Development of antiviral drugs against hepatitis B virus

Xu, Zaichao; Zhao, Kaitao; Jiang, Yingan; Xia, Yuchen

doi:10.1360/tb-2019-0038

Cited by 4 publications

(1 citation statement)

References 126 publications

(146 reference statements)

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“…. 2月5日, 德国美因茨大学和英国伦敦大学学院的研究团队在Lancet上发表的论文指出, 新冠病毒会触发过度和异常的非有效宿主免疫反应(或称为细胞因子风暴), 而具有良好安全性的靶向白细胞介素6受体的单克隆抗体Tocilizumab, 可用于抑制细胞因子风暴 [8] 获批用于治疗乙肝 [21] 和丙肝的聚乙二醇干扰素α-2a和α-2b可能用于刺激新冠病毒感染患者的先天性抗病毒反应而起到治疗作用 [3] , 并发现其在体外对SARS病毒感染具有抑制作用 [23] . 近期研究人员进一步发现, 氯喹在体外对新型冠状病毒也具有明显的抑制效果, 体外细胞试验EC 50 为1.13 μmol [10] , 被建议用于新型冠状病毒感染的临床预防及控制 [24] .…”

Section: 生物制剂unclassified

Recent research for COVID-19 drugs and therapies

Xing

Liu

2020

Chin. Sci. Bull.

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Section: 生物制剂unclassified

Recent research for COVID-19 drugs and therapies

Xing

Liu

2020

Chin. Sci. Bull.

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Natural Products: Review for Their Effects of Anti-HBV

Liu

2020

BioMed Research International

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Hepatitis B is a global infectious disease, seriously endangering human health. Currently, there are mainly interferons and nucleoside analogues treatment of hepatitis B in the clinic, which have certain therapeutic effects on hepatitis B, but their side effects and drug resistance are increasingly prominent. Therefore, it is urgently needed to discover and develop new anti-HBV drugs, especially natural products, which have novel, high efficiency, and low toxicity anti-HBV compounds with novel antiviral mechanisms. In this manuscript, the natural products (polysaccharides and 165 compounds) with the activity of antihepatitis B virus are discussed according to their chemical classes, including 14 phenylpropanoids, 8 flavonoids,12 xanthones, 13 anthroquinones, 47 terpenoids, 6 alkaloids, 15 enediynes, 11 aromatics, 18 phenylalanine dipeptides compounds, and 13 others. In addition, the anti-HBV mechanism and targets of natural product were also discussed. The aim of this review is to report new discoveries about anti-HBV natural products and to provide reference for researchers.

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Studies on the Anti-HBV Mechanism of Syringopicroside Based on Serum Metabolomics

Zhang

Zhu

et al. 2022

CPA

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Aims: Syringopicroside (SYR) is an iridoid monomer compound isolated from the traditional Chinese medicine clove leaf. HBV is a hepatotropic virus that can cause severe liver diseases, including acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Syringopicroside has a significant effect on anti-HBV, but the mechanism of action is still unclear. Methods: A metabolomics approach based on UPLC-G2-Si-HDMS was performed to analyze the serum biomarkers from HBV transgenic mice to find the biomarkers affected by Syringopicroside. Through the analysis of metabolic pathways, the key pathways of Syringopicroside to play a therapeutic role were explored to study its potential mechanism. Using network pharmacology, the "component-target-pathway" network of Syringopicroside in the treatment of hepatitis B was constructed, and combined with the results of metabolomics, the mechanism of action of Syringopicroside against HBV was discussed. Results: Serum metabolomics identified a total of 42 HBV-related biomarkers, of which 8 returned to normal levels after Syringopicroside treatment, involving a total of 6 metabolic pathways. 5 biomarkers returned to normal levels after lamivudine treatment, involving 2 metabolic pathways. Network pharmacology analysis showed that Syringopicroside in the treatment of hepatitis B mainly acts on 26 targets including MMP9, MAPK1 and SLC29A1, involving 4 pathways. Conclusion: This study elucidates the multi-target and multi-channel integration mechanism of Syringopicroside against HBV, lays a foundation for in-depth study of the anti-HBV mechanism of Syringopicroside, and also provides support for the development of innovative traditional Chinese medicines for the treatment of hepatitis B.

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Development of antiviral drugs against hepatitis B virus

Cited by 4 publications

References 126 publications

Recent research for COVID-19 drugs and therapies

Recent research for COVID-19 drugs and therapies

Natural Products: Review for Their Effects of Anti-HBV

Studies on the Anti-HBV Mechanism of Syringopicroside Based on Serum Metabolomics

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