Development of a novel neodymium compound for in vivo fluorescence imaging

Abstract

We developed a novel fluorescent probe that contains the neodymium(III) complex moiety and fluorescein moiety. This probe can emit long-lived near-infrared luminescence derived from a Nd ion through excitation of the fluorescein moiety with visible light (lambda(ex) = 488 nm, lambda(em) = 880 nm, lifetime = 2.3 micros). These results indicate the possibility of the probe as a candidate for in vivo fluorescence molecular imaging.

Fluorescence Lifetime Measurements and Biological Imaging

“…Microscopy and in vivo imaging with lanthanides is a growing area of research and a number of lanthanide constructs for microscopy and in vivo imaging have been proposed 455,456. An example of a compound emissive in NIR and potentially suitable for in vivo imaging is shown in Fig.…”

Highly Luminescent, Water‐Soluble Lanthanide Fluorobenzoates: Syntheses, Structures and Photophysics, Part I: Lanthanide Pentafluorobenzoates

“…Therefore, in our work we focus on an investigation of the syntheses, structures, and photophysical properties of lanthanide fluorobenzoates with different degrees of fluorination. Herein, we selected pentafluorobenzoates[ Ln(pfb) 3 (H 2 O) x ], in which the ligand has the maximum degree of fluorination, as the starting point of our study.T hey are noted to emit in both the visible and IR ranges, [17][18][19][20][21][22][23] but the published data are incomplete and contradictory.B y using this example, we developed am ethodological approach for the investigation of these compounds and revealed the main patternso ft heir structural and luminescentbehavior.…”

NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging

“…These features are similar to our previous compound [4AMF-DOTA(Nd)], which has a fluorescence at 880 nm from excitation by 488 nm light. [15] . In addition, an undesirable fluorescence around 525 nm from the antenna moiety present in 4AMF-DOTA(Nd) was eliminated by using a non-fluorescent antenna moiety in PAN-DOTA(Yb).…”