Development and Optimization of Piroxicam-loaded Solid Self-micro emulsifying Drug Delivery System

Pattewar, Seema; Kasture, Sanjay; Pande, Vishal; Patil, Deepak; Sharma, Shivani

doi:10.4172/pharmaceutical-sciences.1000364

Cited by 6 publications

(8 citation statements)

References 27 publications

(31 reference statements)

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“…6 and 7. Cremophor EL (polyoxyethylene-(35)-caster oil) is considered to be the liquid form of Cremophor RH40 (HLB, 14-16) yet with lower HLB value (12)(13)(14) due to less ethoxylation number. This has reflected on the area of miscibility as depicted by the ternary phase diagram ( fig.…”

Section: Fig 2: Ternary Phase Diagram For Miglyol 812/imwitor 988-crmentioning

confidence: 99%

“…Type II formulations are often referred to as SEDDS which comprise water-insoluble components; blends of glycerides and non-ionic surfactants with HLBs less than 12 such as; polysorbate 85 (Tween 85) or polyoxyethylene 25glyceryl trioleate (Tagat TO). Type III systems contain blends of glycerides (oils), hydrophilic surfactants with HLB>12 such as; Cremophor RH40 [10,11], Cremophor EL [12,13], Tween 80 [14,15], Tween 20 [14] or Tagat O2 [16] and/or hydrophilic co-solvents such as, ethanol, propylene glycol or polyethylene glycol. Type III formulations which include water-soluble components are referred to as self-micro-emulsifying systems (SMEDDS) as they can lead to the production of a microemulsion on dispersion in GI tract (particle size ≈ 50 nm).…”

Section: Introductionmentioning

confidence: 99%

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Role of Hydrophilic Surfactants in the Emulsification Mechanistics of Type Iii Self-Micro-Emulsifying Drug Delivery Systems (Smedds)

Hasan

2019

Int J App Pharm

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Objective: Evaluation of the self-emulsifying behaviour of type III lipid systems comprising mixed medium chain glycerides (Miglyol 812-Imwitor 988) and wide range of hydrophilic surfactants in an attempt to identify self-emulsifying microemulsion formulations, prevaricate the crystallization tendency of Cremophor RH40 in the pre-microemulsion concentrate, to shed some light on the mechanistic behavior of these systems after aqueous dispersion. Methods: Non-ionic surfactants with HLB in the range 14 to 16.5 are investigated amongst these are; Cremophor RH40, Cremophor EL, Crillet 4 (polysorbate 80), Crillet 1 (polysorbate 20) and Tagat O2. Optimum oil blends of Miglyol 812-Imwitor 988 and various non-ionic surfactant systems were verified using self-emulsification performance studies, oil droplet diameter measurements and dynamic equilibrium phase studies. Results: Oil blends of Miglyol 812 as an oil and Imwitor 988 as a cosurfactant were optimized for microemulsion systems at ratios of 1:1 in the case of Cremophor RH40 or EL, and at 2:3 in the case of Crillet 4 or Tagat O2. In order to obtain small droplet size and fast dispersion rate for type III lipid systems, hydrophilic surfactants with HLB values between 13 and 15 were found to be the optimum. Conclusion: Spontaneous micro-emulsification in type III lipid system was attributed to the “diffusion and stranding” theory. Yet, the formation of liquid crystalline phases as intermediate phases during dilution of the oil formulation with water appears to be quintessential for the mechanistics of emulsification regardless type of lipid class system.

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Section: Fig 2: Ternary Phase Diagram For Miglyol 812/imwitor 988-crmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Hydrophilic Surfactants in the Emulsification Mechanistics of Type Iii Self-Micro-Emulsifying Drug Delivery Systems (Smedds)

Hasan

2019

Int J App Pharm

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“…SNEDDS formulation's drug content has been detected with the use of UV Spectrophotometer assay, 0.4 milliliter (equal to 10 milligram PIR) from each prepared formulation has been diluted to 100 milliliters with methanol and mixed thoroughly. The resultant solutions have been evaluated at estimated λ max (16,18,19) .…”

Section: Determination Of Drug Contentmentioning

confidence: 99%

Formulation and Characterization of Piroxicam as Self-Nano Emulsifying Drug Delivery System

Salim¹,

Rajab²

2020

IJPS

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Piroxicam (PIR) is a nonsteroidal anti-inflammatory drug of oxicam category, used in gout, arthritis, as well as other inflammatory conditions (topically and orally). PIR is practically insoluble in water, therefore the aim is prepare and evaluate piroxicam as liquid self-nanoemulsifying drug delivery system to enhance its dispersibility and stability. The Dispersibilty and Stability study have been conducted in Oil, Surfactant and Co-surfactant for choosing the best materials to dissolve piroxicam. The pseudo ternary phase diagrams have been set at 1:1, 2:1, 3:1 as well as 4:1 ratio of surfactants and co-surfactants, also there are 4 formulations were prepared by using various concentrations of transcutol HP, cremophore EL and triacetin oil. All the constructed prepared formulas have been assessed for in vitro drug dissolution, thermodynamic stability, polydispersity index, robustness to dilution, particle size distribution, drug content, and the dispersibility and emulsification time.From the presented research concluded that the self-nanoemulsifying drug delivery system is the convenient method for improving Dispersibilty and Stability of piroxicam. Keywords: Pseudo-ternary phase diagram, Dissolution rate, SNEDDS, Piroxicam.

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“…Response surface diagram was constructed and those transparent formulations exhibiting no precipitation were studied further. The formulation was optimized using a response surface diagram produced using Design-Expert® software version 10 (Stat-Ease) [19] .…”

Section: Experimental Design For Smeddsmentioning

confidence: 99%

Fabrication and Characterization of Self-microemulsifying Mouth Dissolving Film for Effective Delivery of Piroxicam

Pattewar¹,

Pande²,

Patil³

et al. 2019

pharmaceutical-sciences

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Pattewar et al.: Self-microemulsifying Mouth Dissolving Film Self-microemulsifying drug delivery systems are widely used to address water-solubility issues of drug candidates, but with these systems, there is a chance of drug precipitation due to migration of the surfactant in the shell of capsule. Piroxicam is a class II drug that exhibits poor solubility and high permeability. Efforts were made to develop piroxicam self-microemusifying mouth dissolving fi lm using a polymer such as hydroxylpropyl methylcellulose as a fi lm-forming polymer and optimized using response surface methodology of Design-Expert® software version 10. A sublingual self-microemusifying mouth dissolving fi lm was prepared that disintegrated in 26 seconds. The in vitro drug release of self-microemusifying mouth dissolving fi lm was 98.04±0.016% in 5 min. The newly developed sublingual self-microemusifying mouth dissolving fi lm provided rapid absorption of piroxicam (t max ~2 h) and suitable for providing a rapid onset of analgesic action.

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Development and Optimization of Piroxicam-loaded Solid Self-micro emulsifying Drug Delivery System

Cited by 6 publications

References 27 publications

Role of Hydrophilic Surfactants in the Emulsification Mechanistics of Type Iii Self-Micro-Emulsifying Drug Delivery Systems (Smedds)

Role of Hydrophilic Surfactants in the Emulsification Mechanistics of Type Iii Self-Micro-Emulsifying Drug Delivery Systems (Smedds)

Formulation and Characterization of Piroxicam as Self-Nano Emulsifying Drug Delivery System

Fabrication and Characterization of Self-microemulsifying Mouth Dissolving Film for Effective Delivery of Piroxicam

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