1999
DOI: 10.1002/(sici)1099-0801(199902)13:1<15::aid-bmc766>3.0.co;2-d
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Development and clinical application of high performance liquid chromatography for the simultaneous determination of plasma levels of theophylline and its metabolites without interference from caffeine

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Cited by 23 publications
(5 citation statements)
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“…The concentration of unchanged theophylline in plasma was measured based on the method reported by Kizu et al 18 with minor modifications. First, 300 μL of acetonitrile, containing 0.3 μg of β‐hydroxyethyltheophylline as an internal standard (IS), was added to 100 μL of a plasma sample.…”
Section: Methodsmentioning
confidence: 99%
“…The concentration of unchanged theophylline in plasma was measured based on the method reported by Kizu et al 18 with minor modifications. First, 300 μL of acetonitrile, containing 0.3 μg of β‐hydroxyethyltheophylline as an internal standard (IS), was added to 100 μL of a plasma sample.…”
Section: Methodsmentioning
confidence: 99%
“…Among the reported methods for the determination of theophylline in plasma, such as fluorescent polarized immunoassay (Rojanasthien et al, 2001), chemiluminescent immunoassay (Malliaros et al, 1997), HPLC (Schrieber-Deturmeny and Bruguerolle, 1996;Umemura et al, 1998;Kizu et al, 1999), LC-MS (Watson et al, 2001;Kanazawa et al, 2000), HPLC is the most common used one. In this study, an HPLC method was used to determine the pharmacokinetics of TGS SR tablets with the new asymmetric regimen, which was previously developed and validated in our group and used to study the single-and multiple-dose pharmacokinetics of TSG SR tablets (Yao et al, 2000).…”
Section: Methods Development and Validationmentioning
confidence: 99%
“…Several high-performance liquid chromatography (HPLC)-based bioanalytical methods have been published for the quantitation of theophylline [3][4][5]. Most of these published methods suffer from long HPLC run times (over 60 min) and high detection limits (greater than 300 ng/mL for theophylline metabolites).…”
Section: Introductionmentioning
confidence: 99%