Simultaneous determination of multiple components in cigarettes by mechanochemical extraction and direct analysis in real time mass spectrometry in minutes

Jiang, Qing; Dai, Diya; Li, Hongli; Chen, David D. Y.

doi:10.1016/j.aca.2019.01.024

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Cigarette smoke is a highly complex and dynamically changing mixture because the burning of tobacco could lead to many chemical reactions. Thousands of compounds have been identified in cigarette smoke, and some of which are highly toxic and carcinogenic . MSS is directly inhaled when a person smokes and can be divided into gas-phase and particulate-phase substances .…”

Section: Resultsmentioning

confidence: 99%

“…Thousands of compounds have been identified in cigarette smoke, and some of which are highly toxic and carcinogenic. 34 MSS is directly inhaled when a person smokes and can be divided into gas-phase and particulate-phase substances. 35 With the increase in combustion time and puff number, the chemical signals of gaseous MSS in different puffs can be different.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Geng

Zhao

et al. 2021

Anal. Chem.

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Ambient ionization mass spectrometry (AIMS) is simple to operate for analytes adsorbed on the surface of various shaped probes. However, gaseous substances or liquids that are easy to evaporate, diffuse, and escape in the atmosphere are harder to capture. In this work, a Teeshaped sample introduction device coupled with direct analysis in real time mass spectrometry (DART-MS) is developed. The Tee-shaped device is placed between the DART ion source and the MS inlet with a heated sample transfer tube. Gaseous samples from either a Tedlar sampling bag or liquids evaporated from a graduated syringe were tested. The Tee-shaped device was used for several volatile organic compounds with a wide range of boiling points, and detection limits of ng/mL to fg/mL were obtained. To test the device for real-life samples, puff-by-puff analysis of a complex gaseous mainstream smoke was performed. Individual puffs can be analyzed rapidly, and there is no cross contamination between consecutive puffs. The dynamic changes of chemical components among different puffs for different types of cigarettes can be observed. This work provides a universal Tee-shaped sampling device to enhance AIMS for the analysis of volatile compounds and gases, which is adapted to different sampling modules applicable for various forms of samples. The device enables direct exploration of chemical components in complex gaseous samples without tedious sample preparation and time-consuming LC or GC separation.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Geng

Zhao

et al. 2021

Anal. Chem.

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“…Posteriorly, PAHs and TSNAs were simultaneously analyzed in smoke using online GPC-GC-MS/MS (Luo et al 2016). Multiple component analysis of different tobacco products was also performed using LC-MS/MS, UHPLC-MS/MS and by direct analysis in real-time mass spectrometry (DART-MS) (Wang et al, 2017;Wang et al, 2019;Jiang, Dai, Li & Chen, 2019), with the advantage of reducing analysis time. The present study examined the main papers that developed or improved analytical methods for identification and quantification of priority compounds in different tobacco products, and can contribute to future research with this objective.…”

Section: Discussionmentioning

confidence: 99%

Trends in Analytical Methods for Analysis of Tobacco Products: An Overview

Costa

Vasconcelos²,

Moura³

et al. 2022

R. Eletr. TECCEN

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Abstract. Currently, due to the strong trends in policies to reduce smoking, several concerns related to quality control and regulation of tobacco products have been raised, as a great variety of products are available to consumers in the market. Considering that development of robust and selective analytical methods for tobacco and derivative products has been an important and necessary task over the years, however laborious, due to the complexity of the matrices. This work presents an overview of advances, innovation, and trends in analytical methods, focused on the chromatographic analysis of nicotine, tobacco-specific nitrosamines (TSNAs), humectants, pesticides, polycyclic aromatic hydrocarbons (PAHs) and sugars in different tobacco products. Gas chromatography (GC) coupled with different detectors is widely used to analyze nicotine, humectants and TSNAs in tobacco leaves and derivative products, while liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been frequently used to analyze TSNAs in mainstream cigarette smoke and smokeless tobacco products. Pesticides were mainly analyzed in tobacco using GC or LC coupled with mass detector (MS), while PAHs and sugars were generally analyzed in tobacco and smoke using LC-MS and GC-MS techniques, respectively. In addition to already established methods and despite the lack of a worldwide standardization of methods, significant efforts have been made to develop analytical procedures for a wide variety of tobacco products, with a broad range of innovative chromatographic methods available. In this sense, a potential trend is the possibility of simultaneous determination of multiple components aiming to reduce the analysis time. The present study examined the main works that developed or improved analytical methods for identifying and quantifying priority compounds in different tobacco matrices and aims to contribute to future research with this objective, in addition, to promoting standardization of technical terms used in this analytical area. It is noteworthy that some of the methods mentioned here have not been validated and further studies are needed in order to obtain reproducible analytical methods for regulatory purposes. Keywords: chromatography analyses; tobacco leaves; cigarette; cigarette smoke; smokeless tobacco products.

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Characterization of ginsenoside structural isomers from mixtures using in situ methylation with direct analysis in real-time ionization tandem mass spectrometry

et al. 2022

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Simultaneous determination of multiple components in cigarettes by mechanochemical extraction and direct analysis in real time mass spectrometry in minutes

Cited by 3 publications

References 34 publications

Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Tee-Shaped Sample Introduction Device Coupled with Direct Analysis in Real-Time Mass Spectrometry for Gaseous Analytes

Trends in Analytical Methods for Analysis of Tobacco Products: An Overview

Characterization of ginsenoside structural isomers from mixtures using in situ methylation with direct analysis in real-time ionization tandem mass spectrometry

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