Development of a Cigarette Tobacco Filler Standard Reference Material

Abstract

A new tobacco filler Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST) in September 2016 with certified and reference mass fraction values for nicotine, N-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and volatiles. The constituents have been determined by multiple analytical methods with measurements at NIST and at the Centers for Disease Control and Prevention, and with confirmatory measurements by commercial laboratories. This effort highlights the development of the first SRM for reduced nicotine and reduced tobacco-specific nitrosamines with certified values for composition.

What is novel about certified reference materials?

“…Another first-time CRM matrix, cigarette tobacco filler, was introduced by Sander et al [5]. SRM 3222 Cigarette Tobacco Filler has certified values assigned for nicotine, two tobacco-specific nitrosamines [N-nitrosonornicotine (NNN) and 4-(methylnitrosomino)-1-(3-pridyl)-1-butanone (NNK)].…”

Mechanistic Insight into a Novel Ultrasensitive Nicotine Assay Base on High-Efficiency Quenching of Gold Nanocluster Cathodic Electrochemiluminescence

“…In addition, the rapid metabolism of nicotine renders the monitoring of nicotine concentrations in human fluids a great challenge. To date, different techniques, such as fluorescence, surface-enhanced Raman spectroscopy, electrochemistry, capillary electrophoresis (CE), and high-performance liquid chromatography (HPLC), have been used for nicotine assays. ,− HPLC is the most commonly used technique for the quantitative analysis of nicotine in real samples. However, the above methods may have several limitations such as the involvement of complex pretreatment procedures and high-potential, expensive instrumentation, and requirement of a skilled operator. , Thus, development of a convenient, efficient, cost-effective, fast-response, and highly sensitive method for nicotine determination is extremely urgent.…”