Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug

Sharma, Harshita; Kumar, Krishan; Choudhary, Chetan; Mishra, Pawan Kumar; Vaidya, Bhuvaneshwar

doi:10.3109/21691401.2014.978980

Cited by 99 publications

(58 citation statements)

References 35 publications

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“…Drug content of the CNFs was calculated by an indirect method, 13 whereby the supernatant collected was analyzed for the amount of drug present in it, and finally the drug loading was calculated using the following formula:…”

Section: Determination Of Drug Loading and Drug Entrapment Efficiencymentioning

confidence: 99%

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

156

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Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%±1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%±2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%±2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

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Section: Determination Of Drug Loading and Drug Entrapment Efficiencymentioning

confidence: 99%

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

156

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“…Nanotechnology can be specified as a pharmaceutical system whose various nanoscale materials have been utilized for different intention, such as biosensors, bio-imaging, diagnostic and drug delivery specially for cancer therapy (Akbarzadeh et al 2012, Sharma et al 2016. A drug delivery system must be biocompatible, biodegradable, and efficiently durable.…”

Section: Cytotoxic Studiesmentioning

confidence: 99%

GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line

Torbati

Ebrahimian

Yousefi

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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The graphene oxide nanosheets can act as a nanocarrier for the delivery of therapeutic agents. The PEGylated GO has high solubility, good stability, and more biocompatibility in physiological solutions. In this study, the anticancer effects of synthesized GO-PEG as a drug nanocarrier evaluated to estimate the synergistic cytotoxic effect of drugs loaded on this type of nanocarrier and to determine the actual effect of any drugs encapsulated on it. The cytotoxic effects of GO-PEG nanosheets were evaluated on HeLa cell line by MTT assay. The results exhibited cytotoxic property of PEGylated GO drug nanocarrier significantly is dose dependent and incubation time dependent.

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“…The resistant of cancer while there is treatment for long time, will cause progressive type of malignant tumors, requires the development of novel therapeutic modalities to overcome chemo-resistance and enhance prolong surviving effect [15]. Nanoparticles is a promising treatment modality to produce non-toxic and efficient cancer therapy [6,26]. Nanoparticles carry unique chemical and physical features [31], these features utilized in biomedical applications [20] such as cancer [9].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles Targeting Human Cervical Cancer Cells

Merkadh¹,

Hameed²

2019

SIJOG

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The most disturbing gynecologic malignancies are cervical cancer particularly in the developing world with the same high incidence in Iraqi women. Cervical carcinoma has a high rate of mortality. The high death rate is associated with presence of human papillomavirus (HPV) infection. Cervical carcinoma is hard to treat, and conventional therapies are very aggressive which lead for the need for new approaches of therapy. Nanoparticles is a promising treatment modality to produce non-toxic and efficient cancer therapy. Gold nanoparticles (AuNPs) accumulate in cancer cells selectively. The current work was aimed to study cytotoxicity and cell death induced by AuNPs on cervical carcinoma cells. Methods: Cytotoxicity of AuNPs was assessed by MTT viability assay and analysed using multiple comparison ANOVA tests. Results: AuNPs nanoparticles from 12.5 up to 50 µg/mL for 72 hours showed concentration-dependent killing activity. Conclusion: Gold nanoparticles have anti-cervical carcinoma cells activity by cell death induction.

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Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug

Cited by 99 publications

References 35 publications

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line

Gold Nanoparticles Targeting Human Cervical Cancer Cells

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