This study evaluated an expressive arts intervention program (BColorful Life^) for adolescents with addicted parents and parents with addiction in Hong Kong. Different evaluation strategies were employed. Objective outcome evaluation adopting a one group pretest-posttest design showed positive changes in adolescents' (N = 43) beliefs about addiction. Both adolescents' and parents' (N = 21) psychosocial competencies were enhanced postintervention. Subjective outcome evaluation from both adolescent (N = 47) and parent (N = 22) groups showed positive perceptions of the program content, implementers, and achievement of program objectives. Findings provided preliminary evidence to support and yielded practical implications for the adoption of the multi-addiction syndrome model, positive youth development, and expressive arts approaches in the development of interventions for high-risk adolescents and addictive parents.Keywords Multi-addiction prevention . Expressive arts . Intervention . Addicted parents . AdolescentsIn the new edition of Diagnostic and Statistical Manual, 5th edition (DSM-5; American Psychiatric Association 2013), a revised category BSubstance-Related and Addictive Disorders^was proposed. This new category combines two general types of addiction disorders, i.e., substance-related addiction (e.g., drug and alcohol) and behavioral Int