Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Smagina, Veronika; Yudaev, Pavel; Kuskov, Andrey; Chistyakov, Evgeniy M.

doi:10.3390/pharmaceutics15030830

Cited by 12 publications

(7 citation statements)

References 112 publications

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“…Hydrogels with good mechanical strength and biocompatibility can be used in pharmacology. Polymeric hydrogels modified with active chemicals offer bioinert matrices and improve the regulatory and transport functions for drug delivery [ 156 ]. In this study, linear polyethyleneimine and hyaluronic acid were used to synthesize nanogels.…”

Section: Droplet-based Microfluidic Technology For Pharmaceutical App...mentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field.

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Section: Droplet-based Microfluidic Technology For Pharmaceutical App...mentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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“…It should be noted that h can be obtained as a natural result of harmonic mapping from a typical Euclidian space to SL(2R) [ 32 , 33 ]. Figure 2 a,b illustrates the dependencies of

on the dimensionless coordinates

and

of Ω for the two values imposed by means of

.…”

Section: Theoretical Modelmentioning

confidence: 99%

Theoretical—Experimental Approach of Chitosan/Quaternized Chitosan Nanofibers’ Behavior in Wound Exudate Media

Andreica,

Anisiei,

Iftime

et al. 2023

Pharmaceutics

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This study aimed to investigate the behavior of chitosan/quaternized chitosan fibers in media mimicking wound exudates to understand their capacities as wound dressing. Fiber analysis of the fibers using dynamic vapor sorption proved their ability to adsorb moisture up to 60% and then to desorb it as a function of humidity, indicating their outstanding breathability. Dissolution analyses showed that quaternized chitosan leached from the fibers in water and PBS, whereas only small portions of chitosan were solubilized in water. In media containing lysozyme, the fibers degraded with a rate determined by their composition and pH, reaching a mass loss of up to 47% in media of physiologic pH. Notably, in media mimicking the wound exudate during healing, they adsorbed moisture even when their mass loss due to biodegradation was high, whereas they were completely degraded in the media of normal tissues, indicating bioabsorbable dressing capacities. A mathematical model was constructed, which characterized the degradation rate and morphology changes of chitosan/quaternized chitosan fibers through analyses of dynamics in scale space, using the Theory of Scale Relativity. The model was validated using experimental data, making it possible to generalize it to the degradation of other biopolymeric systems that address wound healing.

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“…Among the varieties of multi‐stimuli‐responsive nanogels investigated in this discipline, magnetic thermo‐ responsive nanogels prove to be gaining more scope for research with fewer side effects and greater efficacy than chemo‐ and photodynamic treatment. This novel therapy uses polymer hydrogels containing magnetic nanoparticles to treat tumours under the influence of a high‐frequency alternating magnetic field [186] . Although nanogels are potential carriers for phototherapies against tumors, the long‐term harmful and adverse effects on organisms are not clearly understood which makes this discipline open to further research [187]…”

Section: Toxicity Of Nanogelsmentioning

confidence: 99%

“…This novel therapy uses polymer hydrogels containing magnetic nanoparticles to treat tumours under the influence of a high-frequency alternating magnetic field. [186] Although nanogels are potential carriers for phototherapies against tumors, the long-term harmful and adverse effects on organisms are not clearly understood which makes this discipline open to further research. [187]…”

Section: Novel Nanogel Therapy; Associated Toxicitymentioning

confidence: 99%

Stimuli‐Responsive and Multifunctional Nanogels in Drug Delivery

Ashwani,

Gopika,

Arun Krishna

et al. 2023

Chemistry & Biodiversity

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Nanogels represent promising drug delivery systems in the biomedical field, designed to overcome challenges associated with standard treatment approaches. Stimuli‐responsive nanogels, often referred to as intelligent materials, have garnered significant attention for their potential to enhance control over properties such as drug release and targeting. Furthermore, researchers have recently explored the application of nanogels in diverse sectors beyond biomedicine including sensing materials, catalysts, or adsorbents for environmental applications. However, to fully harness their potential as practical delivery systems, further research is required to better understand their pharmacokinetic behaviour, interactions between nanogels and bio distributions, as well as toxicities. One promising future application of stimuli‐responsive multifunctional nanogels is their use as delivery agents in cancer treatment, offering an alternative to overcome the challenges with conventional approaches. This review discusses various synthetic methods employed in developing nanogels as efficient carriers for drug delivery in cancer treatment. The investigations explore, the key aspects of nanogels, including their multifunctionality and stimuli‐responsive properties, as well as associated toxicity concerns. The discussions presented herein aim to provide the readers a comprehensive understanding of the potential of nanogels as smart drug delivery systems in the context of cancer therapy.

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Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Cited by 12 publications

References 112 publications

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Theoretical—Experimental Approach of Chitosan/Quaternized Chitosan Nanofibers’ Behavior in Wound Exudate Media

Stimuli‐Responsive and Multifunctional Nanogels in Drug Delivery

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