Development of a green stability-indicating HPLC–DAD method for the determination of donepezil hydrochloride in the presence of its related substance and degradation products

Korany, Mohamed A.; Mahgoub, Hoda; Haggag, Rim S.; Ragab, Marwa A.A.; Elmallah, Osama A.

doi:10.1080/10826076.2017.1386672

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…12). [29][30][31][32] After comparing the eco-score values of other reported methods [11][12][13][14] with the proposed methods, it declares that the proposed methods are ecologically friendly. 33…”

Section: Evaluation Of Greenness Proposed Methodsmentioning

confidence: 99%

A Green Eco-friendly Analytical Method Development, Validation, and Stress Degradation Studies of Favipiravir in Bulk and Different Tablet Dosages Form by UV-spectrophotometric and RP-HPLC Methods with their Comparison by Using ANOVA and in-vitro Dissolution Studies

Chakraborty

Mondal

2023

Int J. Pharm. Investigation

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Favipiravir is an antiviral drug with significant and widespread antiviral action. Favipiravir was crucial in the contest against the COVID-19 pandemic because of how well it treated the SARS-CoV-2 virus. It is well known that contemporary pharmaceutical analysis establishes green, stability-indicating analytical procedures. The current study aimed to develop and assess UV-spectrophotometric (zero order, first order, area under the curve) and RP-HPLC methods for estimating favipiravir in its pharmaceutical dose form, comparing them using ANOVA and an in-vitro dissolution analysis. A green solvents composition of methanol, ethanol, and water (25:35:40 v/v/v) is used for analysis as a mobile phase and diluent. Method A is a simple zero-order spectrophotometric method for determining favipiravir at 236 nm, and the correlation coefficient in the linearity study was found to be 0.9962, LOD, and LOQ are 0.18 and 0.55 μg/mL. Method B is a first-order spectrophotometric method for determining favipiravir at 227 nm, and the correlation coefficient in the linearity study was found to be 0.9964, LOD, and LOQ are 0.64 and 1.96 μg/mL. Method C is an area under the curve spectrophotometric method for determining favipiravir at 230 to 243 nm, and the correlation coefficient in the linearity study was found to be 0.9986, LOD, and LOQ are 0.32 and 0.96 μg/mL. Method D is the RP-HPLC method for the determination of favipiravir at the retention time of 7.216 min, a flow rate of 0.80 mL/min, column temperature of 25°C, at 236 nm, Isocratic mode, and the correlation coefficient in the linearity study was found to be 0.9996, LOD, and LOQ are 0.52 and 1.56 μg/mL. All developed methods demonstrated good repeatability and recovery with %RSD < 2. The proposed established methods were assessed using one-way ANOVA. It was revealed that the F calculated value was lower than the F tabulated value, with no discernible variation in the assay results. Studies on stress degradation show that oxidation and acid degradation mostly impact favipiravir solutions. The Analytical Eco-scale verified that these methods are the greenest and most environmentally friendly, enabling the suggested approach to use an effective green analytical methodology to measure favipiravir extensively. Phosphate buffer (pH 6.4) was the best dissolution medium after analysis of the favipiravir dissolution study in several dissolution media.

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Section: Evaluation Of Greenness Proposed Methodsmentioning

confidence: 99%

A Green Eco-friendly Analytical Method Development, Validation, and Stress Degradation Studies of Favipiravir in Bulk and Different Tablet Dosages Form by UV-spectrophotometric and RP-HPLC Methods with their Comparison by Using ANOVA and in-vitro Dissolution Studies

Chakraborty

Mondal

2023

Int J. Pharm. Investigation

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“…All four regions will be filled green if they meet the requirements of green analytical chemistry. 45,47 The following are the criteria that render a method "less green": (1) A chemical used in the method is listed as a Persistent, bio accumulative, toxic (PBT) one, as defined by the Toxic Release Inventory (TRI) of the U.S. Environmental Protection Agency (EPA). (2) A chemical used in the method is listed on the TRI or one of the U.S. Resource Conservation and Recovery Act (RCRA)'s D, F, P, or U hazardous waste lists.…”

Section: Methods Validationmentioning

confidence: 99%

A Highly Sensitive Disposable In-House Screen-Printed Electrodes for Determination of 3,5-di-tert-butyl-4-hydroxybenzoic Acid Aided by Essential Green Chemistry Tools: Application in Nile River Samples and Human Urine

Zamzam

Hendawy

Abdel-Raoof

et al. 2021

J. Electrochem. Soc.

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A green voltammetric method of analysis is proposed for the electrochemical determination of 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHTCOOH); the major metabolite of the extensively consumed antioxidant, butylated hydroxytoluene (BHT). Environmental contamination by BHTCOOH is unavoidable owing to recurrence human exposure for these chemicals so (BHTCOOH) was detected in human urine and Nile River water samples. BHTCOOH is investigated by applying square-wave voltammetry (SWV) at two in-house fabricated screen-printed electrodes (SPE); Screen-Printed Graphite Electrode (SPGE) and Graphene-Modified Screen-Printed Graphite Electrode (GM-SPGE). Cyclic voltammetric analysis is used to optimize the voltammetric conditions. BHTCOOH oxidation on the surface of the electrodes is found to be irreversible and diffusion controlled. Using our fabricated SPEs, a linearity range of 4.88–21.62 and 0.12–1.31 μg ml−1 with minimum detectability levels of 1.06 and 0.03 μg ml−1 are reached at the surface of the SPGE and GM-SPGE, respectively. Moreover, the greenness of the method is inspected and found to be “excellent,” owing to the use of limited amounts of less hazardous chemicals and hence reduced waste production. The developed method is then successfully applied on urine and Nile-River samples; being the major source of water in Egypt, thereby allow for an adequate assessment of risks to human health and safety.

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UV-spectrophotometry versus HPLC–PDA for dual-drug dissolution profiling: which technique provides a closer step towards green biowaiver concept? Novel application on the recent FDA-approved mixture Aleve pm

et al. 2018

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Development of a green stability-indicating HPLC–DAD method for the determination of donepezil hydrochloride in the presence of its related substance and degradation products

Cited by 8 publications

References 19 publications

A Green Eco-friendly Analytical Method Development, Validation, and Stress Degradation Studies of Favipiravir in Bulk and Different Tablet Dosages Form by UV-spectrophotometric and RP-HPLC Methods with their Comparison by Using ANOVA and in-vitro Dissolution Studies

A Green Eco-friendly Analytical Method Development, Validation, and Stress Degradation Studies of Favipiravir in Bulk and Different Tablet Dosages Form by UV-spectrophotometric and RP-HPLC Methods with their Comparison by Using ANOVA and in-vitro Dissolution Studies

A Highly Sensitive Disposable In-House Screen-Printed Electrodes for Determination of 3,5-di-tert-butyl-4-hydroxybenzoic Acid Aided by Essential Green Chemistry Tools: Application in Nile River Samples and Human Urine

UV-spectrophotometry versus HPLC–PDA for dual-drug dissolution profiling: which technique provides a closer step towards green biowaiver concept? Novel application on the recent FDA-approved mixture Aleve pm

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