ 184 ], dextran (DEX) and derivative [ 185 ], PEO [ 186 ], and etc., have been prepared into hydrogels and demonstrated their efficiency in reducing POA. However, some extent of adhesion could still be founded because of their low mechanical strength.…”

Section: Possible Strategies For Preventing Adhesion By Using Biomate...mentioning

confidence: 99%

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Liao

Fan

2023

Bioactive Materials

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Section: Possible Strategies For Preventing Adhesion By Using Biomate...mentioning

confidence: 99%

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Liao

Fan

2023

Bioactive Materials

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“…By varying the radiation dose, the compression modulus of the hybrid hydrogel can be adjusted from 20 kPa to 100 kPa. [116] Radiationinduced polymerization can also make cellulose polymerize better in hydrogel network structure, thus improving mechanical properties. Gao has prepared cellulose paper-polyamidoxime hybrid hydrogel by polymerization with cellulose, which can adsorb uranium in seawater.…”

Section: Free Radical Polymerizationmentioning

confidence: 99%

“…treated carboxymethyl cellulose (CMC) and gelatin with radiation to generate hydrogels via the synergistic effect of radical polymerization and non‐covalent forces. By controlling the radiation dose, the compression modulus of the hydrogel can be regulated [116] …”

Section: Modification Of Cellulosementioning

confidence: 99%

Cellulose Dissolution, Modification, and the Derived Hydrogel: A Review

Wu,

Li,

Zhang

et al. 2023

ChemSusChem

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The development of cellulose‐based hydrogel has occupied a pivotal position in almost all walks of life. However, the native cellulose can not be directly used for preparing hydrogel due to the complex non‐covalent interactions. Some literature has discussed the dissolution and modification of cellulose but has yet to address the influence of the pretreatment on the as‐prepared hydrogels. Firstly, the "touching" of cellulose by derivative and non‐derivative solvents was introduced, viz., the dissolution of cellulose. Secondly, the "conversion" of functional groups on the cellulose surface by special routes, viz., the modification of cellulose. The above‐mentioned two parts were intended to explain the changes in physicochemical properties of cellulose by these routes and their influences on the subsequent hydrogel preparation. Finally, we summarized the “reinforcement” of cellulose‐based hydrogels by physical and chemical techniques, viz., improving the mechanical properties of cellulose‐based hydrogels and the changes in the multi‐level structure of the interior of cellulose‐based hydrogels.

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“…For example, toxic glutaraldehyde and hydrochloric acid are used to crosslink polyvinyl alcohol [ 44 ]. The most promising method of crosslinking is radiation crosslinking of polymers using radioactive isotopes of cobalt 60 Co, since there is no need to remove toxic crosslinkers in the process of radiation crosslinking [ 45 , 46 , 47 , 48 , 49 , 50 ]. Radiation crosslinking makes it possible to obtain soft and transparent gels at room temperature within a short period of time.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to the problem of targeted drug delivery in an organism. This will significantly reduce the toxicity of used pharmaceuticals and expand the range of their therapeutic, diagnostic, and medical application. This review presents a comparative description of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases. An analysis was made of most actual sources published for 2021–2022. The review is focused on the comparative characteristics of polymer gels in terms of their toxicity to cells and the release rate of drugs from nano-sized hydrogel systems, which are crucial initial features for their further possible application in mentioned areas of biomedicine. Different proposed mechanisms of drug release from gels depending on their structure, composition, and application are summarized and presented. The review may be useful for medical professionals, and pharmacologists dealing with the development of novel drug delivery vehicles.

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Development of carboxymethyl cellulose/gelatin hybrid hydrogels via radiation-induced cross-linking as novel anti-adhesion barriers

Cited by 13 publications

References 31 publications

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Cellulose Dissolution, Modification, and the Derived Hydrogel: A Review

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

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