Development of a bifunctional nanobiosensor for screening and detection of chemokine ligand in colorectal cancer cell line

Chung, Saeromi; Chandra, Pranjal; Koo, Jaseok Peter; Shim, Yoon‐Bo

doi:10.1016/j.bios.2017.09.031

Cited by 43 publications

(14 citation statements)

References 22 publications

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“… 38 This technique permits one to monitor the evolution of the electrical circuit created on the sensor surface, which is modified by the interaction between the antigen–antibody complex. Examples of impedimetric immunosensor for diagnosis purpose has been reported for the neuroinflammatory biomarkers; cytokines, 93 chemokines, 94 CAMs, 95 and MMPs, 96 as well as aptabeacons for IFN-γ cytokine analysis by Liu et al 97 …”

Section: Future Oportunities For the Integration Of Biosensors In Bbb-ocmentioning

confidence: 99%

Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

et al. 2022

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Over the most recent decades, the development of new biological platforms to study disease progression and drug efficacy has been of great interest due to the high increase in the rate of neurodegenerative diseases (NDDs). Therefore, blood–brain barrier (BBB) as an organ-on-a-chip (OoC) platform to mimic brain-barrier performance could offer a deeper understanding of NDDs as well as a very valuable tool for drug permeability testing for new treatments. A very attractive improvement of BBB-oC technology is the integration of detection systems to provide continuous monitoring of biomarkers in real time and a fully automated analysis of drug permeably, rendering more efficient platforms for commercialization. In this Perspective, an overview of the main BBB-oC configurations is introduced and a critical vision of the BBB-oC platforms integrating electronic read out systems is detailed, indicating the strengths and weaknesses of current devices, proposing the great potential for biosensors integration in BBB-oC. In this direction, we name potential biomarkers to monitor the evolution of NDDs related to the BBB and/or drug cytotoxicity using biosensor technology in BBB-oC.

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Section: Future Oportunities For the Integration Of Biosensors In Bbb-ocmentioning

confidence: 99%

Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

et al. 2022

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“…In another study, AuNPs functionalized with thiol-modified receptor for glucose biosensing has been developed to monitor the glucose level of diabetic patients (Spampinato et al 2016). In addition, functionalized AuNPs assisted strategies are constantly adding the qualities to various biosensors in terms of sensitivity, selectivity, limit of detection, dynamic range and compatible with numerous analytes including drugs, neurotransmitters, heavy metal ions, bacterial/cancer cells, and other metabolically active molecules (Zhu et al 2012c;Chandra et al 2011b;Kashish et al 2017;Chung et al 2018;Akhtar et al 2018;Baranwal and Chandra 2018).…”

Section: Sensors and Biosensorsmentioning

confidence: 99%

Gold nanoparticle surface engineering strategies and their applications in biomedicine and diagnostics

et al. 2019

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Gold nanoparticles (AuNPs) have found a wide range of biomedical and environmental monitoring applications (viz. drug delivery, diagnostics, biosensing, bio-imaging, theranostics, and hazardous chemical sensing) due to their excellent optoelectronic and enhanced physico-chemical properties. The modulation of these properties is done by functionalizing them with the synthesized AuNPs with polymers, surfactants, ligands, drugs, proteins, peptides, or oligonucleotides for attaining the target specificity, selectivity and sensitivity for their various applications in diagnostics, prognostics, and therapeutics. This review intends to highlight the contribution of such AuNPs in state-of-the-art ventures of diverse biomedical applications. Therefore, a brief discussion on the synthesis of AuNPs has been summarized prior to comprehensive detailing of their surface modification strategies and the applications. Here in, we have discussed various ways of AuNPs functionalization including thiol, phosphene, amine, polymer and silica mediated passivation strategies. Thereafter, the implications of these passivated AuNPs in sensing, surface-enhanced Raman spectroscopy (SERS), bioimaging, drug delivery, and theranostics have been extensively discussed with the a number of illustrations.

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“…A bifunctional electrochemical nanobiosensor was developed for the screening and detection of chemokine (C-X-C motif) ligand 5 (CXCL5) with a natural chemokine receptor molecule (CXCR2) [147]. CXCL5 is a member of a subset of CXC chemokines that regulates cellular functions such as neutrophil trafficking and tumor angiogenesis.…”

Section: Electrochemical Biosensing Of Protein Biomarkers Of Crcmentioning

confidence: 99%

“…The results showed that the R ct value increased only with increasing concentrations of CXCL5 in the sample, demonstrating the specificity of the biosensor. Another strategy was based on the union of CXCL5 with hydrazine (hyd) (CXCL5 hyd ), which acts as the electrocatalyst for the catalytic reduction of hydrogen peroxide [147,149]. The analytical performance of such a biosensor was tested by amperometry at -450 mV versus Ag/AgCl, having a linear response from 0.1 to 10 ng mL −1 , with an LOD of 0.078 ng mL −1 .…”

Section: Electrochemical Biosensing Of Protein Biomarkers Of Crcmentioning

confidence: 99%

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

et al. 2020

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The accurate determination of specific tumor markers associated with cancer with non-invasive or minimally invasive procedures is the most promising approach to improve the long-term survival of cancer patients and fight against the high incidence and mortality of this disease. Quantification of biomarkers at different stages of the disease can lead to an appropriate and instantaneous therapeutic action. In this context, the determination of biomarkers by electrochemical biosensors is at the forefront of cancer diagnosis research because of their unique features such as their versatility, fast response, accurate quantification, and amenability for multiplexing and miniaturization. In this review, after briefly discussing the relevant aspects and current challenges in the determination of colorectal tumor markers, it will critically summarize the development of electrochemical biosensors to date to this aim, highlighting the enormous potential of these devices to be incorporated into the clinical practice. Finally, it will focus on the remaining challenges and opportunities to bring electrochemical biosensors to the point-of-care testing.

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Development of a bifunctional nanobiosensor for screening and detection of chemokine ligand in colorectal cancer cell line

Cited by 43 publications

References 22 publications

Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

Gold nanoparticle surface engineering strategies and their applications in biomedicine and diagnostics

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

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