Development of a bioactive glass-polymer composite for wound healing applications

Moura, Diana; Souza, Marina Trevelin; Liverani, Liliana; Rella, G.; Luz, Gisela M.; Mano, João F.; Boccaccını, Aldo R.

doi:10.1016/j.msec.2017.03.037

Cited by 88 publications

(61 citation statements)

References 68 publications

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“…BGNs can be dispersed in the polymer solution for electrospinning to construct fibrous composite scaffolds in which BGNs serve as suitable carriers for the delivery of therapeutic ions to impart biological functions to the fibers [22,38,39]. The incorporation of sol-gel borate bioactive glass particles [40] and dual ion doped silicate BGNs [41] in PCL electrospun fibers using benign solvents has been already reported in the literature. Differently to the previous studies, in this work, B and Co co-doped BGNs were embedded into PCL dissolved in acetic acid to fabricate composite fiber mats with dual ion delivery for angiogenesis promotion during tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Chen

Galusková²,

Kaňková³

et al. 2020

Materials

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Vascularization is necessary in tissue engineering to keep adequate blood supply in order to maintain the survival and growth of new tissue. The synergy of biologically active ions with multi-target activity may lead to superior angiogenesis promotion in comparison to single-target approaches but it has been rarely investigated. In this study, polycaprolactone (PCL) fiber mats embedded with B and Co co-doped bioactive glass nanoparticles (BCo.BGNs) were fabricated as a tissue regeneration scaffold designed for promoting angiogenesis. BCo.NBGs were successfully prepared with well-defined spherical shape using a sol-gel method. The PCL fiber mats embedding co-doped bioactive glass nanoparticles were fabricated by electrospinning using benign solvents. The Young’s moduli of the nanoparticle containing PCL fiber mats were similar to those of the neat fiber mats and suitable for scaffolds utilized in soft tissue repair approaches. The mats also showed non-cytotoxicity to ST-2 cells. PCL fiber mats containing BCo.BGNs with a relatively high content of B and Co promoted the secretion of vascular endothelial growth factor to a greater extent than PCL fiber mats with a relatively low B and Co contents, which demonstrates the potential of dual ion release (B and Co) from bioactive glasses to enhance angiogenesis in soft tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Chen

Galusková²,

Kaňková³

et al. 2020

Materials

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“…2 The wound healing process is extremely complex and is regulated by interactions among several factors, all of which promote the reconstruction of a skin barrier. 3 The reconstruction process is impaired by events such as hematoma, overreactive inflammation (reactive oxygen species) and limited angiogenesis. 4 N-acetylcysteine (NAC) is an antioxidant approved by the Food and Drug Administration for clinical use in the treatment of oxidative stress-related diseases such as diabetic ulcers.…”

Section: Introductionmentioning

confidence: 99%

<p>Multi-Layered Polyamide/Collagen Scaffolds with Topical Sustained Release of N-Acetylcysteine for Promoting Wound Healing</p>

Hou¹,

Chen²,

Zhou³

et al. 2020

IJN

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Background: Impaired wound healing might be associated with many issues, especially overactive of reactive oxygen species (ROS), deficiency of blood vessels and immature of epidermis. N-acetylcysteine (NAC), as an antioxidant, could solve these problems by inhibiting overreactive of ROS, promoting revascularization and accelerating re-epithelialization. How to deliver NAC in situ with a controllable releasing speed still remain a challenge. Materials and Methods: In this study, we combined collagen (Col) with N-acetylcysteine to perform the characteristics of sustained release and chemically crosslinked Col/NAC composite with polyamide (PA) nanofibers to enhance the mechanical property of collagen and fabricated this multi-layered scaffold (PA-Col/NAC scaffold). The physical properties of the scaffolds such as surface characteristics, water absorption and tensile modulus were tested. Meanwhile, the ability to promote wound healing in vitro and in vivo were investigated. Results: These scaffolds were porous and performed great water absorption. The PA-Col /NAC scaffold could sustainably release NAC for at least 14 days. After cell implantation, PA-Col/NAC scaffold showed better cell proliferation and cell migration than the other groups. In vivo, PA-Col/NAC scaffolds could promote wound healing best among all the groups. Conclusion: The multi-layered scaffolds could obviously accelerate the process of wound healing and exert better and prolonged effects.

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“…Many biomaterials such as alginate, cellulose, chitosan, collagen, and poly (ε-caprolactone) are promising for biomedical applications [1]. Medicinal plant extracts, spices, and essential oils have also been used as biologically active agents for personal care, pharmaceuticals, and foodprocessing applications [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

Horzum

Kinali

2019

Cumhuriyet Science Journal

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Polymeric electrospun fibers present well-design scaffolds for wound healing applications. Here, the fabrication of biobased polyurethane (PU) blend fibers containing curcumin (Cur) was reported. Not only polymer concentration but also curcumin concentration affects the morphology, diameter, and contact angle values of the fibers. Morphological investigations revealed that the diameter and hydrophilicity of the PU fibers increased upon addition of curcumin. Effect of process parameters (applied voltage, flow rate, and tipto-collector distance) on the average diameter and the hydrophilicity of the PU and PU/Cur fibers were examined. Optimum conditions to obtain uniform and bead-free PU/Cur fibers were determined as 12.5 kV, 1 mL/h, and 17 cm. This study demonstrates that the electrospinning process provides a simple way of obtaining bioactive agent loaded fibrous scaffolds, as well as contributing to a better understanding of the effect of process variables in the fabrication of PU/Cur blend fibers for wound healing applications.

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Development of a bioactive glass-polymer composite for wound healing applications

Cited by 88 publications

References 68 publications

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

<p>Multi-Layered Polyamide/Collagen Scaffolds with Topical Sustained Release of N-Acetylcysteine for Promoting Wound Healing</p>

Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

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