Development and validation of a dissolution method for novel fixed dose combination of etodolac and propranolol hydrochloride tablets by RP-HPLC

Mohan, Akhila Maheswari; Dhayalamurthi, S.; Anandan, P; Saravanan, D.

doi:10.1556/achrom.23.2011.4.2

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2020

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“…Etodolac is chemically as 1, 8-Diethyl-1, 3, 4, 9-tetrahydropyrone (3, 4-b) indole -1-acetic acid. It is a racemic mixture of [+] S enantiomers and [-] R enantiomers 1 .Etodolac is belongs to pyranocarboxylic acid class of non-steroidal anti-inflammatory drug, developed in the 1970s 2 .It is used for rheumatoid arthritis and osteoarthritis, postoperative pain and inflammation 3 , and used as analgesic, anti-inflammatory agent, antipyretic and cyclooxygenase inhibitor. The mechanism of action of Etodolac is mainly prostaglandin synthetase enzyme inhibition.…”

Section: Introductionmentioning

confidence: 99%

Determination of Etodolac by Rp-HPLC Method

Bhamare¹,

Kamble²

2020

Int. Res. J. Pharm.

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A simple, rapid, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Etodolac was developed and validated according to ICH guidelines. The quantification of the drug was carried using photodiode array detector. RP-C18 column was used in isocratic mode, with 60:40 ratio of Acetonitrile: Methanol as a mobile phase. The flow rate was set to 1.0 ml/min. The UV detection was carried out at wavelength 226 nm wavelength was selected for analysis. The method was validated by performing recovery study.

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Section: Introductionmentioning

confidence: 99%