Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

Yambe, Tomoyuki; Imachi, Kou; Shiraishi, Yasuyuki; Yamaguchi, Tasuku; Shibata, Manabu; Kameyama, Takeshi; Yoshizawa, Makoto; Sugita, Norihiro

doi:10.1111/j.1525-1594.2009.00864.x

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…The baroreflex is a bi-directional brain-body feedback arc composed of parallel, closed-loop branches that coordinate cardiovascular processes to control BP through changes in HR (i.e., the HR baroreflex loop), stroke volume (i.e., the stroke volume baroreflex loop), and vascular tone (i.e., the vascular tone baroreflex loop) ( 62 – 65 ). The efficiency of baroreflex regulation has been related to mood and stress ( 66 , 67 ).…”

Section: Introductionmentioning

confidence: 99%

Rest, Reactivity, and Recovery: A Psychophysiological Assessment of Borderline Personality Disorder

et al. 2018

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Difficulty regulating emotion is a cardinal feature of borderline personality disorder (BPD), yet little is known about the automatic psychophysiological processes involved in this phenotype. Inconsistent findings have emerged from studies that employed limited assessments (e.g., heart rate variability, skin conductance) of autonomic nervous system response to emotional contexts, and compared groups based on the presence or absence of BPD as a categorical diagnosis. This exploratory study assessed a comprehensive set of autonomic nervous system processes in 44 individuals (22 with BPD) at rest, in response to emotionally evocative stimuli, and during a subsequent recovery period. BPD was characterized with a dimensional measure of BPD symptom severity, as a well by categorical diagnosis. At baseline and across experimental tasks, higher heart rate was observed in those diagnosed with BPD compared to controls, and in those expressing greater BPD symptom severity. These effects, however, were fully mediated by differences in physical exercise. In contrast, during recovery from emotional activation, greater symptom severity predicted consistently higher levels of multiple sympathetic and parasympathetic processes compared to lower symptom severity. Overall, these findings suggest that the heart rate elevations sometimes observed in those diagnosed with BPD may be associated with individual and group differences in levels of physical exercise. Results further indicate that adaptive psychophysiological recovery responses following emotional challenge may be disrupted in proportion to BPD symptom severity, independently of exercise. Results highlight the utility of considering lifestyle factors and symptom severity in studies of emotional activation and regulation processes in BPD.

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Section: Introductionmentioning

confidence: 99%

Rest, Reactivity, and Recovery: A Psychophysiological Assessment of Borderline Personality Disorder

et al. 2018

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“…These system elements (i.e., heart rate [HR], vascular tone) may work independently or in tandem to generate fine-grained, real-time adjustments to optimize cardiovascular responding. Importantly, variability in each of these processes is linked through the baroreflex system, which is comprised of multiple parallel, closed-loop branches that control BP through changes in HR (i.e., the HR baroreflex loop), stroke volume (i.e., the stroke volume baroreflex loop), and vascular tone (i.e., the vascular tone baroreflex loop) (Casadei et al, 1992; Eckberg and Sleight, 1992; Vaschillo et al, 2012; Yambe et al, 2009). In addition, the baroreflex controls sympathetic nervous system activity.…”

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confidence: 99%

Immediate and Complex Cardiovascular Adaptation to an Acute Alcohol Dose

Buckman

Eddie

Vaschillo

et al. 2015

Alcoholism Clin & Exp Res

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Background The detrimental effects of chronic heavy alcohol use on the cardiovascular system are well established and broadly appreciated. Integrated cardiovascular response to an acute dose of alcohol has been less studied. This study examined the early effects of an acute dose of alcohol on the cardiovascular system, with particular emphasis on system variability and sensitivity. The goal was to begin to understand how acute alcohol disrupts dynamic cardiovascular regulatory processes prior to the development of cardiovascular disease. Methods Healthy participants (N = 72, age 21 to 29) were randomly assigned to an alcohol, placebo, or no-alcohol control beverage condition. Beat-to-beat heart rate (HR) and blood pressure (BP) were assessed during a low-demand cognitive task prior to and following beverage consumption. Between-group differences in neurocardiac response to an alcohol challenge (blood alcohol concentration ~ 0.06 mg/dl) were tested. Results The alcohol beverage group showed higher average HR, lower average stroke volume, lower HR variability and BP variability, and increased vascular tone baroreflex sensitivity after alcohol consumption. No changes were observed in the placebo group, but the control group showed slightly elevated average HR and BP after beverage consumption, possibly due to juice content. At the level of the individual, an active alcohol dose appeared to disrupt the typically tight coupling between cardiovascular processes. Conclusions A dose of alcohol quickly invoked multiple cardiovascular responses, possibly as an adaptive reaction to the acute pharmacological challenge. Future studies should assess how exposure to alcohol acutely disrupts or dissociates typically integrated neurocardiac functions.

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“…Tomoyuki Yambe et al. (38) of Tohoku University, Tohoku, Japan reported on the development of a method and associated hardware that enables the diagnosis of baroreflex sensitivity by measuring the responses of both the heart and the artery. The measurements were obtained by monitoring an electrocardiogram and a pulse wave recorded from the radial artery or fingertip.…”

Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2009: A Year in Review

Malchesky¹

2010

Artificial Organs

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In this editor's review, all articles published in 2009 are organized by category and briefly summarized. As Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level," we strive to publish the very best developments and clinical applications of artificial organ technologies in this broad and expanding field. In this editor's review, we aim to provide a reflection of the currently available worldwide knowledge that is intended to advance and improve human life while providing insight for continued application of technologies and methods of organ replacement, recovery, and regeneration. APHERESISClaudia Stefanutti et al. (1) of the University of Rome, Rome, Italy studied lowering lipoprotein Lp(a) using a reusable low density lipoprotein (LDL)-adsorber that allowed the removal of both LDL and Lp(a) from plasma. Two male patients with hyper-Lp(a) lipoproteinemia, without elevation of LDL-cholesterol, who had not responded to diet and medication were submitted to 50 LDL Lp(a) aphereses at weekly and biweekly intervals. Total cholesterol, LDL cholesterol, triglycerides, and Lp(a) plasma levels fell significantly. High density lipoprotein (HDL) cholesterol concentrations in plasma did not show a statistically significant change. Clinically, all sessions were well tolerated and no undesired reactions were reported. The adsorber's reusability for several sessions was confirmed.Claudia Stefanutti et al.(2) also reported on a multicenter study of therapeutic exchange (TPE) in patients with severe hypertriglyceridemia (sHTG). Seventeen patients who had not responded to conventional medical therapy (fat-free diet plus pharmaceutical interventions) were referred for TPE. Two hundred and seventeen TPE sessions were performed, and therapy is ongoing for 29.4% of the patients. After treatment, the mean plasma TG and total cholesterol concentrations were significantly reduced. The removal of triglyceride-richlipoproteins prevented relapses of acute pancreatitis. TPE provides a therapeutic option for preventing life-threatening sHTG. BLOOD SUBSTITUTESSabura Neya et al.(3) of Chiba University, Inage-Yayoi, Chiba, Japan evaluated the biological function of the core modified porphyrin isomers such as porphycene, corrphycene, and hemiporphycene. The iron complexes stoichiometrically coupled with apomyoglobin afford stable holoproteins. The oxygen affinity of the reconstituted myoglobins (Mb) changed over a 60 000-fold range depending on the

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Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance

Cited by 4 publications

References 12 publications

Rest, Reactivity, and Recovery: A Psychophysiological Assessment of Borderline Personality Disorder

Rest, Reactivity, and Recovery: A Psychophysiological Assessment of Borderline Personality Disorder

Immediate and Complex Cardiovascular Adaptation to an Acute Alcohol Dose

Artificial Organs 2009: A Year in Review

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