Development and Creation of a Zeta Potential Reference Material of Particles in a Liquid Medium

Abstract

A comprehensive study to develop and create standard samples of the zeta potential unit of particles in a liquid in accordance with the requirements of GOST ISO 13099-2-2016 in the range of measured values from -150 mV to +150 mV was carried out. The existing standard samples of the zeta potential in Russia and the world have been investigated; an analysis of the applicability of the starting materials and components for the creation of new standard samples is given. Samples based on modifi ed polystyrene latex microspheres, bovine serum albumin and supramolecular systems based on aqueous solutions of L-cysteine, N-acetylcysteine, and silver acetate are considered as promising standard samples of the zeta potential of particles. All studies were carried out on equipment from the State Primary Standard of dispersed parameters of aerosols, suspensions and powder materials, GET 163-2020, by electrophoretic light scattering and pH measurement. It was found that polystyrene latex microspheres do not meet the requirements of the task in terms of developing a set of standard samples. Samples based on suspensions of bovine serum albumin do not meet the requirements of GOST ISO 13099-2-2016. Supramolecular systems based on aqueous solutions of L-cysteine, N-acetylcysteine, and silver acetate are proposed as standard samples. Such systems are characterized by the ability to modify the initial potential-determining layer of particles without changing their aggregate stability. Studies of the long-term stability of the developed standard samples of the zeta-potential unit of particles in a liquid have been carried out.

l-Cysteine and N-acetyl-l-cysteine-mediated synthesis of nanosilver-based sols and hydrogels with antibacterial and antibiofilm properties

“…[18][19][20][21] We have shown that L-cysteine (CYS) can simultaneously act as a reducing, capping and gel-forming agent at the simplest mixing of its aqueous solution with silver salts under ambient conditions. [21][22][23][24][25] As a result of the research, we previously found that the surface state and size of the obtained nanoparticles directly determine the ability of the system to form a gel, as well as the properties of the final material: anticancer, catalytic, electrochemical, filmforming.…”

Characterization of particles of the dispersed system based on low-concentrated aqueous solutions of L-cysteine and silver acetate

“…Thus, in systems formed by silver nitrite, a stable value of the zeta potential of plus 35with standard deviation is equal to 3 mV is observed for particles at their size of 50 nm [5]. In turn, when initiating the growth of nanoparticles with silver nitrate or silver acetate salts, a time-stable value of the zeta potential of plus 55 mV with standard deviation is equal to 5 mV and plus 69 mVwith standard deviation is equal to 5 mV, respectively, is observed [2,6,7], but the distribution of particles in the systems is polydisperse.…”

“…As an analytical method for controlling the quality of products in the chemical, biotechnological and food industries, the zeta-potential allows to determine stability in time of suspensions and emulsions [1]. Currently, the laboratory of metrological support for measurements of parameters of aerosols, suspensions and powdery materials of the Russian metrological institute of technical physics and radio engineering(VNIIFTRI) together with scientists of the Tver State University (TvSU) are developing reference materials of the zeta potential of particles of dispersed systems based on supramolecular systems as precursors [2].…”

Physico-Chemical Properties of CdTe/Glutathione Quantum Dots Obtained by Microwave Irradiation for Use in Monoclonal Antibody and Biomarker Testing

“…The novelty and advancements accomplished in this work are the study of the physico-chemical properties of CdTe/GSH-QDs and the use of microwave irradiation in their synthesis. These nanocrystals are used in biology and medicine to achieve cellular and biomarker testing [ 12 , 41 , 42 , 43 , 44 , 45 , 46 ].…”