Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders

Gallo, Loreana; Piña, Juliana; Bucalá, Verónica; Allemandi, Daniel Alberto; Ramírez-Rigo, María Verónica

doi:10.1016/j.powtec.2013.03.011

Cited by 29 publications

(22 citation statements)

References 43 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, a higher concentration of extract (Factor E) means less liquid to evaporate in the drying and therefore more solids in a drop which produces an increase in particle size and a final product with a more fluid flow of powder [30,31,42,45,46]. The effect of total solids content on flowability is in accordance with the results reported by Moreira et al [42] and Gallo et al [27].…”

Section: Angle Of Reposesupporting

confidence: 87%

“…Fluid extract at the defined concentration and silicon dioxide (drying coadjuvant), were used as ingredients for the SD process, [18,[25][26][27][28][29] in the proportion established by the SED (table 2). The suspension obtained was stirred to homogenize the dispersion for 30 min (magnetic stirrer IKA C-MAG HS 7); the stirring was maintained during the process.…”

Section: Sample Preparation and Characterization Prior To Sd Processmentioning

confidence: 99%

See 1 more Smart Citation

Dry Powder Formulation From Physalis Peruviana L. Fruits Extract With Antidiabetic Activity Formulated via Co-Spray Drying

2019

View full text Add to dashboard Cite

Objective: To establish the drying conditions of an extract of fruits of Physalis peruviana using spray drying (SD) technique by applying a statistical experimental design (SED), to obtain powders for direct compression, retaining the antidiabetic activity. Methods: A 2[6-2] fractional factorial SED was used to get a suitable SD operating conditions to produce powder extract of P. peruviana with high process yield, acceptable moisture content, good flowability, low hygroscopicity and satisfactory morphological and particle size. Operating variables studied were air inlet temperature, atomization air flow rate, feed-rate pump, aspiration rate, extract concentration and coadjuvant proportion. P. peruviana powder obtained under the operating conditions selected was evaluated by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and by in vitro α-amylase inhibition assay, to prove that the antidiabetic activity was remained after the SD. Results: Injection temperature (120 °C), atomization air flow rate (600 l/h), pump setting (5 %), aspirator setting (100 %), extract concentration (7.5 % p/p) and extract: coadjuvant ratio (1:0.75), were the operational conditions selected. Dry extract showed an amorphous state by XRPD and a probable protective effect of coadjutant on the extract, characterized by DSC and the antidiabetic in vitro assay. Antidiabetic activity of the extract remained after its transformation to a solid state by SD in the chosen conditions. Conclusion: The results suggest that coprocessed extract could be used for the production of compressed solids or employed as an intermediate herbal product for the treatment of diabetes.

show abstract

Section: Angle Of Reposesupporting

confidence: 87%

Section: Sample Preparation and Characterization Prior To Sd Processmentioning

confidence: 99%

Dry Powder Formulation From Physalis Peruviana L. Fruits Extract With Antidiabetic Activity Formulated via Co-Spray Drying

2019

View full text Add to dashboard Cite

show abstract

“…Additionally, its association with arabic gum or modified starch, potentiated the silicon dioxide thixotropic effect allowing the suspension to be thick and slightly stable during the drying process. Reports have demonstrated the improved powder flowability, compressibility and compactibility not only of isolated compounds, but also of plant extracts [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Development and characterization of a novel standardized propolis dry extract obtained by factorial design with high artepillin C content

Marquiafável¹,

Nascimento²,

Barud³

et al. 2015

J Pharm Technol Drug Res

View full text Add to dashboard Cite

Background: Besides the known propolis biological activities, widely reported in many scientific studies, new findings in animal models have opened new fields for propolis application. Recently, there has been an increased interest in dried extracts based on natural products including propolis, as the product in the dry presentation shows several advantages. Therefore, standardizing a more soluble dry extract and allowing the production of human dosage forms are of great interest. In this context, this work aimed to develop a propolis dry extract with high propolis and artepillin C contents. Methods: The experiments followed a Box-Behnken design to study the effects of the process on the physicochemical properties of the powder using a spray drying equipment. The following drying excipients were used: silicon dioxide with arabic gum (encapsulating system A) and modified starch (encapsulating system B). Furthermore, physicochemical characterization, particle morphology by scanning electron microscopy and antibacterial assay of the samples were carried out. Results: The results revealed that all variables of the process did not influence significantly propolis and flavonoid content, moisture and angle of repose in the encapsulating system A (arabic gum and silicon dioxide). For the encapsulating system B (modified starch and silicon dioxide), it was observed that the propolis content, flavonoid content, density, moisture and angle of repose were influenced significantly by the variables of the drying process parameters. Finally, p-coumaric acid, cinnamic acid and artepillin C were affected by the process conditions of system A, while, these biomarkers were not affected by the encapsulating system B. Both propolis dry extracts obtained were active against Staphylococcus aureus. Conclusions: This study evidenced different encapsulating systems lead to different effects, depending on the drying process parameters. Both encapsulating systems allowed to obtain a standardized propolis extract with high flavonoid content and the expected amounts of artepillin C. Also, they maintained the antibacterial activity of propolis.

show abstract

“…Usualmente, as plantas medicinais são utilizadas em diversas formas, mas as indústrias farmacêuticas têm especial interesse pelos extratos vegetais secos uma vez que as formas farmacêuticas sólidas normalmente recobertas oferecem muitas vantagens sobre as formas convencionais líquidas, tais como menores custos de armazenamento, maior concentração e estabilidade das substâncias ativas (Gallo et al, 2013).…”

Section: Introductionunclassified

Taxa de evaporação em função do processo de recobrimento de grânulos de quebra pedra

Rocha¹,

Alsina²,

Silva³

et al. 2014

Rev. bras. eng. agríc. ambient.

View full text Add to dashboard Cite

R E S U M OObjetivou-se, neste trabalho, avaliar o efeito das variáveis do processo de recobrimento de grânulos de quebrapedra (Phyllantus niruri L.) com suspensão polimérica em secador de leito de jorro convencional sobre a taxa de evaporação. Os grânulos foram obtidos a partir do processo de granulação por via úmida do extrato seco de quebra pedra e, como ligante, o PVP-K30. A suspensão polimérica à base de Eudragit® foi atomizada sobre o leito de partículas. Foi realizado um delineamento composto central rotacional (DCCR) simétrico e de segunda ordem constituído de um fatorial 23, com 8 ensaios, 3 pontos centrais e 6 pontos axiais, totalizando 17 experimentos. Os resultados mostraram que a vazão de suspensão influencia positivamente a taxa de evaporação. As variáveis pressão e temperatura não apresentaram influência significativa na taxa de evaporação. Foram encontrados modelos estatisticamente significativos e preditivos para taxa de evaporação. Em se tratando das interações entre as variáveis do processo observa-se que vazão/temperatura, pressão/vazão e pressão/temperatura exercem efeito significativo sobre a taxa de evaporação.Evaporation rate as a function of the process of coating of stone-breaker granules A B S T R A C TThe objective of this study was to evaluate the effect of the variables of the coating process of stone-breaker (Phyllanthus niruri L.) granules with polymeric suspension in a conventional spouted bed dryer whilst on the evaporation rate. The granules were obtained from the granulation process by wet dry extract of breaking stone, using PVP-K30 as a binder. The suspension of the base polymer Eudragit® was atomized on the bed of particles through the atomized dual-fluid, located at the top of the column. A central rotatable composite design (CRCD) symmetrical and of second order was realized, constituted of a factorial 23, with 8 tests, 3 central points, and 6 axial points, totalizing 17 experiments. The results showed that the evaporation rate correlated positively with the suspension flow rate, while pressure and temperature had no significant effect on the evaporation rate. The experimental design enabled the development of statistically significant predictive models for the evaporation rate. Regarding the effect of the interactions between process variables on the evaporation rate, flow/temperature, pressure/flow and pressure/temperature significantly affected the evaporation rate.Palavras-chave: secagem leito de jorro suspensão polimérica

show abstract

Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders

Cited by 29 publications

References 43 publications

Dry Powder Formulation From Physalis Peruviana L. Fruits Extract With Antidiabetic Activity Formulated via Co-Spray Drying

Dry Powder Formulation From Physalis Peruviana L. Fruits Extract With Antidiabetic Activity Formulated via Co-Spray Drying

Development and characterization of a novel standardized propolis dry extract obtained by factorial design with high artepillin C content

Taxa de evaporação em função do processo de recobrimento de grânulos de quebra pedra

Contact Info

Product

Resources

About