Development of biodegradable bioactive glass ceramics by DLP printed containing EPCs/BMSCs for bone tissue engineering of rabbit mandible defects

Xu, Fangfang; Ren, Hui; Zheng, Mengjie; Shao, Xi; Dai, Taiqiang; Wu, Yanru; Tian, Li; Liu, Yu; Liu, Bin; Günster, Jens; Liu, Yaxiong; Liu, Yanpu

doi:10.1016/j.jmbbm.2019.103532

Cited by 33 publications

(36 citation statements)

References 50 publications

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“…Dispense plotting Filled with autologous blood, [128] oAEC g) [129] γ-irradiation [128] Sheep [128][129][130] Calvaria, [128] Sinus [129,130] ++ ∅ ΝΑ Dog [131] Mandible DLP ∅ ΝΑ Dog [146] Mandible − Bioglass Dispense plotting BMP/CS h) and BMP/ CS + rBMSCs j) NA Monkey [132] Alveolar +++ DLP EPC i) /BMSC NA Rabbit [147] Mandible + MgP k) Dispense plotting ∅ NA Rabbit [133] Calvaria −− Sr-HT-Gahnite l) Robocasting ∅ NA Rabbit [134] Calvaria ++ Composites PCL/PLGA MHDS Filling with collagen containing rhBMP-2 [85] UV [85] Rabbit [85,87] Calvaria, [87] Radius [85] ++ depends on the application site PCL/PLGA/β-TCP MHDS Filling with collagen containing rhBMP-2 [90] NA Rabbit [87,90] Calvaria ++…”

Section: +++mentioning

confidence: 99%

“…[116] SLA and DLP can be used to print photosensitive polymers and ceramics scaffolds (Figure 2). [77,146,147] Without a photoinitiator, the materials cannot be printed: this requirement excludes ceramics and metals alone. It is versatile and has an excellent resolution at ≈25 μm and accuracy (±0.1 mm according to 3D Hubs, see Table 3).…”

Section: (10 Of 17)mentioning

confidence: 99%

“…The vast majority of preclinical studies on large animals are for applications in the cranio-maxillofacial region, which represent ≈64% of the preclinical studies reported in Table 2). [18,67,78,[86][87][88][89][90][91][92][93][117][118][119][120][121][123][124][125][126][127][128][129][130][131][132][133][134][137][138][139][140]146,147] Around 32% of the preclinical studies reviewed in Table 2 are conducted in loadbearing sites. [12,53,54,63,64,73,74,[82][83][84][85]97,98,…”

Section: Application Sitementioning

confidence: 99%

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Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Garot

Bettega

Picart

2020

Adv Funct Materials

128

105

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Additive manufacturing (AM) allows the fabrication of customized bone scaffolds in terms of shape, pore size, material type, and mechanical properties. Combined with the possibility to obtain a precise 3D image of the bone defects using computed tomography or magnetic resonance imaging, it is now possible to manufacture implants for patient‐specific bone regeneration. This paper reviews the state‐of‐the‐art of the different materials and AM techniques used for the fabrication of 3D‐printed scaffolds in the field of bone tissue engineering. Their advantages and drawbacks are highlighted. For materials, specific criteria, are extracted from a literature study: biomimetism to native bone, mechanical properties, biodegradability, ability to be imaged (implantation and follow‐up period), histological performances, and sterilization process. AM techniques can be classified in three major categories: extrusion‐based, powder‐based, and vat photopolymerization. Their price, ease of use, and space requirement are analyzed. Different combinations of materials/AM techniques appear to be the most relevant depending on the targeted clinical applications (implantation site, presence of mechanical constraints, temporary or permanent implant). Finally, some barriers impeding the translation to human clinics are identified, notably the sterilization process.

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Section: +++mentioning

confidence: 99%

Section: (10 Of 17)mentioning

confidence: 99%

Section: Application Sitementioning

confidence: 99%

See 1 more Smart Citation

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Garot

Bettega

Picart

2020

Adv Funct Materials

128

105

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show abstract

“…Ceramics are good implant materials given that their chemical properties are similar to natural bone tissue [14]. Furthermore, the most commonly used ceramics-calcium hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP)-are biodegradable, osteoconductive and can be expanded by ceramic-based drug delivery systems to induce osteogenesis [77][78][79][80]. Consequently, in considering only the properties mentioned above, ceramics are the optimal material to create bone grafts similar to human natural bone.…”

Section: Ceramicsmentioning

confidence: 99%

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Riester

Borgolte

Csuk

et al. 2020

IJMS

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An aging population leads to increasing demand for sustained quality of life with the aid of novel implants. Patients expect fast healing and few complications after surgery. Increased biofunctionality and antimicrobial behavior of implants, in combination with supportive stem cell therapy, can meet these expectations. Recent research in the field of bone implants and the implementation of autologous mesenchymal stem cells in the treatment of bone defects is outlined and evaluated in this review. The article highlights several advantages, limitations and advances for metal-, ceramic- and polymer-based implants and discusses the future need for high-throughput screening systems used in the evaluation of novel developed materials and stem cell therapies. Automated cell culture systems, microarray assays or microfluidic devices are required to efficiently analyze the increasing number of new materials and stem cell-assisted therapies. Approaches described in the literature to improve biocompatibility, biofunctionality and stem cell differentiation efficiencies of implants range from the design of drug-laden nanoparticles to chemical modification and the selection of materials that mimic the natural tissue. Combining suitable implants with mesenchymal stem cell treatment promises to shorten healing time and increase treatment success. Most research studies focus on creating antibacterial materials or modifying implants with antibacterial coatings in order to address the increasing number of complications after surgeries that are mostly caused by bacterial infections. Moreover, treatment of multiresistant pathogens will pose even bigger challenges in hospitals in the future, according to the World Health Organization (WHO). These antibacterial materials will help to reduce infections after surgery and the number of antibiotic treatments that contribute to the emergence of new multiresistant pathogens, whilst the antibacterial implants will help reduce the amount of antibiotics used in clinical treatment.

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“…Because the ceramic cores should be removed, its open porosity should be greater than 30%. During the preparation of hollow turbine blades, the ceramic cores should be able to withstand a certain amount of impact; therefore, its flexural strength should be greater than 20 MPa [14][15][16][17][18][19].…”

Section: Introduction mentioning

confidence: 99%

Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores

et al. 2020

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Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing. The effects of sintering temperature on microstructure and physical and mechanical properties were investigated. The results show that the average particle size, shrinkage, bulk density, crystallite size, flexural strength, Vickers hardness, and nanoindentation hardness increased with the increase in sintering temperature, whereas the open porosity decreased with increasing sintering temperature. No change was observed in phase composition, chemical bond, atomic ratio, and surface roughness. For the sintered samples, the shrinkage in Z direction is much greater than that in X or Y direction. The optimum sintering temperature in argon atmosphere is 1350 ℃ with a shrinkage of 3.0%, 3.2%, and 5.5% in X, Y, and Z directions, respectively, flexural strength of 26.7 MPa, Vickers hardness of 198.5 HV, nanoindentation hardness of 33.1 GPa, bulk density of 2.5 g/cm 3 , and open porosity of 33.8%. The optimum sintering temperature was 70 ℃ higher than that sintering in air atmosphere when achieved the similar properties.

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Development of biodegradable bioactive glass ceramics by DLP printed containing EPCs/BMSCs for bone tissue engineering of rabbit mandible defects

Cited by 33 publications

References 50 publications

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores

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