2003
DOI: 10.1002/bmc.214
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Pharmacokinetics of a new sustained‐release formulation of theophylline sodium glycerinate in healthy subjects with a new asymmetric dosage regimen

Abstract: Pharmacokinetics of a new sustained-release formulation of theophylline sodium glycerinate in healthy subjects was studied. In this study, a new asymmetric dosage regimen was presented to achieve a better accordance with the chronotherapy of asthma. Each of 10 subjects was administered one tablet (equivalent to 0.1 g anhydrous theophylline) in the morning and four tablets in the evening for a consecutive 6 days and blood samples were collected at the predetermined time and analyzed by a validated HPLC method. … Show more

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