PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

Abstract

Developing a biomimetic material to wound care is an emerging need for the healing process. Poly (ε-caprolactone) (PCL) is a polymer with the necessary dressing’s requirements often used in medicine. Their surface, physic-chemical and biological properties can be modified by adding bioactive compounds, such as andiroba seed oil (Carapa guianensis). This Amazonian natural plant has medicinal and pharmacological properties. For this purpose, PCL polymeric films incorporated with andiroba oil were investigated. The synthesis of hybrids materials was carried out in the solvent casting method. Thermal properties were evaluated using thermogravimetric analysis (TGA/DTGA) and differential scanning calorimetry (DSC). The solvent type on the surface and hydrophilicity of samples was studied using a scanning electron microscope (SEM). Additionally, contact angle measurements, functional groups analysis, fluid absorption capacity, and cell viability were performed. The results demonstrated the influences of andiroba oil under the morphology and thermal properties of the polymeric matrix; the hydrophilicity of the hybrid film obtained by acetic acid was reduced by 13%; the porosity decreased as the concentration of oil increased, but its higher thermal stability. The L929 cell line’s proliferation was observed in all materials, and it presented nontoxic nature. It was demonstrated the ability of PCL hybrid film as a matrix for cell growth. Then, the materials were proved potential candidates for biomedical applications.

Synthesis and Characterization of Natural Polymeric Membranes Composed of Chitosan, Green Banana Peel Extract and Andiroba Oil

“…Milk et al [ 20 ] found that the addition of oil to chitosan membranes provided a decrease in the contact angle. However, a similar study by Silva et al [ 22 ] found different results, demonstrating that the introduction of andiroba oil into the membrane composition confers greater hydrophobic power to the material.…”

Chitosan Membrane Containing Copaiba Oil (Copaifera spp.) for Skin Wound Treatment

“…Silva et al [ 45 ] observed that the addition of andiroba oil decreases the number and size of pores, as the concentration of oil in poly-based polymeric film (ε-caprolactone) (PCL), as well as no oil retention on the surface of the films, which may indicate a good interaction of the compound PCL/andiroba. However, the changes that occurred in the structure of chitosan with the incorporation of oils depending on the molecular structure of the polymer and its chemical interactions.…”

Precise Fabrication of Porous Microspheres by Iso-Density Emulsion Combined with Microfluidics

“…The results from the second heating were adopted to eliminate the thermal history [34]. The degree of crystallinity could be obtained by the following formula [35]:…”