Determination of Etodolac by Rp-HPLC Method

Abstract

A simple, rapid, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Etodolac was developed and validated according to ICH guidelines. The quantification of the drug was carried using photodiode array detector. RP-C18 column was used in isocratic mode, with 60:40 ratio of Acetonitrile: Methanol as a mobile phase. The flow rate was set to 1.0 ml/min. The UV detection was carried out at wavelength 226 nm wavelength was selected for analysis. The method was validated by performing recovery study.