Promises and challenges of nanoplasmonic devices for refractometric biosensing

Dahlin, Andreas; Wittenberg, Nathan J.; Höök, Fredrik; Oh, Sang Hyun

doi:10.1515/nanoph-2012-0026

Cited by 88 publications

(76 citation statements)

References 138 publications

(189 reference statements)

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“…While our sensitivity and FOM calculations are consistent with literature and comparable to other plasmonic sensors 6,27,42 , further optimization is desirable and possible 58 . In our case, the buried surface of the sensor is still an as-deposited rough metal film (in contrast to the ultrasmooth sensing surface), which could account for a loss of sensitivity ( i.e.…”

Section: Resultssupporting

confidence: 85%

Polarization interferometry for real-time spectroscopic plasmonic sensing

et al. 2015

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We present quantitative, spectroscopic polarization interferometry phase measurements on plasmonic surfaces for sensing applications. By adding a liquid crystal variable wave plate in our beam path, we are able to measure phase shifts due to small refractive index changes on the sensor surface. By scanning in a quick sequence, our technique is extended to demonstrate real-time measurements. While this optical technique is applicable to different sensor geometries — e.g., nanoparticles, nanogratings, or nanoapertures — the plasmonic sensors we use here consist of an ultrasmooth gold layer with buried linear gratings. Using these devices and our phase measurement technique, we calculate a figure of merit that shows improvement over measuring only surface plasmon resonance shifts from a reflected intensity spectrum. To demonstrate the general-purpose versatility of our phase-resolved measurements, we also show numerical simulations with another common device architecture: periodic plasmonic slits. Since our technique inherently measures both the intensity and phase of the reflected or transmitted light simultaneously, quantitative sensor device characterization is possible.

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Section: Resultssupporting

confidence: 85%

Polarization interferometry for real-time spectroscopic plasmonic sensing

et al. 2015

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“…The physicochemical properties of nanomaterials influenced by protein corona include surface properties, aggregation properties and hydrodynamic size charge; in the meantime, the adhered proteins can endure conformational alternation, functionality changes, unmasking of new epitopes and alternations in avidity and affinity effects (Cedervall et al, 2007; Luyts et al, 2013; Nel et al, 2009). In contrast to using centrifugation, a conventional method that likely disturbs protein–NP complexes, a number of methodologies, including size-exclusion chromatography gel filtration, ITC, surface plasmon resonance (SPR), have been proposed for measuring dynamic and equilibrium parameters of the protein–NP interactions and estimating the potential of NP-associated risks (Cedervall et al, 2007; Dahlin et al, 2013). …”

Section: Characterization Of Nanomaterialsmentioning

confidence: 99%

Techniques for physicochemical characterization of nanomaterials

Lin

Wang

et al. 2014

Biotechnology Advances

543

297

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Advances in nanotechnology have opened up a new era of diagnosis, prevention and treatment of diseases and traumatic injuries. Nanomaterials, including those with potential for clinical applications, possess novel physicochemical properties that have an impact on their physiological interactions, from the molecular level to the systemic level. There is a lack of standardized methodologies or regulatory protocols for detection or characterization of nanomaterials. This review summarizes the techniques that are commonly used to study the size, shape, surface properties, composition, purity and stability of nanomaterials, along with their advantages and disadvantages. At present there are no FDA guidelines that have been developed specifically for nanomaterial based formulations for diagnostic or therapeutic use. There is an urgent need for standardized protocols and procedures for the characterization of nanoparticles, especially those that are intended for use as theranostics.

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“…[ 20,35 ] (Around one for the HEHB mode, which is higher than for the corresponding structure with a single Au fi lm. [ 4 ] For instance, one can operate in fl ow-through confi guration [ 16 ] and direct binding to the interior of the pores. [ 43 ] Thus, from a performance point of view, the MIM nanopores seem suitable although not superior for refractometric sensing applications.…”

Section: Refractive Index Sensingmentioning

confidence: 99%

Plasmonic Nanopores in Metal‐Insulator‐Metal Films

Dahlin

Mapar

Xiong

et al. 2014

Advanced Optical Materials

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In comparison with structures containing nanoparticles, relatively little effort has been spent on developing void-based structures, although many studies have looked at the optical properties of nanoholes in thin metal fi lms since the discovery of "extraordinary" transmission. [ 6 ] The optical properties of individual nanoholes and arrays thereof are now fairly well understood, [ 7 ] especially for the case of thicker (typically hundreds of nm) metal fi lms, where each interface supports its own surface plasmon polariton (SPP). Nanohole arrays in thinner fi lms (typically ∼50 nm or less), where the individual SPPs hybridize into two new modes, [8][9][10] are now also fairly well studied. [11][12][13] Due to their unique geometry, solid state nanopores in general [ 14 ] and plasmonic nanopores in particular [ 15,16 ] have proven valuable in several unique applications. For instance, since a continuous metal fi lm can operate as an electrode, additional sensing techniques can easily be implemented. [ 17,18 ] However, fabrication and optical characterization of more advanced nanopore-based structures such as apertures penetrating several fi lms is scarce. In a few cases holes continue into a dielectric supporting fi lm. [ 16,19,20 ] For the case of metal-insulator-metal (MIM) fi lms, structures with high void fractions and relatively large apertures have been fabricated [ 21,22 ] and evaluated as negative refractive index (RI) metamaterials in the near infrared. [ 21,23,24 ] Overall, the concept of MIM thin fi lms is interesting due to the appearance of new SPP modes and the possibility to utilize such modes, e.g., in waveguides. [25][26][27] However, to date nobody has presented apertures in MIM fi lms that have even a single of the following three properties: Connecting two compartments, small diameters (on the order of ∼100 nm or less) and a low (tens of percent) void fraction. As a consequence, the optical response of such structures has only been theoretically estimated [28][29][30] and there are no experimental studies on SPP excitation by nanopore arrays in MIM fi lms.In this work we show for the fi rst time fabrication of arrays of very small (down to at least 50 nm) pores penetrating suspended MIM fi lms and connecting two reservoirs (without representing a total void fraction of more than ∼10%). The dispersions and fi elds for the SPP modes of the system are solved for by extending a theoretical formalism we recently introduced. [ 31 ] With emphasis on the hybridization of the bonding mode surface plasmons, we demonstrate how the nanopore arrays can be used to excite SPP modes in the MIM structures using visible A novel type of plasmonic nanopore array in a metal-insulator-metal thin fi lm is presented. The optical properties of this structure are described using a generic theoretical framework for surface waves in a coupled multilayer system. The characteristic spacing (short-range order) of the pores enables grating-type coupling to hybridized surface plasmons, with stronger coupling to some modes tha...

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Promises and challenges of nanoplasmonic devices for refractometric biosensing

Cited by 88 publications

References 138 publications

Polarization interferometry for real-time spectroscopic plasmonic sensing

Polarization interferometry for real-time spectroscopic plasmonic sensing

Techniques for physicochemical characterization of nanomaterials

Plasmonic Nanopores in Metal‐Insulator‐Metal Films

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