Development and cytotoxicity evaluation of a cylindrical pH-responsive chitosan-genipin hydrogel for the oral delivery of diclofenac sodium

Kaufmann, Gabriela; Klein, Manuela Poletto; Goettert, Márcia Inês; Aguirre, Tanira

doi:10.1016/j.eurpolymj.2022.111649

Cited by 9 publications

(2 citation statements)

References 50 publications

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“…Attempting to purify the hydrogels is time-consuming and increases the cost of the hydrogels. Among chemical crosslinking agents, genipin, extract of Gardenia Iasminoides Ellis fruit, has been used to crosslink chitosan because it is a natural crosslinking agent, it is non-toxic, and it has favorable chemical characteristics, thereby obtaining biostable and biocompatible chitosan hydrogels [ 115 , 116 , 117 , 118 ].…”

Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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“…Biyogüvenirliliği ve spesifik çapraz bağlama yeteneği sayesinde günümüzde önemli bir molekül haline gelmiştir [20]. Literatür çalışmalarında genipin özellikle doku mühendisliği alanında kolajen bazlı biyomalzemelerin sentezinde [21,22], pervaporasyon uygulamalarına yönelik membran üretiminde [23], kontrollü ilaç salım sistemlerinde [24,25], biyomedikal malzemelerin üretiminde [26], enzim immobilizasyon uygulamalarında [27,28] çapraz bağlayıcı olarak kullanılmaktadır. Genipinin sitotoksisitesi sıklıkla kullanılan glutaraldehit çapraz bağlayıcının sitotoksisitesinin sadece %0.01 kadardır ve in vivo biyogüvenirliliği literatür çalışmalarında kapsamlı bir şekilde gösterilmiştir [20].…”

Section: Introductionunclassified

Genipin ile çapraz bağlı nanokapsüllerin sentezi ve karakterizasyonu

ÇAĞLAR

Şahbaz

2023

NÖHÜ Müh. Bilim. Derg.

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Yapılan çalışmada doğal bir çapraz bağlayıcı olan genipin kullanılarak sığla esansiyel yağının jelatin ve Arap zamkı ile nanoenkapsülasyonu amaçlanmıştır. Sentez sürecinde kompleks koaservasyon yöntemi kullanılarak ilk olarak sığla yağı jelatin ve Arap zamkı duvar materyalleri ile kaplanmış ve daha sonrasında farklı miktarlarda (150, 250, 350 ve 450 mg) genipin kullanılarak çapraz bağlanması sağlanmıştır. Elde edilen nanokapsüllerin toplam yağ, yüzey yağı ve enkapsülasyon etkinlik değerleri analiz edilmiştir. Genipin miktarının artışı ile nanokapsüllerin yüzey yağ miktarlarında azalış gözlenirken, toplam yağ ve enkapsülasyon etkinlik değerlerinde artış gözlemlenmiştir. %98 enkapsülasyon etkinliğinin sağlandığı nanokapsüllerin yapısal, morfolojik ve termal özelliklerinin incelenmesi için sırasıyla FTIR, FESEM, TGA ve DSC analizleri gerçekleştirilmiştir. Elde edilen sonuçlar sığla yağının jelatin ve Arap zamkı ile nano boyutta başarılı bir şekilde kaplandığı göstermektedir.

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A comprehensive review on genipin: an efficient natural cross-linker for biopolymers

Wahba

2024

Polym. Bull.

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Cross-linkers are pivotal to meliorate the attributes of the biopolymers, which are exploited in the biomedical industries, and also those intended as packaging supplies. Genipin (GN) is an efficacious cross-linker. Moreover, being naturally procured, biodegradable and biocompatible makes it an auspicious candidate for the biomedical and food industries. Accordingly, we attempted to provide a comprehensive review on GN as an efficient cross-linker for biopolymers. Initially, we presented the chief botanical sources of GN. The GN extraction strategies, which adopted safe solvents, were then discussed while highlighting their realized yields. The proposed GN structures, its possible modes of action, and the factors affecting its interactions, such as pH, temperature, and GN concentration were also reviewed. Afterward, the GN applications that mainly involved cross-linking biopolymers and biopolymers containing materials were discussed. These included tissue engineering, wound dressings, drug delivery, and packaging applications. GN capability to activate biopolymers, such as chitosan and gelatin, into covalently reactive enzyme immobilizers was also discussed. Moreover, other important GN applications, such as exploiting it as a colorant for foods and textiles and incorporating it in altered biosensors, were discussed.

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Development and cytotoxicity evaluation of a cylindrical pH-responsive chitosan-genipin hydrogel for the oral delivery of diclofenac sodium

Cited by 9 publications

References 50 publications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Genipin ile çapraz bağlı nanokapsüllerin sentezi ve karakterizasyonu

A comprehensive review on genipin: an efficient natural cross-linker for biopolymers

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