Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Liao, Jie; Li, Xiaoming; Fan, Yubo

doi:10.1016/j.bioactmat.2023.02.026

Cited by 18 publications

(36 citation statements)

References 327 publications

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“…Peritoneal adhesion development is a chronic degenerative process that can last for weeks. 12 Remesothelialization of the abdominal wall is impeded because the damaged site has been coated in fibrin. 4 Subsequently, peritoneal adhesions are compounded by angiogenesis and excessive collagen deposition.…”

Section: Prevention Of Postoperative Adhesion By Hd-based Cross-linke...mentioning

confidence: 99%

“…10,11 Biomaterial barriers in the form of films could physically isolate injured organs and tissues. 12,13 Despite their extensive use in clinics, solid film products such as Interceed and Seprafilm are still far from ideal. 14 These films require additional hemostasis and surgical sutures; otherwise, it will be difficult to cover injured areas.…”

Section: Introductionmentioning

confidence: 99%

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Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Lu,

Wang,

Kong

et al. 2024

ACS Appl. Mater. Interfaces

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Postoperative peritoneal adhesions are a prevalent clinical issue following abdominal and pelvic surgery, frequently resulting in heightened personal and societal health burdens. Traditional biomedical barriers offer limited benefits because of practical challenges for doctors and their incompatibility with laparoscopic surgery. Hydrogel materials, represented by hyaluronic acid gels, are receiving increasing attention. However, existing antiadhesive gels still have limited effectiveness or carry the risk of complications in clinical applications. Herein, we developed a novel hydrogel using polysaccharide hemoadhican (HD) as the base material and polyethylene glycol diglycidyl ether (PEGDE) as the cross-linking agent. The HD hydrogels exhibit appropriate mechanical properties, injectability, and excellent cytocompatibility. We demonstrate resistance to protein adsorption and L929 fibroblast cell adhesion to the HD hydrogel. The biodegradability and efficacy against peritoneal adhesion are further evaluated in C57BL/6 mice. Our results suggest a potential strategy for antipostoperative tissue adhesion barrier biomaterials.

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Section: Prevention Of Postoperative Adhesion By Hd-based Cross-linke...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Lu,

Wang,

Kong

et al. 2024

ACS Appl. Mater. Interfaces

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“…54 However, the pathophysiology of the different kinds of adhesion formation is still unclear as the tissue compositions are different between human cavities. 51 The complications with abdominal adhesions affect patients' quality of life and make future operations more difficult are major factors in addressing postsurgical adhesions in the abdominal cavity. Currently, the most special component of in the formation of postsurgical abdominal adhesions are the origins of mesothelial cells 16 and peritoneum large macrophages, 55 which have been introduced to initiate the early events in adhesion formation.…”

Section: Pathophysiologymentioning

confidence: 99%

“…Besides the FDA-approved barrier products, there are still a lot of studies working on or attempting to improve the properties of biomaterials to prevent adhesions. Liao et al (2023) summarized the studies for fabricating physical anti-adhesion membrane by manipulating the surface of the biomaterials and exploring the combination of multifunction's biomaterials in order to reduce postsurgical adhesions. 51 Erdi et al ( 2023) also take the advantages of current nanotechnology and introduced the most recent development of polymer types nanomaterials to utilize them as a more effective adjuvant surgical tool for surgical treatment, which has opened a new window in combining functional biomaterials to current clinical settings.…”

Section: Does Not Promote Infectionmentioning

confidence: 99%

Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions

Chen

Tang

Wang

et al. 2023

Bioengineering & Transla Med

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Postsurgical adhesions are a common complication of surgical procedures that can lead to postoperative pain, bowel obstruction, infertility, as well as complications with future procedures. Several agents have been developed to prevent adhesion formation, such as barriers, anti‐inflammatory and fibrinolytic agents. The Food and Drug Administration (FDA) has approved the use of physical barrier agents, but they have been associated with conflicting clinical studies and controversy in the clinical utilization of anti‐adhesion barriers. In this review, we summarize the human anatomy of the peritoneum, the pathophysiology of adhesion formation, the current prevention agents, as well as the current research progress on adhesion prevention. The early cellular events starting with injured mesothelial cells and incorporating macrophage response have recently been found to be associated with adhesion formation. This may provide the key component for developing future adhesion prevention methods. The current use of physical barriers to separate tissues, such as Seprafilm®, composed of hyaluronic acid and carboxymethylcellulose, can only reduce the risk of adhesion formation at the end stage. Other anti‐inflammatory or fibrinolytic agents for preventing adhesions have only been studied within the context of current research models, which is limited by the lack of in‐vitro model systems as well as in‐depth study of in‐vivo models to evaluate the efficiency of anti‐adhesion agents. In addition, we explore emerging therapies, such as gene therapy and stem cell‐based approaches, that may offer new strategies for preventing adhesion formation. In conclusion, anti‐adhesion agents represent a promising approach for reducing the burden of adhesion‐related complications in surgical patients. Further research is needed to optimize their use and develop new therapies for this challenging clinical problem.

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“…Consequently, there is much interest in the treatment of postoperative adhesion. To date, several strategies have been developed to relieve postoperative adhesion, such as implementing physical barriers, administering pharmacological agents locally or systemically, or a combination of the two. − Biomaterials in various physical forms, capable of physically isolating the wound tissues, have attracted significant interest, ,, but several problems remain open due to the complexity of the causes of postoperative adhesion, and the antiadhesive barriers prepared under the guidance of straightforward mechanisms are insufficient to fulfill the diverse clinical needs. , Safe and efficacious strategies for the clinical prevention of postoperative adhesion are still urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Zhou,

An,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

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Surgical bleeding and cumulative oxidative stress are significant factors in the development of postoperative adhesions, which are always associated with adverse patient outcomes. However, effective strategies for adhesion prevention are currently lacking in clinical practice. In this study, we propose a solution using polydopaminedecorated manganese dioxide nanoparticles (MnO 2 @PDA) with rapid hemostasis and remarkable antioxidant properties to prevent postsurgical adhesion. The PDA modification provides MnO 2 @PDA with enhanced tissue adhesiveness and hemocompatibility with negligible hemolysis. Furthermore, MnO 2 @PDA exhibits impressive antioxidant and free radical scavenging properties, protecting cells from the negative effects of oxidative stress. The hemostatic activity of MnO 2 @PDA is evaluated in a mouse truncated tail model and a liver injury model, with results demonstrating reduced bleeding time and volume. The in vivo test on a mouse cecal abrasion model shows that MnO 2 @PDA exhibits excellent antiadhesion properties coupled with alleviated inflammation around the damaged tissue. Therefore, MnO 2 @PDA, which exhibits high biosafety, rapid hemostasis, and beneficial antioxidant capacity, displays exceptional antiadhesion performance, holding great potential for clinical applications to prevent postoperative adhesion.

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Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Cited by 18 publications

References 327 publications

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions

Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

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Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Cited by 18 publications

References 327 publications

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions

Biosafe Polydopamine-Decorated MnO2 Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Contact Info

Product

Resources

About

Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention