Development of a miniature bioreactor for continuous culture in a space laboratory

Walther, Isabelle; Schoot, B.H. van der; Jeanneret, S.; Arquint, Ph.; Rooij, N. F. de; Gass, Volker; Bechler, B.; Lorenzi, Giorgio; Cogoli, Augusto

doi:10.1016/0168-1656(94)90144-9

Cited by 45 publications

(28 citation statements)

References 10 publications

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“…The needs for scale-down systems resulted in the last decade in the development of successful novel micro-bioreactor ($2-3 ml) designs, such as those described by Walther et al (1994), Kostov et al (2001), Girard et al (2001) and some others in the tens of millilitres scale (Puskeiler et al 2005). Platform technologies can effectively decrease the time required to develop highproducing cell lines for biotherapeutics, as well discussed in two recent reviews (Lye et al 2003, Kumar et al 2004.…”

Section: Introductionmentioning

confidence: 99%

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

et al. 2006

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A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of c-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in c-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o $482 to Re o $1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area.

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Section: Introductionmentioning

confidence: 99%

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

et al. 2006

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“…In particular, new materials had to be selected and tested for their biocompatibility. The instrument has passed all space and biological qualification tests and has been successfully used in an experiment selected by the European Space Agency (ESA) for the International Microgravity Laboratory-2 Mission in Spacelab in July 1994 [6]. This rather complex structure is micromachined in silicon requiring only four masks and combining various techniques such as fusion bonding, KOH etching, anisotropic (CUF-based plasma) and isotropic (F-based plasma) dry etching, and sacrificial layer etching.…”

Section: Micro Instrumentation For Space Researchmentioning

confidence: 99%

Examples of Silicon Based Microsystems

Rooij

1995

IEEJ Trans. SM

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“…This is, however, strongly dependent on the type of system and, as mentioned earlier, the production volume. Examples of space applications are the space micro-bioreactor as developed by van der Schoot et al [48], and the previously mentioned sensor array system [11]. Whereas the first system is meant to be a small-size, lowpower experimentation setup for biological experiments, the second one is meant to be incorporated in the life support systems for astronauts.…”

Section: Applicationsmentioning

confidence: 99%

Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications

Berg

Lammerink

1998

Topics in Current Chemistry

197

102

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In this contribution three aspects of miniaturized total analysis systems (mTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling-and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic-and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a mTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of mTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.

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Development of a miniature bioreactor for continuous culture in a space laboratory

Cited by 45 publications

References 10 publications

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

Examples of Silicon Based Microsystems

Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications

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