Development, Fabrication, and Characterization of Composite Polycaprolactone Membranes Reinforced with TiO2 Nanoparticles

Ángel-Sánchez, Karina Del; Borbolla-Torres, César I; Palacios-Pineda, Luis Manuel; Ulloa-Castillo, Nicolás A.; Elı́as-Zúñiga, Alex

doi:10.3390/polym11121955

Cited by 17 publications

(14 citation statements)

References 27 publications

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“…The above analysis does not exclude the presence of other oxygen-based radicals because the superoxide radical anion, O 2 − , the peroxy-type radicals (RCOO•) and O 2 − of organic-type adducts could be indistinguishable by the CW-EPR spectroscopy [52]. The role of oxidative stress in titanium dioxide-induced antimicrobial activity was confirmed by several previously published reports [24,25,41,53,54]. The promote photo-oxidation and photo-reduction processes, which can lead to ROS generation, were also observed for TOCs systems [14,18,55].…”

Section: Discussionmentioning

confidence: 69%

“…Moreover, work is underway on composite materials with appropriate antimicrobial activity, which are obtained by introducing an inorganic agent, such as ZnO and CuO, into the PCL matrix [40]. The use of the PCL/TiO 2 system is especially interesting in the production of composite fibers using the electrospinning method [41][42][43][44][45][46]. It was noticed that the addition of TiO 2 particles to PCL matrix influences the reduction of its water absorption and improves the mechanical properties (e.g., compressive strength) [41].…”

Section: Introductionmentioning

confidence: 99%

“…The use of the PCL/TiO 2 system is especially interesting in the production of composite fibers using the electrospinning method [41][42][43][44][45][46]. It was noticed that the addition of TiO 2 particles to PCL matrix influences the reduction of its water absorption and improves the mechanical properties (e.g., compressive strength) [41]. Moreover, Kiran et al, investigating the antimicrobial activity of PCL/TiO 2 coatings and irradiated by UV light produced on the titanium implants surface, exhibited improvement of their biological properties and antibacterial activity [42].…”

Section: Introductionmentioning

confidence: 99%

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The Composites of PCL and Tetranuclear Titanium(IV)-oxo Complexes as Materials Exhibiting the Photocatalytic and the Antimicrobial Activity

Kubiak

Radtke

Topolski

et al. 2021

IJMS

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Excessive misuse of antibiotics and antimicrobials has led to a spread of microorganisms resistant to most currently used agents. The resulting global threats has driven the search for new materials with optimal antimicrobial activity and their application in various areas of our lives. In our research, we focused on the formation of composite materials produced by the dispersion of titanium(IV)-oxo complexes (TOCs) in poly(ε-caprolactone) (PCL) matrix, which exhibit optimal antimicrobial activity. TOCs, of the general formula [Ti4O2(OiBu)10(O2CR')2] (R' = PhNH2 (1), C13H9 (2)) were synthesized as a result of the direct reaction of titanium(IV) isobutoxide and 4-aminobenzoic acid or 9-fluorenecarboxylic acid. The microcrystalline powders of (1) and (2), whose structures were confirmed by infrared (IR) and Raman spectroscopy, were dispersed in PCL matrixes. In this way, the composites PCL + nTOCs (n = 5 and 20 wt.%) were produced. The structure and physicochemical properties were determined on the basis of Raman microscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), electron paramagnetic resonance spectroscopy (EPR), and UV–Vis diffuse reflectance spectroscopy (DRS). The degree of TOCs distribution in the polymer matrix was monitored by scanning electron microscopy (SEM). The addition of TOCs micro grains into the PCL matrix only slightly changed the thermal and mechanical properties of the composite compared to the pure PCL. Among the investigated PCL + TOCs systems, promising antibacterial properties were confirmed for samples of PCL + n(2) (n = 5, 20 wt.%) composites, which simultaneously revealed the best photocatalytic activity in the visible range.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Composites of PCL and Tetranuclear Titanium(IV)-oxo Complexes as Materials Exhibiting the Photocatalytic and the Antimicrobial Activity

Kubiak

Radtke

Topolski

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…Gomes [ 60 ] produced more crystalline PCL fibers, reducing the acetic acid content, using 95:5 acetic acid:water ratios. The low volatility and low chemical affinity of acetic acid with the PCL’s hydrophobic chain lead to less aggressive solubilization, affecting crystal domains’ formation [ 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

et al. 2021

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Developing a biomimetic material to wound care is an emerging need for the healing process. Poly (ε-caprolactone) (PCL) is a polymer with the necessary dressing’s requirements often used in medicine. Their surface, physic-chemical and biological properties can be modified by adding bioactive compounds, such as andiroba seed oil (Carapa guianensis). This Amazonian natural plant has medicinal and pharmacological properties. For this purpose, PCL polymeric films incorporated with andiroba oil were investigated. The synthesis of hybrids materials was carried out in the solvent casting method. Thermal properties were evaluated using thermogravimetric analysis (TGA/DTGA) and differential scanning calorimetry (DSC). The solvent type on the surface and hydrophilicity of samples was studied using a scanning electron microscope (SEM). Additionally, contact angle measurements, functional groups analysis, fluid absorption capacity, and cell viability were performed. The results demonstrated the influences of andiroba oil under the morphology and thermal properties of the polymeric matrix; the hydrophilicity of the hybrid film obtained by acetic acid was reduced by 13%; the porosity decreased as the concentration of oil increased, but its higher thermal stability. The L929 cell line’s proliferation was observed in all materials, and it presented nontoxic nature. It was demonstrated the ability of PCL hybrid film as a matrix for cell growth. Then, the materials were proved potential candidates for biomedical applications.

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“…Wettability was determined using contact angle measurement. A typical droplet size in contact angle measurement on PCL ranges from 2-10 µl (59)(60)(61)(62)(63)(64)(65)(66)(67)(68), which would cover the whole surface of a 3D printed filament. Therefore, extruded PCL filaments were immersed in Milli-Q ® water and pictures were continuously taken while raising the filaments slowly from the water with DinoCapture Camera (AnMo Electronic Corporation, Taipei, Taiwan).…”

Section: Wettabilitymentioning

confidence: 99%

Biofabrication of development-inspired scaffolds for regeneration of the annulus fibrosus macro- and microarchitecture

Kluser

Sprecher

Alig

et al. 2021

Preprint

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Annulus fibrosus (AF) tissue engineering is a promising strategy for repairing the degenerated intervertebral disc (IVD) and a research area that could benefit from improved tissue models to drive translation. AF tissue is composed of concentric layers of aligned collagen bundles arranged in an angle-ply pattern, an architecture which is challenging to recapitulate with current scaffold design strategies. In response to this need, we developed a strategy to print 3D scaffolds that induce cell and tissue organization into oriented patterns mimicking the AF. Polycaprolactone (PCL) was printed in an angle-ply macroarchitecture possessing microscale aligned topographical cues. The topography was achieved by extrusion through custom-designed printer nozzles which were either round or possessing circumferential sinusoidal peaks. Whereas the round nozzle produced extruded filaments with a slight uniaxial texture, patterned nozzles with peak heights of 60 or 120 μm produced grooves, 10.87 ± 3.09 μm or 17.77 ± 4.91 μm wide, respectively. Bone marrow derived mesenchymal stem cells (BM-MSCs) cultured on the scaffolds for four weeks exhibited similar degrees of alignment within ± 10 ° of the printing direction and upregulation of outer AF markers (COL1, COL12, SFRP, MKX, MCAM, SCX and TAGLN), with no statistically significant differences as a function of topography. Interestingly, the grooves generated by the patterned nozzles induced longitudinal end-to-end alignment of cells, capturing the arrangement of cells during fibrillogenesis. In contrast, topography produced from the round nozzle induced a continuous web of elongated cells without end-to-end alignment. Extracellular collagen I, decorin and fibromodulin were detected in patterns closely following cellular organization. Taken together, we present a single-step biofabrication strategy to induce anisotropic cellular alignments in x-, y-, and z-space, with potential application as an in vitro model for studying AF tissue morphogenesis and growth.

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Development, Fabrication, and Characterization of Composite Polycaprolactone Membranes Reinforced with TiO2 Nanoparticles

Cited by 17 publications

References 27 publications

The Composites of PCL and Tetranuclear Titanium(IV)-oxo Complexes as Materials Exhibiting the Photocatalytic and the Antimicrobial Activity

The Composites of PCL and Tetranuclear Titanium(IV)-oxo Complexes as Materials Exhibiting the Photocatalytic and the Antimicrobial Activity

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

Biofabrication of development-inspired scaffolds for regeneration of the annulus fibrosus macro- and microarchitecture

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