Development of a Surfactant/Platinum Composite for Sensitive Cardio‐selective Beta Blocker Detection and their Theoretical Studies

Abstract

An electrooxidative behavior of beta‐blocker drug esmolol was thoroughly investigated by using glassy carbon electrode modified with sodium dodecyl sulfate‐based platinum nanoparticles. The designed nanosensor exhibited remarkable electro‐catalytic effect by dramatically boosting the signal of the esmolol as compared to the bare electrode with detection limit up to picomolar. The effects of pH, scan rate, temperature, deposition potential, deposition time, effect of electrolyte and interfering agents were investigated to optimize conditions for getting intense signal of the analyte. Under optimized experimental conditions, a linear calibration plot for esmolol with a detection limit of 60 pM was obtained. The analyte sensing ability of the modified electrode was supported by the application of theoretical studies that showed favorable interaction between sodium dodecyl sulfate/platinum nanoparticles composite and esmolol. In this study, our aim was to developed a nanosensor for the sensitive detection of esmolol by electrochemical assay. We tried a lot of different modification style and modifiers for creating a sensitive nanosensor for esmolol. This nanosensor can be applied to the esmolol in serum sample without using any further separation, evaporation or precipitation steps. Application could apply in serum sample to test accuracy of our sensor and method. The high recovery results were observed in serum study.

PEDOT for Sensitive Electrochemical Detection of Trimetazidine Hydrochloride in Biological Fluids: Synthesis, Characterization and Mechanism Insights

“…Numerous papers have demonstrated that acidic media are the most suitable for the electrochemical characterization of drugs. 40,51,52 In the same context, the electrooxidation of mirtazapine (contain, just as TMZ, a piperazine moiety in its structure), discussed by Aǧin et al, 53 showed one sharp oxidation peak and one additional wave in acidic media in the anodic direction at 1.15 V and 1.3 V respectively; at pH 5.5, mirtazapine gives only a single and sharp peak at about 0.9 V which indicates that the transition from acidic to basic media can provide a total change in the electrooxidation behavior of the drug.…”

Recent advances in applications of surfactant‐based voltammetric sensors

“…Another nanomaterial with wide application in electrode design is platinum nanoparticles (PtNPs) (Hrapovic et al, 2004), which have been used to modify GCE along with SDS in the examination of the electrooxidative behavior of esmolol (Zahid et al, 2019). Significant electrocatalytic effects have been attributed to this platinum nanosensor, which has been enhanced the esmolol signal more effectively than the bare electrode.…”

Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non‐modified Glassy Carbon Electrode in Anionic Surfactant Media

“…Surfactants are quite effective in electrochemical analysis even when trace amounts are utilized. There are two advantages of using surfactants in electrochemistry, being adsorption at interfaces and aggregation into supramolecular structures [14, 16]. Surfactants also have protective effect against surface‐fouling and electro catalytic effect [17].…”