Natural Products: Review for Their Effects of Anti-HBV

Liu, Xuqiang; Ma, Changyang; Liu, Zhenhua

doi:10.1155/2020/3972390

Cited by 16 publications

(15 citation statements)

References 56 publications

(21 reference statements)

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“…At 50 µg/mL, the C. xanthorrhiza extract reduced HBV DNA levels by 30% [65]. The xanthone compound mangiferin (53), isolated from Swertia mussotii, also induced a significant reduction in HBV DNA replication, with IC 50 values ranging from 0.01 to 0.13 mM [66,67]. Cao et al reported that dihydroxy-3,5-dimethoxyxanthone (54) and norswertianolin (55) isolated from Swertia yunnanensis exhibit inhibitory effects against HBV DNA replication in HepG2.2.15 cells, and methylation or glycosylation of the hydroxyl group of the compounds might be responsible for this inhibitory effect [38,66].…”

Section: Xanthone Compoundsmentioning

confidence: 99%

“…The xanthone compound mangiferin (53), isolated from Swertia mussotii, also induced a significant reduction in HBV DNA replication, with IC 50 values ranging from 0.01 to 0.13 mM [66,67]. Cao et al reported that dihydroxy-3,5-dimethoxyxanthone (54) and norswertianolin (55) isolated from Swertia yunnanensis exhibit inhibitory effects against HBV DNA replication in HepG2.2.15 cells, and methylation or glycosylation of the hydroxyl group of the compounds might be responsible for this inhibitory effect [38,66]. Another xanthone compound, 1,5,8-Trihydroxy-3-methoxyxanthone (56), isolated from Swertia delavayi, exhibited significant inhibitory activity against HBV DNA replication, with IC 50 values of 0.09 and 0.05 mM/L (SI of 10.89) [66,68].…”

Section: Xanthone Compoundsmentioning

confidence: 99%

“…from Swertia delavayi, exhibited significant inhibitory activity against HBV DNA replication, with IC50 values of 0.09 and 0.05 mM/L (SI of 10.89) [66,68].…”

Section: Xanthone Compoundsmentioning

confidence: 99%

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Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

Sadiea

Sultana

Chaki

et al. 2022

IJMS

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Hepatitis B virus infection (HBV) is one of the most common causes of hepatitis, and may lead to cirrhosis or hepatocellular carcinoma. According to the World Health Organization (WHO), approximately 296 million people worldwide are carriers of the hepatitis B virus. Various nucleos(t)ide analogs, which specifically suppress viral replication, are the main treatment agents for HBV infection. However, the development of drug-resistant HBV strains due to viral genomic mutations in genes encoding the polymerase protein is a major obstacle to HBV treatment. In addition, adverse effects can occur in patients treated with nucleos(t)ide analogs. Thus, alternative anti-HBV drugs of plant origin are being investigated as they exhibit excellent safety profiles and have few or no side effects. In this study, phytomedicines/phytochemicals exerting significant inhibitory effects on HBV by interfering with its replication were reviewed based on different compound groups. In addition, the chemical structures of these compounds were developed. This will facilitate their commercial synthesis and further investigation of the molecular mechanisms underlying their effects. The limitations of compounds previously screened for their anti-HBV effect, as well as future approaches to anti-HBV research, have also been discussed.

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Section: Xanthone Compoundsmentioning

confidence: 99%

Section: Xanthone Compoundsmentioning

confidence: 99%

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Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

Sadiea

Sultana

Chaki

et al. 2022

IJMS

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“…This HbeAg level is an indicator of predicting that the patient is whether infectious to others or not ( Grimm et al, 2011 ). Piperine, ursolic acid, oleanolic acid, and (+)-cycloolivil-4′-O-β-d-glucopyranoside have been testified to decrease the synthesis of HbsAg and HbeAg in many studies ( Zhou et al, 2015 ; Tshilanda et al, 2019 ; Liu et al, 2020 ). Quercetin has also been reported to decrease their synthesis by 60% ( Parvez et al, 2020 ).…”

Section: Mechanistic Insight Of Antiviral Activities Of the Plant Metabolites Derived From Medicinal Plantsmentioning

confidence: 99%

A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV

et al. 2021

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Currently, viral infection is the most serious health issue which causing unexpected higher rate of death globally. Many viruses are not yet curable, such as corona virus-2 (SARS-CoV-2), human immunodeficiency virus (HIV), hepatitis virus, human papilloma virus and so others. Furthermore, the toxicities and ineffective responses to resistant strains of synthetic antiviral drugs have reinforced the search of effective and alternative treatment options, such as plant-derived antiviral drug molecules. Therefore, in the present review, an attempt has been taken to summarize the medicinal plants reported for exhibiting antiviral activities available in Bangladesh along with discussing the mechanistic insights into their bioactive components against three most hazardous viruses, namely SARS-CoV-2, HIV, and HBV. The review covers 46 medicinal plants with antiviral activity from 25 families. Among the reported 79 bioactive compounds having antiviral activities isolated from these plants, about 37 of them have been reported for significant activities against varieties of viruses. Hesperidin, apigenin, luteolin, seselin, 6-gingerol, humulene epoxide, quercetin, kaempferol, curcumin, and epigallocatechin-3-gallate (EGCG) have been reported to inhibit multiple molecular targets of SARS-CoV-2 viral replication in a number of in silico investigations. Besides, numerous in silico, in vitro, and in vivo bioassays have been demonstrated that EGCG, anolignan-A, and B, ajoene, curcumin, and oleanolic acid exhibit anti-HIV activity while piperine, ursolic acid, oleanolic acid, (+)-cycloolivil-4′-O-β-d-glucopyranoside, quercetin, EGCG, kaempferol, aloin, apigenin, rosmarinic acid, andrographolide, and hesperidin possess anti-HBV activity. Thus, the antiviral medicinal plants and the isolated bioactive compounds may be considered for further advanced investigations with the aim of the development of effective and affordable antiviral drugs.

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“…The extracts of G. veitchiorum showed obvious inhibitory effects on RSV both in vivo and in vitro [123]. Lots of compounds isolated from Gentianeae had significantly anti-HBV and anti-HIV activity [79,[124][125][126][127].…”

Section: Antiviral Effectsmentioning

confidence: 99%

A Review on the Ethnomedicinal Usage, Phytochemistry, and Pharmacological Properties of Gentianeae (Gentianaceae) in Tibetan Medicine

Chi

Zhang

Gao

et al. 2021

Plants

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Gentianaceae is a large plant family and is distributed worldwide. As the largest tribe in Gentianaceae, Gentianeae contains 939–968 species, and the Qinghai-Tibet Plateau and adjacent areas are the main centers of diversity for Gentianeae. Species from the Gentianeae are widely used in traditional Tibetan medicine. In this review, a systematic and constructive overview of the information on botany, ethnomedicinal usage, phytochemistry, and pharmacological properties of Gentianeae in Tibetan medicine is provided. The results of this study are based on a literature search, including electronic databases, books, websites, papers, and conference proceedings. Botanical studies showed that Gentianeae includes the subtribe Gentianeae and Swertiinae, and several new genera and taxa have been identified. Approximately 83 species from Gentianeae were used in Tibetan medicine, among which Gentiana and Swertia constituted the largest number of species with 42 and 24 species, respectively. The species from Gentianeae are mainly used as Bangjian (སྤང་རྒྱན།), Jieji (ཀྱི་ལྕེ།), Dida (ཏིག་ཏ།), and Ganggaqiong (གང་གྰཆུང་།) in Tibetan medicine with different clinical applications. More than 240 formulas were found containing Gentianeae species with different attending functions. Phytochemical studies showed that the main active components of Gentianeae species are iridoids, xanthones, flavonoids, and triterpenoids. The bioactivities of plants from Gentianeae include hepatic protection, upper respiratory tract protection, joint and bone protection, glucose regulation, antibacterial, antioxidant, anticancer, and antiviral effects. This review will provide a reference for future research on natural resource protection, plant-based drug development, and further clinical investigation.

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Natural Products: Review for Their Effects of Anti-HBV

Cited by 16 publications

References 56 publications

Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV

A Review on the Ethnomedicinal Usage, Phytochemistry, and Pharmacological Properties of Gentianeae (Gentianaceae) in Tibetan Medicine

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