Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

Yambe, Tomoyuki; Abe, Yusuke; Imachi, Kou; Shiraishi, Yasuyuki; Shibata, Manabu; Yamaguchi, Tasuku; Wang, Quintian; Duan, Xudong; Liu, Hongjian; Yoshizawa, Makoto; Matsuki, H.; Sato, F.; Haga, You Ichi; Esashi, Masayoshi; Tabayashi, K; Mitamura, Yoshinori; Sasada, Hiroshi; Umezu, Mitsuo; Matsuda, Takehisa; Nitta, Shin Ichi

doi:10.1111/j.1525-1594.2004.07382.x

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…On the basis of this method, rotary blood pump with undulation pump was used in experiments to evaluate the arterial response to the rotary blood pump assistance (11,12). A healthy adult goat with UPVAD rotary blood pump was used in this experiment and results are shown in Fig.…”

Section: Undulation Pump Ventricular Assist Device (Upvad) and Ptt Chmentioning

confidence: 99%

Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

et al. 2009

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It is well known that the baroreflex system is one of the most important indicators of the pathophysiology in hypertensive patients. We can check the sensitivity of the baroreflex by observing heart rate (HR) responses; however, there is no simple diagnostic method to measure the arterial behavior in the baroreflex system. Presently, we report the development of a method and associated hardware that enables the diagnosis of baroreflex sensitivity by measuring the responses of both the heart and the artery. In this system, the measurements are obtained by monitoring an electrocardiogram and a pulse wave recorded from the radial artery or fingertip. The arterial responses were measured in terms of the pulse wave velocity (PWV) calculated from the pulse wave transmission time (PTT) from the heart to the artery. In this system, the HR change corresponding to the blood pressure change in time series sequence was observed. Slope of the changes in blood pressure and HR indicated the sensitivity of the baroreflex system of the heart. This system could also measure the sensitivity of the baroreflex system of an artery. Changes in the PWV in response to the blood pressure changes were observed. Significant correlation was observed in the time sequence between blood pressure change and PWV change after calculating the delay time by cross-correlation. The slope of these parameter changes was easily obtained and it demonstrated the sensitivity of the baroreflex system of an artery. We evaluated this method in animal experiments using rotary blood pump (RBP) with undulation pump ventricular assist device, and PTT elongation was observed in response to increased blood pressure with RBP assistance. Furthermore, when tested clinically, decreased sensitivity of the baroreflex system in hypertensive patients was observed. This system may be useful when we consider the ideal treatment and follow-up of patients with hypertension.

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Section: Undulation Pump Ventricular Assist Device (Upvad) and Ptt Chmentioning

confidence: 99%

Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

et al. 2009

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“…They proposed a left ventricular assist device control means which preserves right‐sided circulatory function at all times, while supporting peripheral perfusion. Tomoyuki Yambe et al (29) of the Tohoku University (Tohoku, Japan) reported on the development of an implantable undulation type ventricular assist device for the control of organ circulation. The ability to produce pulsation with this rotary pump suggests the ability to prevent multiple organ failure.…”

Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2004: A Year in Review

Malchesky¹

2005

Artificial Organs

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Mechanical circulatory support devices (MCSD) in Japan: current status and future directions

et al. 2005

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The current status and future directions of mechanical circulatory support devices (MCSDs) in Japan are reviewed. Currently used clinical MCSDs, both domestic and imported systems and continuous flow devices that are coming into the clinical arena are emphasized. Clinical MCSDs include the extracorporeal pulsatile Toyobo and Zeon systems and the implantable Novacor and HeartMate I VE. A thorough review is presented of single-ventricle continuous flow MCSDs such as the Terumo DuraHeart and the SunMedical EVAHEART and the biventricular Miwatec/Baylor systems that are on the horizon. The future directions in management of end-stage cardiac patients with MCSDs are discussed, focusing on (1) device selection - pulsatile versus continuous flow devices; (2) single-ventricle support, biventricular support, or replacement; (3) bridge to transplantation, destination therapy, or bridge to recovery; and (4) government regulatory processes and the medical industry. We hope to promote the quality of life (QOL) of end-stage cardiac patients as well as the medical industry in Japan.

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Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

Cited by 6 publications

References 17 publications

Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

Artificial Organs 2004: A Year in Review

Mechanical circulatory support devices (MCSD) in Japan: current status and future directions

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