Development of an Acyl Sulfonamide Anti-Proliferative Agent, LY573636·Na

Abstract

The synthesis of 5-bromo-thiophene-2-sulfonic acid 2,4-dichlorobenzoylamide sodium salt on multikilogram scale is described. The initial clinical supplies were made using carbonyl diimidazole to converge the two fragments. A more efficient acid chloride process has been developed, which also provides better control of impurities and color throughout the synthesis.

Water‐soluble allyl and diallyl camphor sulfonamides‐based polyacrylamide copolymers for enhanced oil recovery

“…The monomes N ‐allyl camphor sulfonamide (CSAP) and N , N ‐diallyl camphor sulfonamide (CSDAP) were prepared by utilizing camphorsulfonic acid, thionyl chloride, allyl amine, and diallyl amine based on reported method . Obtained CSAP was white solid.…”

Water-soluble complexes of hydrophobically modified polymer and surface active imidazolium-based ionic liquids for enhancing oil recovery

“…N,N-Diallyl-2-dodecylbenzenesulfonamide (DBDAP) was prepared referring to the traditional methods [25]. Briefly, dodecylbenzenesulfonyl chloride was prepared by DB with excess SOCl 2 under reflux at 50 • C for 5 h. And the reaction of dodecylbenzenesulfonyl chloride and DAP using Et 3 N as acid binding agent in CH 2 Cl 2 was performed at 0-5 • C for 6 h. The product was washed three times with 1 wt% diluted hydrochloric acid, 1 wt% sodium hydroxide and saturated salt water, respectively, and then the solvent was removed under a vacuum.…”

Regioselective reaction of imidazole-2-thiols with N-sulfonylphenyldichloroacetaldimines: en route to novel sulfonylamino-substituted imidazo[2,1-b]thiazoles and thiazolo[3,2-a]benzimidazoles

“…[29][30][31][32] First of all, these are medicinally classical antagonists of folic acid having antimicrobial and antibiotic properties. [29][30][31][32][33][34] Also, we should take note of sulfonamides exerting antitumor [35][36][37] and anti-inflammatory activity, 38,39 neuroleptics, 40 anticonvulsants, diuretics, analgetics and antimigraine remedies. 41 Among sulfonamides there are efficient inhibitors of proteases, 41,42 COX-2 [43][44][45][46][47] and caspase inhibitors 48,49 associated with different diseases.…”