Development of a mass-producible on-chip plasmonic nanohole array biosensor

Nakamoto, Kohei; Kurita, Ryoji; Niwa, Osamu; Fujii, Toshiyuki; Nishida, Munehiro

doi:10.1039/c1nr10883b

Cited by 66 publications

(62 citation statements)

References 48 publications

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“…The FWHM value increases monotonically with the increasing nanowell depth, while FH shows a descending trend. [ 34 ] It is worth noting that the narrowest linewidth of 9.4 nm is achieved in this study from a 40 nm nanowell depth. This value is approximately 1.6 times larger than the one obtained in the previous section and also much higher than many other high-performance plasmonic sensors, such as the bimetallic Au on Ag nanohole arrays (about 9 × 10 −3 nm −1 ) [ 33 ] and the Au bottom-fi lled nanohole arrays (19.6 × 10 −3 nm −1 ).…”

Section: Optimization Of Nanowell Depthmentioning

confidence: 60%

High‐Performance Plasmonic Sensors Based on Two‐Dimensional Ag Nanowell Crystals

Zhang

Chang

et al. 2014

Advanced Optical Materials

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Both resonance modes exhibit a tight confi nement of the exponentially decaying electromagnetic fi eld. Hence the optical properties can be highly sensitive to small changes of the refractive index (RI) in close proximity to the metal surface. A change of the effective RI resulting from molecular binding events at the surface of the SP-based sensor, therefore, can be directly detected in real time as the changes in optical intensity, [13][14][15][16][17] wavelength, [18][19][20] or angle. [ 21,22 ] In conventional surface plasmon resonance (SPR) detectors, such as the commercially available BIAcore, light is coupled into SPP modes on a fl at, continuous gold fi lm via a prism-based coupling, known as the Kreschmann confi guration. [ 23 ] This has proved to be a highly effective tool in clinical diagnosis, but the cumbersome prism coupling remains diffi cult to integrate into cost-effective, high-throughput, and portable devices for rapid bioanalytical measurements. Therefore, plamonic sensors that do not require any bulky coupling optics are highly desired.From this point of view, nanostructured free-electron metals are of increasing interest. For one thing, they can solve the momentum mismatch between photons and SPs, [ 24 ] which makes them be resonantly excited by light without the need for any couplers; for another, continuing advances in nanoparticle synthesis and nanofabrication technologies, [25][26][27][28] as well as the development in theories make it possible to rationally design and prepare plasmonic devices with optimal optical properties and thus enhanced sensing performance. Currently, nanostructured plasmonic sensors can be classifi ed into two main groups: colloidal nanoparticles and surface-bound nanostructures. The surface-bound nanostructures offer at least two attractive features. One is that their optical properties can be readily tuned by controlling the shape, size, composition, and spacing of the nanostructures. The other one is that they are free of capping agents or stabilizers used in colloidal nanoparticle synthesis, which makes them readily accessible for functionalization with specifi c receptors or ligands. These advantages make them the focus of research in the fi eld of plasmonic sensors.When evaluating an SP-based sensor, the refractive index sensitivity (RIS) is mostly considered. The RIS of a wavelengthinterrogated sensor is defi ned in terms of the change in peak A high-performance plasmonic biosensor based on two-dimensional (2D) Ag nanowell crystals is rationally designed and fabricated by colloidal lithography. The crystals act as 2D metallic gratings that directly couple incident photons to surface plasmon polaritons (SPPs). The nanowell sizes are properly tuned to enable coupling between the SPPs and Raleigh anomalies, which proves to greatly contribute to sharp refl ectance dips. Other geometric parameters including the nanowell depth and the lattice constant are respectively adjusted to optimize the lineshape and sensitivity. These inferences and experimental results a...

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Section: Optimization Of Nanowell Depthmentioning

confidence: 60%

High‐Performance Plasmonic Sensors Based on Two‐Dimensional Ag Nanowell Crystals

Zhang

Chang

et al. 2014

Advanced Optical Materials

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“…Nakamoto et al showed that the metal thickness does not signicantly change the resonance wavelength of the metal-solution plasmon band. 21 In contrast to this enhanced transmission, optically thin lms show signicantly suppressed transmission. [22][23][24] Surface roughness will have a strong effect on the bandwidth of the plasmon band, 25 but does not change the resonance wavelength.…”

Section: Introductionmentioning

confidence: 95%

Tuning the 3D plasmon field of nanohole arrays

et al. 2013

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Modern photonics is being revolutionized through the use of nanostructured plasmonic materials, which confine light to sub-diffraction limit resolution providing universal, sensitive, and simple transducers for molecular sensors. Understanding the mechanisms by which light interacts with plasmonic crystals is essential for developing application-focussed devices. The strong influence of grating coupling on electromagnetic field distribution, frequency and degeneracy of plasmon bands has now been characterized using hexagonal nanohole arrays. An equation for nanohole arrays was derived to demonstrate the strong influence of incidence and rotation angle on optical properties of 2D plasmonic crystals such as nanohole arrays. Consequently, we report experimental data that are in strong agreement with finite difference time-domain (FDTD) simulations that clearly demonstrate the influence of the grating coupling conditions on the optical properties (such as plasmon degeneracy and bandwidth), and on the distribution of the plasmon field around nanohole arrays (including tuneable penetration depths and highly localized fields). The tuneable 3D plasmon field allowed for controlled sensing properties and by increasing the angle of incidence to 30 degrees, the resonance wavelength was tuned from 1000 to 600 nm, and the sensitivity was enhanced by nearly 300% for a protein assay using surface plasmon resonance (SPR) and by 40% with surface-enhanced Raman scattering (SERS) sensors.

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“…Recent work has now introduced reflection-mode measurements also for nanoplasmonic sensors. 90,91 Using template-stripping methods, backside reflection-mode nanoplasmonic sensor has also been demonstrated, 92 wherein the optical paths and fluidic paths are decoupled as with conventional SPR.…”

Section: Plasmon Spectroscopy For High-resolution Biosensingmentioning

confidence: 99%

Promises and challenges of nanoplasmonic devices for refractometric biosensing

et al. 2013

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Optical biosensors based on surface plasmon resonance (SPR) in metallic thin films are currently standard tools for measuring molecular binding kinetics and affinities – an important task for biophysical studies and pharmaceutical development. Motivated by recent progress in the design and fabrication of metallic nanostructures, such as nanoparticles or nanoholes of various shapes, researchers have been pursuing a new generation of biosensors harnessing tailored plasmonic effects in these engineered nanostructures. Nanoplasmonic devices, while demanding nanofabrication, offer tunability with respect to sensor dimension and physical properties, thereby enabling novel biological interfacing opportunities and extreme miniaturization. Here we provide an integrated overview of refractometric biosensing with nanoplasmonic devices and highlight some recent examples of nanoplasmonic sensors capable of unique functions that are difficult to accomplish with conventional SPR. For example, since the local field strength and spatial distribution can be readily tuned by varying the shape and arrangement of nanostructures, biomolecular interactions can be controlled to occur in regions of high field strength. This may improve signal-to-noise and also enable sensing a small number of molecules. Furthermore, the nanoscale plasmonic sensor elements may, in combination with nanofabrication and materials-selective surface-modifications, make it possible to merge affinity biosensing with nanofluidic liquid handling.

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Development of a mass-producible on-chip plasmonic nanohole array biosensor

Cited by 66 publications

References 48 publications

High‐Performance Plasmonic Sensors Based on Two‐Dimensional Ag Nanowell Crystals

High‐Performance Plasmonic Sensors Based on Two‐Dimensional Ag Nanowell Crystals

Tuning the 3D plasmon field of nanohole arrays

Promises and challenges of nanoplasmonic devices for refractometric biosensing

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