Fabrication and Characterization of Self-microemulsifying Mouth Dissolving Film for Effective Delivery of Piroxicam

Abstract

Pattewar et al.: Self-microemulsifying Mouth Dissolving Film Self-microemulsifying drug delivery systems are widely used to address water-solubility issues of drug candidates, but with these systems, there is a chance of drug precipitation due to migration of the surfactant in the shell of capsule. Piroxicam is a class II drug that exhibits poor solubility and high permeability. Efforts were made to develop piroxicam self-microemusifying mouth dissolving fi lm using a polymer such as hydroxylpropyl methylcellulose as a fi lm-forming polymer and optimized using response surface methodology of Design-Expert® software version 10. A sublingual self-microemusifying mouth dissolving fi lm was prepared that disintegrated in 26 seconds. The in vitro drug release of self-microemusifying mouth dissolving fi lm was 98.04±0.016% in 5 min. The newly developed sublingual self-microemusifying mouth dissolving fi lm provided rapid absorption of piroxicam (t max ~2 h) and suitable for providing a rapid onset of analgesic action.

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

“…The initial oral SEDDSs can transform the lipid-based drug delivery of hydrophobic drugs via the topical/transdermal route. This statement is supported by successful drug deliveries achieved by SEDDSs developed to improve drug delivery via alternative topical administration routes such as the ocular-, rectal-, vaginal-, and nasal routes of administration [19][20][21][22][23][24][25]. Moreover, SEDDSs remain noteworthy drug delivery vehicles, since approximately 30% of current drugs on the commercial market, together with up to 50% of newly discovered drugs, are of a noteworthy lipophilic nature [17,[48][49][50][51].…”

“…Despite the fact that the literature cannot provide a clear explanation for the mechanism of spontaneous emulsification, the evident success of the self-emulsification drug delivery approach cannot be denied [19][20][21][22][23][24][25]32,33]. Additionally, pseudo-ternary-phase diagrams assist in predicting the behaviours of emulsions established by mysterious spontaneous emulsification [33,100].…”

“…However, numerous solidification techniques have been explored, such as transforming liquid SEDDSs into pellets, dispersible powders, and granules, in order to improve stability of these uniquely simplified systems [2,15,18]. Moreover, apart from rendering enhanced oral drug delivery, SEDDSs have demonstrated the potential for improving drug delivery via diverse pathways, including the ocular-, vaginal-, rectal-, and nasal routes of administration [19][20][21][22][23][24][25]. For example, a recent study was published as the first proof of concept for employing SEDDSs as an oral vaccination vehicle.…”

Development and Evaluation of Self Micro Emulsifying Drug Delivery System (SMEDDS) for Nebivolol Hydrochloride

“…Different approaches have been attempted to increase the aqueous solubility of poorly soluble drugs. The most promising and new techniques to enhance dissolution and improve the bioavailability of poorly water-soluble drugs are Lipid microemulsion formulations, which particularly emphasize self-nano emulsifying(SNEDDS), self-micro emulsifying drug delivery systems (SMEDDS), and self-emulsifying drug delivery systems (SEDDS) [4][5][6] . Self-micro emulsifying oral drug delivery systems are growing popular in the delivery of poorly water-soluble BCS class II drugs 7,8 .…”