Artificial Organs 2004: A Year in Review

Malchesky, Paul S.

doi:10.1111/j.1525-1594.2005.29048.x

Cited by 5 publications

(3 citation statements)

References 149 publications

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“…A growing number of other uses for these materials include medical and engineering materials [16]. To date, PHAs are aimed at medical devices and barrier packaging in addition to standard packaging and disposable uses [13]. The physical and mechanical properties of PHAs can be manipulated to provide a broad range of applications, in some cases matching the performance of engineered thermoplastics.…”

Section: Introductionmentioning

confidence: 99%

Characterization of new isolated Ralstonia eutropha strain A-04 and kinetic study of biodegradable copolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate) production

Chanprateep

Katakura

Visetkoop

et al. 2008

J Ind Microbiol Biotechnol

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A new isolated bacterial strain A-04 capable of producing high content of polyhydroxyalkanoates (PHAs) was morphologically and taxonomically identified based on biochemical tests and 16S rRNA gene analysis. The isolate is a member of the genus Ralstonia and close to Ralstonia eutropha. Hence, this study has led to the finding of a new and unexplored R. eutropha strain A-04 capable of producing PHAs with reasonable yield. The kinetic study of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] production by the R. eutropha strain A-04 was examined using butyric acid and gamma-hydroxybutyric acid as carbon sources. Effects of substrate ratio and mole ratio of carbon to nitrogen (C/N) on kinetic parameters were investigated in shake flask fed-batch cultivation. When C/N was 200, that is, nitrogen deficient condition, the specific production rate of 3-hydroxybutyrate (3HB) showed the highest value, whereas when C/N was in the range between 4 and 20, the maximum specific production rate of 4-hydroxybutyrate (4HB) was obtained. Thus, the synthesis of 3HB was growth-limited production under nitrogen-deficient condition, whereas the synthesis of 4HB was growth-associated production under nitrogen-sufficient condition. The mole fraction of 4HB units increased proportionally as the ratio of gamma-hydroxybutyric acid in the feed medium increased at any value of C/N ratio. Based on these kinetic studies, a simple strategy to improve P(3HB-co-4HB) production in shake flask fed-batch cultivation was investigated using C/N and substrate feeding ratio as manipulating variable, and was successfully proved by the experiments.

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Section: Introductionmentioning

confidence: 99%

Characterization of new isolated Ralstonia eutropha strain A-04 and kinetic study of biodegradable copolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate) production

Chanprateep

Katakura

Visetkoop

et al. 2008

J Ind Microbiol Biotechnol

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“…Extensive analytical, numerical and experimental investigations have been carried out to study various aspects of the VAD design and analysis, ranging from VAD control, effect of VAD cannulation sites, assisting action of different types of VADs on the native cardiovascular system and so on (Malchesky, 2005). In comparing the effect of different types of VAD pumping action on the native cardiovascular system, Vandenberghe et al (2003) used numerical simulation to study the unloading effect of a rotary pump under both constant flow and synchronous ending instance of U wave in ECG signal pulsatile flow conditions.…”

Section: Introductionmentioning

confidence: 99%

Numerical simulation of cardiovascular dynamics with different types of VAD assistance

Shi

Korakianitis

Bowles

2007

Journal of Biomechanics

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“… Artificial Organs 2004: A Year in Review (1) Development of Regenerative Cardiomyocytes From Mesenchymal Stem Cells for Cardiovascular Tissue Engineering (2) “Blogs” and “Wikis” are Valuable Software Tools for Communication Within Research Groups (3) Artificial Organs 2005: A Year in Review (4) A New Method for Manufacturing Cardiac Cell Sheets Using Fibrin‐coated Dishes and Its Electrophysical Studies by Optical Mapping (5). …”

mentioning

confidence: 99%

What You Tell Us About Artificial Organs

L'Abbate

2007

Artificial Organs

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Artificial Organs 2004: A Year in Review

Cited by 5 publications

References 149 publications

Characterization of new isolated Ralstonia eutropha strain A-04 and kinetic study of biodegradable copolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate) production

Characterization of new isolated Ralstonia eutropha strain A-04 and kinetic study of biodegradable copolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate) production

Numerical simulation of cardiovascular dynamics with different types of VAD assistance

What You Tell Us About Artificial Organs

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